DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and plcb2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_017952419.2	Gene:	plcb2 / 101734935	XenbaseID:	XB-GENE-6045997	Length:	1250	Species:	Xenopus tropicalis

Alignment Length:	1178	Identity:	413/1178 - (35%)
Similarity:	613/1178 - (52%)	Gaps:	159/1178 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IIPVPPE------LTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELC 68
            |.|:.|.      |:.|..|.:|.:      |.......:.:||..|::|||..:.::.:.:||.
Frog     4 ITPILPPVEVKSYLSKGERFIKWDD------ETSLASPVILRVDPKGYYLYWTFQSKEMEFVELT 62

  Fly    69 QVSDIRAGGTPKDPKILDKVTKKNGTNIPELD--KRSLTICSNTDYINITYHHVICPDAATAKIW 131
            .:.|.|.|...|.|| ..|:.:....:.||.:  .::|||.:..|.:::|:|:.:.......|.|
Frog    63 SIRDTRFGKFAKAPK-SQKLREVFNLDFPENNFLAKALTIVTGPDMVDLTFHNFVSYKENVGKAW 126

  Fly   132 LDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAG 196
            ...|..:..|....|.|......|..::|...:...|||||:...:.|.:.:  |.|...:....
Frog   127 AADILSVVTNPLVPNACRYSFFEKIHVKLQLQLNSEGKIPVRNFFQMFPADR--KRVEQALNSCH 189

  Fly   197 LPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRM 261
            |...||..:..|.|....|.....::|||.:|:|:|||.....:.:::.....:|:|.||||.|:
Frog   190 LSKGKNDAINPEDFPESVFRTFLMQLCPRPEIDEIFTSYHSKAKPYMTKVHLTKFINQKQRDSRL 254

  Fly   262 NEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLA 326
            ||:::|..:.::...:|..||......:..|:|.:|...:|...||:...||::..|.:|.|||:
Frog   255 NELIFPPAKTEQVQGLIEKYEPSVINVQRGQLSPEGMVWFLCGSENSITSLDKIPIYQDMSQPLS 319

  Fly   327 HYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILF 391
            ||:|||||||||:..|..|.||.||||||||:||||||||||.||..:||||:|||....|||||
Frog   320 HYFINSSHNTYLTAGQFSGVSSPEMYRQTLLSGCRCVELDCWKGKPPEEEPIITHGFTMTTEILF 384

  Fly   392 KDCIQAIADCAFVSSEYPVILSFENHCNR-AQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLP 455
            ||.|:|||:.||.:|.||||||||||.:. .||.|:|:||...|||:||.:.|..:||.||..||
Frog   385 KDVIEAIAESAFKTSPYPVILSFENHVDSPKQQAKMAEYCRTIFGDMLLTDALEKYPLKPGNLLP 449

  Fly   456 PPCKLKRKILIKNKRMKP---------EVEKVELELWLKGELKTD---DDPEEDASAGKPPEAAA 508
            .|.:|..|||||||:.:.         ..:....|  ....|.:|   :.|||    ||..|...
Frog   450 SPQELLGKILIKNKKNQSFANQDKKANSCDSTSSE--QTSSLSSDNSGEGPEE----GKEAENEE 508

  Fly   509 APAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNI 573
            ....|.|.......:.||....||.|            :..:||:|||.|||||..|:.:.:||.
Frog   509 MTENADEEEMKQMQSDEGTASQEATA------------YEEMSSLVNYIQPIKFDSFEVSAQKNQ 561

  Fly   574 AHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQS 638
            ::.:|||.|:.....|.:..:.||.|||||||||||||||.||||||||:|||||||||:||||:
Frog   562 SYVVSSFVETKAYELLTKFPVQFVEYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQT 626

  Fly   639 SDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKV 703
            .|:|||.|...|::||..|||||.:||||.||.||||....:|.|:|...|:.:::||||.:|.|
Frog   627 MDIPMQQNMALFQFNGCSGYLLKHEFMRRGDKQFDPFTVDRIDVVVANTVSITILSGQFLCEKCV 691

  Fly   704 GTYVEVDMFGLPSDTVKKEFRTRLVA-NNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKIL 767
            .|||||::||||.|. |::::|::.: .|.:|||:.|:||||.|:::|:||.||..|:||.||.:
Frog   692 KTYVEVELFGLPGDP-KRKYKTKVTSVPNTINPVWKEEPFVFEKILMPELASLRVAVFEEGGKFI 755

  Fly   768 GQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQ 832
            |.||:|:|.:::||.|:.||:|:|.|:::|.|||.:|:..||||.:.|....||:|...:.|.:.
Frog   756 GHRIIPIDLIRSGYHHICLRSESNMPLTMPSLFVYVEVTDYVPDVWADLSQALSNPIKHSKANEC 820

  Fly   833 QNEQMKAL------------GIEEQSG------GAARDAGKAKEEEKKEPPLVFEPVTLESLRQE 879
            ::.::|..            ||..|:|      ...:||.|    |..||....|    |.|:::
Frog   821 KSMKVKTAPSGEISSASKPNGIPGQNGPKGLPTSGVQDAAK----EITEPQTANE----EELQKQ 877

  Fly   880 KGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLI-----------KGKSKDDIRNDANI 933
            |||.|:.|||.|||..|.::..|.|..:.:...:|..:|.           ||:.|..|.:|
Frog   878 KGFLKLQKKQEKELKELERRTLKRREEIVQKYTSAFSELYTQANKRKNSLPKGQKKKSIPDD--- 939

  Fly   934 KNSINDQTKQW----------TDMIARHRKEEWDM-----------LRQHVQDSQDAMKALMLTV 977
                 |....|          ..::...||.|.::           |::..|.|.:.:..|:...
Frog   940 -----DYGSVWGAGEIPGKGDPQVLEMKRKMEEELTCLGEEQYETILKKKEQHSNEQISKLIELA 999

  Fly   978 QAAQIKQLEDRHARDIKDLNAKQAK-------------MSADTAKEVQNDKTLKTKN-------- 1021
            |..|:.:|  :..::..|.:.||.|             ||.:|.::...::..|..|
Frog  1000 QERQVAEL--KILKEAADSDTKQMKKKLEIKRLERLECMSKNTMEKASQERLKKEINNSHIQEVV 1062

  Fly  1022 -----------EKDRRLREKRQNNVKRFMEEKKQIGVK-QGRAMEKLK--------LAHSKQIEE 1066
                       :..::|.||:...::|..|.:.|:..: |...:|||.        |.::..:..
Frog  1063 QVLQLVSDKWAKNQQKLEEKQAEGLQRIKEREDQVQKELQEEYIEKLNSLAAEVRDLVYNTMVTW 1127

  Fly  1067 FSTDVQKL 1074
            |.|:.:.|
Frog  1128 FPTEAKSL 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	33/133 (25%)
		PLN02952	224..786	CDD:178538	271/575 (47%)
		EF-hand_like	227..318	CDD:286375	26/90 (29%)
		PI-PLCc_beta	318..653	CDD:176533	176/347 (51%)
		C2_PLC_like	689..806	CDD:175974	57/117 (49%)
		DUF1154	866..908	CDD:284131	16/41 (39%)
		Mer2	<887..1003	CDD:286200	32/160 (20%)
plcb2	XP_017952419.2	PH_14	12..141	CDD:407659	32/135 (24%)
		EFh_PI-PLCbeta2	149..299	CDD:320039	41/151 (27%)
		PI-PLCc_beta2	311..641	CDD:176561	176/347 (51%)
		C2_PLC_like	675..794	CDD:175974	57/119 (48%)
		DUF1154	872..908	CDD:399553	15/35 (43%)
		PLC-beta_C	956..1131	CDD:400858	31/176 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010