DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and PLCD3

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_024306322.1	Gene:	PLCD3 / 113026	HGNCID:	9061	Length:	834	Species:	Homo sapiens

Alignment Length:	849	Identity:	248/849 - (29%)
Similarity:	389/849 - (45%)	Gaps:	161/849 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWK---SEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKN 92
            ::.:...:.::.|:::.|.|..::::   .......:..:..:..:|.|...      :.:.:..
Human    72 RKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQS------EGLRRFG 130

  Fly    93 GTNIPELDKRSLTIC-----SNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMC 152
            |...|   .|.|||.     .|.|        :..|.|..|:.|:.|:.|:...:.|      |.
Human   131 GAFAP---ARCLTIAFKGRRKNLD--------LAAPTAEEAQRWVRGLTKLRARLDA------MS 178

  Fly   153 LRK---HWMRLSYC----VEKSGKI---PVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTK 207
            .|:   ||:. ||.    ..:..|:   .:|:|.:.......:...|...|:.    |.:.....
Human   179 QRERLDHWIH-SYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKEC----DHSNNDRL 238

  Fly   208 EQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEE- 271
            |....::|   ..::..|.::||:|...: |:...:|..:.::|:.|:.             ||
Human   239 EGAEIEEF---LRRLLKRPELEEIFHQYS-GEDRVLSAPELLEFLEDQG-------------EEG 286

  Fly   272 ---KRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSS 333
               .|..::|..|||:|..|::..|:||||..||:|.|.|.:.......:.:|:||||||:|:||
Human   287 ATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSS 351

  Fly   334 HNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAI 398
            |||||:..||||.||.|.|.:....||||||||||.|.|  .||::.|||...::|||:|.:||:
Human   352 HNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPG--GEPVIYHGHTLTSKILFRDVVQAV 414

  Fly   399 ADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRK 463
            .|.||..|.||||||.||||...||..:|::.....||:|:.:.| |.| :|. .||.|.:||.:
Human   415 RDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQAL-DSP-NPE-ELPSPEQLKGR 476

  Fly   464 ILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGG 528
            :|:|.|:: |.....:.......|.:.:||.||:.......:...|...:||.:|.|.
Human   477 VLVKGKKL-PAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAV------- 533

  Fly   529 GAEAEAAAANYSGST--TNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMS------------- 578
                      |..:|  ..:||    ..|..||.:.....:...|.:.....
Human   534 ----------YCHATRLRTLHP----APNAPQPCQVSSLSERKAKKLIREAGQKRVRSGGRVTWG 584

  Fly   579 ------------------------SFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNY 619
                                    |...||..|       .||.:|.||::|:||.|.|.:|:||
Human   585 RAWALFPGGYRPGLWVRDPRSLSRSHPNSAPGN-------SFVRHNARQLTRVYPLGLRMNSANY 642

  Fly   620 MPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVI 684
            .||..||:|||:|:||||:....|.||.|:|..||.|||:|||..:|:.|..|||....|....:
Human   643 SPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTL 707

  Fly   685 AAQCSVKVIAGQFL----SDKK---VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED-P 741
                |::|:..|.|    ::|.   |...|.:::.|:|:|..::|  |..|.|||.||.:.:. .
Human   708 ----SIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQE--TDYVLNNGFNPRWGQTLQ 766

  Fly   742 FVFRKVVLPDLAVLRFGV--YEES--GKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVN 802
            |..|   .|:||::||.|  |:.:  ...:||..|||..|:.||||:.|.::....:|...||:.
Human   767 FQLR---APELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQ 828

  Fly   803 IELK 806
            |.::
Human   829 IRIQ 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	20/125 (16%)
		PLN02952	224..786	CDD:178538	209/616 (34%)
		EF-hand_like	227..318	CDD:286375	26/94 (28%)
		PI-PLCc_beta	318..653	CDD:176533	131/373 (35%)
		C2_PLC_like	689..806	CDD:175974	42/128 (33%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
PLCD3	XP_024306322.1	PH_PLC_delta	65..181	CDD:270169	21/131 (16%)
		EFh_PI-PLCdelta3	186..324	CDD:320048	36/159 (23%)
		EF-hand motif	186..215	CDD:320048	6/29 (21%)
		EF-hand motif	222..251	CDD:320048	5/35 (14%)
		EF-hand motif	255..287	CDD:320048	9/45 (20%)
		EF-hand motif	291..324	CDD:320048	15/32 (47%)
		PI-PLCc_delta3	336..676	CDD:176567	131/373 (35%)
		C2_PLC_like	705..832	CDD:175974	42/135 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820