Protein Alignment norpA and plcb4a

DIOPT Version :10

• Sequence 1: NP_525069.2
• Gene: norpA / 31376
• FlyBaseID: FBgn0262738
• Length: 1095
• Species: Drosophila melanogaster
• Sequence 2: XP_021322946.2
• Gene: plcb4a / 100537538
• ZFINID: ZDB-GENE-231129-2
• Length: 1213
• Species: Danio rerio
• Alignment Length: 1175
• Identity: 580/1175 - (49%)
• Similarity: 772/1175 - (65%)
• Gaps: 92/1175 - (7%)

  Fly     1 MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI 65
            |.|.|||:|..|||..:..|..|||:.|:...     ||.:..|||||.||||.|||||::|.|:
Zfish    27 MAKPYEFNWQRPVPQFMQKGACFDRFDEDPLV-----FESNCFFKVDESGFFLTWKSEGKEGQVL 86

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKS 130
            |...::.||.....||||:|..: :.:|.....|:.|.:.|||.||.:|:::.:::..:..|||.
Zfish    87 EFSLINSIRDASALKDPKVLCAL-EASGKCESNLEDRIICICSGTDLVNLSFMYMVTQNPTTAKE 150

  Fly   131 WQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDA 195
            |...||.:..|.||.||||...|.|||||||:....:.:|||:::.:|||||||||.::..:||.
Zfish   151 WTDGLRSLIQNTRANNVCPMTCLRKHWMRLSFLTNVNEQIPVRSITRTFASGKTEKGIFQALKDL 215

  Fly   196 GLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPR 260
            |||..||..:.:|.|||||||:|..|:|||.|||.||......|.|::|:|||:.|:||.|||||
Zfish   216 GLPSGKNDEIQREIFTFDKFYSLTQKICPRTDIEVLFKKFKGDKGDYLSVEQFVHFLNDNQRDPR 280

  Fly   261 MNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPL 325
            :||||:|.:..|...:||..||.||:.|:...:|.|||.|:||||||||||||||:.|.|||.||
Zfish   281 LNEILFPFFNSKCAFQIIQRYEPDEKLKRKGLLSCDGFCRFLMSDENAPVFLDRLEVYQEMDHPL 345

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            :||:|||||||||:|||.|||||||:|||.||.||||||||||:|||||:|||:|||.|.||::|
Zfish   346 SHYFINSSHNTYLTGRQFGGKSSVEIYRQVLLTGCRCVELDCWDGKGEDQEPIITHGKAMCTDVL 410

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLP 455
            |||.||.|.:.||::|||||||||||||.:.||||||:||:|.|||||||:||.|.|::||.|||
Zfish   411 FKDVIQGIKETAFLTSEYPVILSFENHCTKHQQYKLARYCEDIFGDLLLKQPLEDFPMEPGCPLP 475

  Fly   456 PPCKLKRKILIKNKRMKPEVEKVELELWLK----GE------LKTDDDPEEDASAGKPPEA---- 506
            .|..||.||||||:|:||||||.:||.:.|    ||      |..|::.:|..:|....||
Zfish   476 SPNDLKGKILIKNRRLKPEVEKKQLEDFRKHMEAGEPSVSTNLFEDENEDETNTAELLNEAHPER 540

  Fly   507 -----AAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYS--GSTTNVHPWLSSMVNYAQPIKFQG 564
                 ........|........||....|:..|...:|:  .:|||:||:||:::||||.:||.|
Zfish   541 IHGCLITEEENREEEVLLRHRKAEEENVADELAVIQSYTYVAATTNIHPYLSNIINYAQAVKFTG 605

  Fly   565 FDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGC 629
            ||:|.||||.||||||.||.|:.||:.::|:||||||||||||||||.|.||||||||:||||||
Zfish   606 FDEAEEKNIHHNMSSFNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGC 670

  Fly   630 QMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIA 694
            ||||||||:.||.||||||||||||.||:|||||||||.|:.||||::.||||||||.|||:||:
Zfish   671 QMVSLNFQTPDLAMQLNQGKFEYNGSCGFLLKPDFMRRPDRMFDPFSETPVDGVIAATCSVQVIS 735

  Fly   695 GQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGV 759
            ||||||||:||||||||:|||:||::||||||:|.|||||||||.:.||||||:||||||||..|
Zfish   736 GQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNAEAFVFRKVILPDLAVLRVAV 800

  Fly   760 YEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPR 824
            |:::.|::|||||||||||:||||:|||.|.|.|:.|..:|.||.||.||||||...:..||||:
Zfish   801 YDDNNKLIGQRILPLDGLQSGYRHISLRNEYNKPLPLATVFCNIILKTYVPDGFGAIVDALSDPK 865

  Fly   825 GFAGAAKQQNEQMKALGIE--------------------EQSG---GAARDAGKAKEE---EKKE 863
            .|....:::.:||:|:|||                    .|:|   ...:|:.:.:|.   ..||
Zfish   866 KFLSICEKRTDQMRAMGIETSDIADVPSDVWKGNKKRKTNQAGMMMKPQKDSDRPRENMPISSKE 930

  Fly   864 PPLVFEP-VTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKD-- 925
            ...|..| :|::.|:|.|.|.|:.|||.||::.|:|||||.:.:::.:.:|.:||.:....|:
Zfish   931 DSSVLTPQLTIDDLKQTKTFLKLIKKQQKEVNALKKKHAKAQHALRSSHSAQLDKTVAQHEKEKH 995

  Fly   926 ------------------------DIRND-----ANIKNSIND----QTKQWTDMIARHRKEEWD 957
                                    ||...     .|.|:.:.|    |..:.::|:..|..||..
Zfish   996 TLEKQLHKNTSRKVSESSSLEMSRDIEQQMKTAVMNHKSKVKDMASAQASECSEMLRWHSAEEQT 1060

  Fly   958 MLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNE 1022
            ::.||:....:.:..|::..|..|..||...|.|..|::...|||.|.:::|.:..||::|.|.|
Zfish  1061 VVEQHLLQQCEQLHKLLMLEQEQQTHQLTLLHERQSKEMRTNQAKTSMESSKAISQDKSIKNKAE 1125

  Fly  1023 KDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEEAYKT 1087
            ::||:||....|.::|:.|:|::.:||.:..|:|:.|..:|:|......::|.:....:.:.
Zfish  1126 RERRVRELNSTNTRKFLTERKRLAMKQTKECEQLQAAQREQLERLEKHNEELSNSCYAKSQC--- 1187

  Fly  1088 QGKTE 1092
            ||:.|
Zfish  1188 QGQNE 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_525069.2	PH_PLC_beta	17..149	CDD:270167	51/131 (39%)
		EFh_NorpA_like	154..306	CDD:320042	79/151 (52%)
		EF-hand motif	154..183	CDD:320042	14/28 (50%)
		EF-hand motif	189..218	CDD:320042	15/28 (54%)
		EF-hand motif	227..256	CDD:320042	14/28 (50%)
		EF-hand motif	273..306	CDD:320042	15/32 (47%)
		PI-PLCc_beta	318..653	CDD:176533	219/355 (62%)
		C2_PLC_like	689..806	CDD:175974	83/116 (72%)
		DUF1154	865..909	CDD:461969	19/44 (43%)
		PLC-beta_C	952..1073	CDD:462571	37/120 (31%)
plcb4a	XP_021322946.2	None