DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and LOC100537538

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_021322946.1	Gene:	LOC100537538 / 100537538	-ID:	-	Length:	1213	Species:	Danio rerio

Alignment Length:	1175	Identity:	583/1175 - (49%)
Similarity:	778/1175 - (66%)	Gaps:	92/1175 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI 65
            |.|.|||:|..|||..:..|..|||:.|:...     ||.:..|||||.||||.|||||::|.|:
Zfish    27 MAKPYEFNWQRPVPQFMQKGACFDRFDEDPLV-----FESNCFFKVDESGFFLTWKSEGKEGQVL 86

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKI 130
            |...::.||.....||||:|..: :.:|.....|:.|.:.|||.||.:|:::.:::..:..|||.
Zfish    87 EFSLINSIRDASALKDPKVLCAL-EASGKCESNLEDRIICICSGTDLVNLSFMYMVTQNPTTAKE 150

  Fly   131 WLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDA 195
            |.||:|.:..|.:|||:|||.||||||||||:....:|:|||:::.:|||||||||.::..:||.
Zfish   151 WTDGLRSLIQNTRANNVCPMTCLRKHWMRLSFLTNVNGQIPVRSITRTFASGKTEKGIFQALKDL 215

  Fly   196 GLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPR 260
            |||..||..:.:|.|||||||:|..|:|||.|||.||......|.|::|:|||:.|:||.|||||
Zfish   216 GLPSGKNDEIQREIFTFDKFYSLTQKICPRTDIEVLFKKFKGDKGDYLSVEQFVHFLNDNQRDPR 280

  Fly   261 MNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPL 325
            :||||:|.:..|...:||..||.||:.|:...:|.|||.|:||||||||||||||:.|.|||.||
Zfish   281 LNEILFPFFNSKCAFQIIQRYEPDEKLKRKGLLSCDGFCRFLMSDENAPVFLDRLEVYQEMDHPL 345

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            :||:|||||||||:|||.|||||||:|||.||.||||||||||:|||||:|||:|||.|.||::|
Zfish   346 SHYFINSSHNTYLTGRQFGGKSSVEIYRQVLLTGCRCVELDCWDGKGEDQEPIITHGKAMCTDVL 410

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLP 455
            |||.||.|.:.||::|||||||||||||.:.||||||:||:|.|||||||:||.|.|::||.|||
Zfish   411 FKDVIQGIKETAFLTSEYPVILSFENHCTKHQQYKLARYCEDIFGDLLLKQPLEDFPMEPGCPLP 475

  Fly   456 PPCKLKRKILIKNKRMKPEVEKVELELWLK----GE------LKTDDDPEEDASAGKPPEA---- 506
            .|..||.||||||:|:||||||.:||.:.|    ||      |..|::.:|..:|....||
Zfish   476 SPNDLKGKILIKNRRLKPEVEKKQLEDFRKHMEAGEPSVSTNLFEDENEDETNTAELLNEAHPER 540

  Fly   507 -----AAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYS--GSTTNVHPWLSSMVNYAQPIKFQG 564
                 ........|........||....|:..|...:|:  .:|||:||:||:::||||.:||.|
Zfish   541 IHGCLITEEENREEEVLLRHRKAEEENVADELAVIQSYTYVAATTNIHPYLSNIINYAQAVKFTG 605

  Fly   565 FDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGC 629
            ||:|.||||.||||||.||.|:.||:.::|:||||||||||||||||.|.||||||||:||||||
Zfish   606 FDEAEEKNIHHNMSSFNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGC 670

  Fly   630 QMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIA 694
            ||||||||:.||.||||||||||||.||:|||||||||.|:.||||::.||||||||.|||:||:
Zfish   671 QMVSLNFQTPDLAMQLNQGKFEYNGSCGFLLKPDFMRRPDRMFDPFSETPVDGVIAATCSVQVIS 735

  Fly   695 GQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGV 759
            ||||||||:||||||||:|||:||::||||||:|.|||||||||.:.||||||:||||||||..|
Zfish   736 GQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNAEAFVFRKVILPDLAVLRVAV 800

  Fly   760 YEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPR 824
            |:::.|::|||||||||||:||||:|||.|.|.|:.|..:|.||.||.||||||...:..||||:
Zfish   801 YDDNNKLIGQRILPLDGLQSGYRHISLRNEYNKPLPLATVFCNIILKTYVPDGFGAIVDALSDPK 865

  Fly   825 GFAGAAKQQNEQMKALGIE--------------------EQSG---GAARDAGKAKEE---EKKE 863
            .|....:::.:||:|:|||                    .|:|   ...:|:.:.:|.   ..||
Zfish   866 KFLSICEKRTDQMRAMGIEASDIADVPSDVWKGNKKRKTNQAGMMMKPQKDSDRPRENMPISSKE 930

  Fly   864 PPLVFEP-VTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKD-- 925
            ...|..| :|::.|:|.|.|.|:.|||.||::.|:|||||...:::.:.:|.:|:.:....|:
Zfish   931 DSSVLTPQLTIDDLKQTKTFLKLIKKQQKEVNALKKKHAKAHAALRSSHSAQLDRTVAQHEKEKH 995

  Fly   926 ------------------------DIRND-----ANIKNSIND----QTKQWTDMIARHRKEEWD 957
                                    ||...     .|.|:.:.|    |..:.::|:..|..||..
Zfish   996 TLEKQLHKNTSRKVSESSSLEMSRDIEQQMKTAVMNHKSKVKDMASAQASECSEMLRWHSAEEQT 1060

  Fly   958 MLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNE 1022
            ::.||:....:.:..|::..|..|..||...|.|..|::...|||.|.:::|.:..||::|.|.|
Zfish  1061 VVEQHLLQQCEQLHKLLMLEQEQQTHQLTLLHERQSKEMRTNQAKTSMESSKAISQDKSIKNKAE 1125

  Fly  1023 KDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEEAYKT 1087
            ::||:||....|.::|:.|:|::.:||.:..|:|:.|..:|:|......::|.:....:.:.
Zfish  1126 RERRVRELNSTNTRKFLTERKRLAMKQTKECEQLQAAQREQLERLEKHNEELSNSCYAKSQC--- 1187

  Fly  1088 QGKTE 1092
            ||:.|
Zfish  1188 QGQNE 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	51/131 (39%)
		PLN02952	224..786	CDD:178538	373/582 (64%)
		EF-hand_like	227..318	CDD:286375	51/90 (57%)
		PI-PLCc_beta	318..653	CDD:176533	219/355 (62%)
		C2_PLC_like	689..806	CDD:175974	83/116 (72%)
		DUF1154	866..908	CDD:284131	19/42 (45%)
		Mer2	<887..1003	CDD:286200	36/150 (24%)
LOC100537538	XP_021322946.1	PH_PLC_beta	43..169	CDD:270167	51/131 (39%)
		EFh_PI-PLC	174..326	CDD:333715	81/151 (54%)
		EF-hand motif	174..203	CDD:320029	16/28 (57%)
		EF-hand motif	209..237	CDD:320029	14/27 (52%)
		EF-hand motif	247..276	CDD:320029	14/28 (50%)
		EF-hand motif	293..326	CDD:320029	15/32 (47%)
		PI-PLCc_beta	338..694	CDD:176533	219/355 (62%)
		C2_PLC_like	728..844	CDD:175974	82/115 (71%)
		DUF1154	937..>962	CDD:310911	12/24 (50%)
		PLC-beta_C	1063..1184	CDD:312287	36/120 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595549
Domainoid	1	1.000	242	1.000	Domainoid score	I2194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8471
Inparanoid	1	1.050	1065	1.000	Inparanoid score	I242
OMA	1	1.010	-	-		QHG45247
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		otm26212
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	1	1.100	-	-	LDO	PTHR10336
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910