DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and LOC100496658

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_017950677.1	Gene:	LOC100496658 / 100496658	-ID:	-	Length:	1301	Species:	Xenopus tropicalis

Alignment Length:	1371	Identity:	308/1371 - (22%)
Similarity:	458/1371 - (33%)	Gaps:	551/1371 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKD 81
            |.||.|...:::.:.:..|   .|....::|......:..:|..:|| |::.::.:||.|...:|
Frog    30 LETGTVLTLFYQKKSQRPE---RRTFQLRMDTRQVVWFRTTEKVEGD-IDVREIKEIRPGKNSRD 90

  Fly    82 PKILDKVTKKNGTNIPELDKRSLTIC----SNTDYINITYHHVICPDAAT-----AKIWLDGIR- 136
            .:...:.|:|       ||   .|:|    ..||:      .:....||.     ..:|:.|:.
Frog    91 FERYPEDTRK-------LD---ATLCFIILYGTDF------RLKTVSAAAFSEEEVNLWISGLNW 139

  Fly   137 KITHNVKANNICPMMCLRKHWMRLSY-CVEKS--GKIPVKTLAKTFASGKTEKLVYTCIKDAGLP 198
            .:...:||..  |:...|  |:...: .|:::  |.:.||.|     .....::.|.......|.
Frog   140 VVADTLKAPG--PLQIER--WLGKQFNAVDRAREGSVTVKDL-----KALLPQVNYRVPNMRFLR 195

  Fly   199 DDKNATMTKEQFTFDKFYALYHKV---CPRNDIEELFTSITKGKQD-----FISLEQFIQFMNDK 255
            |.......:.:.||..|...|:.:   ..::.||:|..|......|     .|||..|.:|:...
Frog   196 DKMLEIEARSELTFPHFVLFYNNLMFDAQKSIIEQLELSFPLRNVDRPSLCQISLYDFQRFLQFD 260

  Fly   256 QRDPRMNEILYPLYEEKRCTEIINDYELDEEKKK-NVQMSLDGFKRYLMSDENAPVFLD-RLDFY 318
            |::....:|       .:....:.:|..|.:... ...:.||.|..||.|.||  :.:| |.:..
Frog   261 QKEAWAGDI-------NKVRGYLCNYLKDSDGDVCEPILQLDEFLTYLFSKEN--MIMDSRFEQV 316

  Fly   319 M--EMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTH 381
            :  ||..||:.|:|:|||||||:|.|...:||:|.|.:.|..||||:|||||:  |.|:.||:.|
Frog   317 VPEEMTYPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWD--GPDDLPIIYH 379

  Fly   382 GHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDH 446
            ||...::|.|.|.:..|.|.|||:||||||||.|:||:..||..:|.|....|||:||.:|: |.
Frog   380 GHTLTSKIKFLDVLHTIKDNAFVTSEYPVILSIEDHCSVVQQRNMAHYFRKVFGDMLLTKPV-DI 443

  Fly   447 PLDPGLPLPPPCKLKRKILIKNKRM---------------------------------------- 471
            ..|   .||.|.:||:|||||:|::
Frog   444 NAD---ELPSPAQLKKKILIKHKKLVEGNLYEEVSTASYSENDISNSIKNGILYLEDPIDHTWSP 505

  Fly   472 ------------------------------KPEVEKVEL---ELWLKGELKTDDDPEEDA----- 498
                                          |.|....||   |.|..|:|....|..:.|
Frog   506 HYFVLTSNKIYYSEETSRYQSNDEDEEMEPKEEFNNNELHFSEKWFHGKLGGGRDGRQIAEKLLH 570

  Fly   499 -----SAGKP---------------------------------PEAAAA---------------- 509
                 :.||.                                 .||.:.
Frog   571 EYCTETGGKDGTFLVRESETFVGDYTLSFWRSSRVQHCRIHSRQEAGSTKFYLTDNLVFDSLYGL 635

  Fly   510 --------------------PAPAPEAAAAAE---------------------GA---------- 523
                                |.|.|.|..:.|                     ||
Frog   636 ISHYREVPLRCNEFEMRLTDPVPQPNAHESKEWYHANLTRLQAEHMLMRVPRDGAFLLRKRSETS 700

  Fly   524 -------AEG----------------GGGAEAEAAA----------------------------- 536
                   |||                |..||.|:..
Frog   701 SFAISFRAEGKIKHCRIQQEGRLFMLGSSAEFESLVDLISYYEKHPLYRKMRLRYPINEEALEKM 765

  Fly   537 ----------------------------------------------------------------- 536

Frog   766 GTAELDYDALFEGRTPHVYVEANKMPTSRCTVKALYDYKAQREDELTFCKQAIIHNVDKQDGGWW 830

  Fly   537 -------------ANYSGSTTNV------------------------------------------ 546
                         |||...||:.
Frog   831 RGDYGGKKQLWFPANYVEETTSAMSPDQDEGSFYFGQSVENSPLGNFLKGFIDVPSCHIVSSKDG 895

  Fly   547 ----------------HP----------------W------------------------------ 549
                            ||                |
Frog   896 RSSRPYVFTIHSQQMSHPSQSLDVAADTQEELNDWIGKIREATQNADARMQEGKIMERRKKIALE 960

  Fly   550 LSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQS-SIDFVNYNKRQMSRIYPKGTR 613
            ||.:|.|.:|:.|.......||....:||||.|:....|..:| ...|:.||:||:||:||||.|
Frog   961 LSELVVYCRPVPFDEEKIGTEKACYRDMSSFPETKAEKYANRSKGKKFLQYNRRQLSRVYPKGQR 1025

  Fly   614 ADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADA 678
            .|||||.|...|..|.|:|:||||:.|.||||||..|...|..||:|:||.||  |..||||...
Frog  1026 LDSSNYDPLPMWICGSQLVALNFQTPDKPMQLNQALFMLGGQSGYVLQPDIMR--DDLFDPFDKN 1088

  Fly   679 PVDGVIAAQCSVKVIAGQFLSDKK---VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED 740
            .:..|......::::..:.|....   |..::||::.|...|..|.  ::.:||:||||||:...
Frog  1089 SLKIVEPITVQLQILGARHLPKNGRSIVCPFIEVEVCGSEFDNSKS--KSDVVADNGLNPVWMMK 1151

  Fly   741 PFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFV 801
            .||| .:..|:.|.|||.||||    ....|.|....:.||:.|||.|.||...:..:.|..|.|
Frog  1152 QFVF-DITNPEFAFLRFVVYEEDMFSDPNFLAQATFSVKGLKTGYRSVPLRNSYSEELELASLLV 1215

  Fly   802 NIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPL 866
            :||:.                      .||:::::.....|::....|:..:.:....|:..
Frog  1216 HIEIV----------------------NAKEEDDENLYTSIQQLRDRASELSSQVSSYERAN--- 1255

  Fly   867 VFEPVTLESLRQEKGFQKVGKKQIKELDTLR--KKHAKERTSVQKTQNAAIDKLIKGKSKDDIRN 929
                 ..:|..|::            ||.||  ::...|.|.|:..      ||::.|.::  |.
Frog  1256 -----NCDSRYQQR------------LDELRAAQERLMELTEVRNR------KLMEKKKRE--RQ 1295

  Fly   930 DANIKN 935
            .||.:|
Frog  1296 LANKRN 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	29/141 (21%)
		PLN02952	224..786	CDD:178538	236/995 (24%)
		EF-hand_like	227..318	CDD:286375	24/97 (25%)
		PI-PLCc_beta	318..653	CDD:176533	163/754 (22%)
		C2_PLC_like	689..806	CDD:175974	42/123 (34%)
		DUF1154	866..908	CDD:284131	8/43 (19%)
		Mer2	<887..1003	CDD:286200	14/51 (27%)
LOC100496658	XP_017950677.1	PH_PLC_gamma	30..151	CDD:270168	29/142 (20%)
		EFh_PI-PLCgamma1_like	156..305	CDD:320046	33/160 (21%)
		EF-hand motif	156..185	CDD:320046	6/33 (18%)
		EF-hand motif	193..220	CDD:320046	6/26 (23%)
		EF-hand motif	226..261	CDD:320046	10/34 (29%)
		EF-hand motif	271..305	CDD:320046	8/33 (24%)
		PI-PLCc_gamma	318..>453	CDD:176534	70/140 (50%)
		PH-like	487..>523	CDD:388408	0/35 (0%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	10/103 (10%)
		SH2_C-SH2_PLC_gamma_like	663..766	CDD:198186	10/102 (10%)
		SH3_PLCgamma	796..849	CDD:212759	3/52 (6%)
		PH-like	<860..941	CDD:388408	3/80 (4%)
		PLCYc	962..1077	CDD:128454	54/114 (47%)
		C2_PLC_like	1095..1219	CDD:175974	41/126 (33%)
		Smc	<1201..>1301	CDD:224117	26/149 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010