DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and plcd3

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_002935564.3	Gene:	plcd3 / 100497993	XenbaseID:	XB-GENE-966578	Length:	747	Species:	Xenopus tropicalis

Alignment Length:	800	Identity:	254/800 - (31%)
Similarity:	383/800 - (47%)	Gaps:	162/800 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LFKVDEYGFFLYWKSE---GRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSL 104
            |::::..|..::::|:   .|...:..:..:..:|.|...:.       .:|.|...||
Frog    72 LYRLESDGMTVWYESQAKKARSKQIFSVLHIESVREGHQSEG-------LQKYGRRFPE------ 123

  Fly   105 TIC---------SNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRK---HW 157
            |.|         .|.|        :.......|..|:.|::|:....:|      |..|:   ||
Frog   124 TCCFTIAFKGRRKNLD--------LAASSEKEALNWVQGLQKLMKRAEA------MSQREKLVHW 174

  Fly   158 MRLSYC-------VEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKF 215
            : ..|.       .||.....||.:.|.......:...|...|..    |::.|.|.|....::|
Frog   175 I-WDYLRQADRDGDEKMTFQEVKDMLKMINIDLNDIYAYNLFKAC----DRSNTNTLEDHEIEEF 234

  Fly   216 YALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIIND 280
            ..   |:..|.::||:|...: |:...:|.|:..:|:..:..|..:          :|..|:|..
Frog   235 CT---KLMHRPEVEEIFHHYS-GEDRVLSAEELQEFLQAQGEDATL----------ERAKELIQK 285

  Fly   281 YELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDF-YMEMDQPLAHYYINSSHNTYLSGRQIG 344
            |||:|..|::..|.::||..||:||: ..:|..:... |.:|.|||.||:|:|||||||:..|:.
Frog   286 YELNETAKQHDLMMMEGFMMYLLSDD-GDIFNQKHRMAYQDMTQPLCHYFISSSHNTYLTNHQLV 349

  Fly   345 GKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYP 409
            |:||.|.|.:..:.||||||||||  :|...||::.|||...::|||||.:..|.|.||.:|.||
Frog   350 GESSTESYIRVFMEGCRCVELDCW--EGPSGEPVIYHGHTLTSKILFKDVVTTIRDYAFKNSPYP 412

  Fly   410 VILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRM--K 472
            ||||.||||...||.|:|.:..:..||:|:.:|||....   ..||.|..||.|.|:|.|::  :
Frog   413 VILSLENHCGLEQQVKMANHLREILGDMLVTKPLPGADT---ARLPSPEALKGKFLLKGKKLNNR 474

  Fly   473 PEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAA 537
            ..||:.|                     |||               ..:.|.|
Frog   475 KSVEEEE---------------------GKP---------------RMDTAKE------------ 491

  Fly   538 NYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKR 602
                        ||.:|.|.|.::::|     :......||||:|......:|.|.|:.|.||.|
Frog   492 ------------LSDLVVYCQTVEYRG-----QPGNVCEMSSFSEDKVRRLIKDSGINLVRYNAR 539

  Fly   603 QMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRR 667
            |:|||||.|.||:||||.||..||||||:|:||||:....|.||:|:|:.||.|||:|||:|:|:
Frog   540 QLSRIYPDGLRANSSNYCPQEMWNAGCQLVALNFQTPGYTMDLNRGRFQDNGLCGYVLKPEFLRK 604

  Fly   668 ADKDFDPFADAPVDGVIAAQCSVKVIAGQFL-------SDKKVGTYVEVDMFGLPSDTVKKEFRT 725
            .|..|:|.:.:....::    .||||:.|.|       .:..|..:|.|::.|:..   |||..|
Frog   605 EDSYFNPDSPSKEPKLL----FVKVISAQQLPKLNKEKPNSIVDPFVRVEIHGVGK---KKEKET 662

  Fly   726 RLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGV--YEE--SGKILGQRILPLDGLQAGYRHVSL 786
            :.:.|||.||.:||  .:..:|.:|:||::||.|  |::  |...:||..||...|:.|||||.|
Frog   663 KYILNNGFNPYWNE--ILQLEVQVPELALVRFVVEDYDKTSSNDFVGQYTLPFLSLKQGYRHVHL 725

  Fly   787 RTEANFPMSLPMLFVNIELK 806
            .::....:|...|||.|.::
Frog   726 LSKDGASLSPATLFVQIRIE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	19/117 (16%)
		PLN02952	224..786	CDD:178538	211/575 (37%)
		EF-hand_like	227..318	CDD:286375	24/91 (26%)
		PI-PLCc_beta	318..653	CDD:176533	133/336 (40%)
		C2_PLC_like	689..806	CDD:175974	46/127 (36%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plcd3	XP_002935564.3	PH_PLC_delta	54..169	CDD:270169	20/123 (16%)
		EFh_PI-PLCdelta3	174..311	CDD:320048	38/155 (25%)
		PI-PLCc_GDPD_SF	323..590	CDD:417475	133/336 (40%)
		C2_PLC_like	618..745	CDD:175974	46/135 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010