DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plcl2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_002932453.1	Gene:	plcl2 / 100489093	XenbaseID:	XB-GENE-949595	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	1118	Identity:	290/1118 - (25%)
Similarity:	454/1118 - (40%)	Gaps:	244/1118 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKSEGRDGD--VIELCQVSDIRAGGTPKDPKILDKVTKKNG 93
            |:.:.|.......|.:|.....|.|:...:|.:  .|::..|.::|.|      |..| :.:.||
Frog   137 KKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSVKEVRTG------KNTD-IFRSNG 194

  Fly    94 TNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWM 158
            ......:..:.:|....:|.::   .::...|..|.:|:.|:|.:....|  :...|:...:..|
Frog   195 IYDQISEDCAFSIIYGENYESL---DLVANSADVANVWVTGLRYLISYGK--HTLDMIESFQDNM 254

  Fly   159 RLSYC--------VEKSGKIP-------VKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKE 208
            |:|:.        .|.:|.||       :|.|.....:.|.|      :|...|...|....|
Frog   255 RISWLSQMFRELDEENTGDIPLCKAVQFIKNLNPGLKNSKIE------LKFKELQKSKEKVST-- 311

  Fly   209 QFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKR 273
            :.|.|:|..::|::|.|.:|..|....:..| :::..:..:.|:..:|....:.|.:
Frog   312 EVTKDEFIEVFHELCTRPEIYFLLVQFSSNK-EYLDTKDLMMFLEAEQGMAHVTEEI-------- 367

  Fly   274 CTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYL 338
            ..:||..|| ..:.::...:||||...||||.:.:....:......:|.|||:|||||:||||||
Frog   368 SLDIIKKYE-PSKGQETGSLSLDGLTSYLMSPDCSIFDPEHKKICQDMAQPLSHYYINASHNTYL 431

  Fly   339 SGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAF 403
            ...|..|.|.:..|.:.|..|||.||||.|:  |.|.||::..||...::|:|:..|:.|...|.
Frog   432 IEDQFRGPSDITGYIRALKMGCRSVELDVWD--GPDNEPVIYTGHTMTSQIVFRSVIEIINKYAV 494

  Fly   404 VSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKN 468
            .:||||:||..||||:..||..:.::.....||.|    ....|......||.|..||.|:|||.
Frog   495 YASEYPLILCLENHCSVKQQKVMVQHMKKILGDKL----YTTSPNSEESYLPSPESLKGKLLIKG 555

  Fly   469 KRMKPEVEKVELELWLKGELKTDDDP--EEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAE 531
            |::..:...:|      |:: ||:|.  |.....||..|.....||........|
Frog   556 KKLNSDCSGIE------GDV-TDEDEGLEMSQRVGKDGEEQQNTAPVKRVQLCKE---------- 603

  Fly   532 AEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDF 596
                              ||.:|:..:.::|..|..:.:......:.||.|.|...|..::..||
Frog   604 ------------------LSDLVSICKSVQFTDFQISFQNQKYWEVCSFNEVAAGKYANENPGDF 650

  Fly   597 VNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLK 661
            ||||||.:|||:|...|.||||..||.:|..|||:|::|:|:..|.|.||.|.|..||.|||:|:
Frog   651 VNYNKRYLSRIFPSPMRIDSSNMNPQDYWKCGCQIVAMNYQTPGLMMDLNIGWFRQNGNCGYVLR 715

  Fly   662 PDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKK--------VGTYVEVDMFGLPSDT 718
            |..||.....|.......|.||......:|:|:||.....|        |..||.|::.|:|:|.
Frog   716 PSIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADC 780

  Fly   719 VKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEE---SGKILGQRILPLDGLQAG 780
            .  |.||:.|..||.||:::|. |.| ::.||:|.::||.|.::   ..:.:||..:|.:.||.|
Frog   781 A--EQRTKTVHQNGDNPIFDES-FEF-QINLPELTMVRFVVLDDDYIGDEFIGQYTIPFECLQPG 841

  Fly   781 YRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQ 845
            ||||.|::.....:....|||::                                     .|..:
Frog   842 YRHVPLQSLTGDILPHASLFVHV-------------------------------------AITNR 869

  Fly   846 SGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKT 910
            .||                                     ||...:.|...:.|.:::..|::..
Frog   870 RGG-------------------------------------GKPHKRGLSVRKAKKSRDYASLRTL 897

  Fly   911 QNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALML 975
            ...::|::.|           |....|.|.|.                ||:::|::..:.|.|..
Frog   898 LIKSVDEVFK-----------NAIQPIRDATD----------------LRENMQNTVVSFKELCG 935

  Fly   976 TVQAAQIKQ----LEDRHARD------IKDLNAKQAKMSAD-TAKEV------------QNDKTL 1017
            ....|.::|    |..|.|..      :.:||.:...|... |..||            ||.|||
Frog   936 LSPVANLRQCIMALSTRLAGPDNTPVVVMNLNEQYPTMELQGTVPEVMKRILAAYDSIIQNSKTL 1000

  Fly  1018 KTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKL---MDMYK 1079
            ....:.......:.|.....|.|....||.|:|....|:    .|.:|.|:.::..|   .|:.|
Frog  1001 IENADGVYEKIVQCQKTAMEFHENLSSIGAKEGLKERKM----LKAVESFTWNITILKGQADLLK 1061

  Fly  1080 IEEEAYKTQGKTE 1092
                    ..|||
Frog  1062 --------YAKTE 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	23/119 (19%)
		PLN02952	224..786	CDD:178538	190/574 (33%)
		EF-hand_like	227..318	CDD:286375	18/90 (20%)
		PI-PLCc_beta	318..653	CDD:176533	119/336 (35%)
		C2_PLC_like	689..806	CDD:175974	43/127 (34%)
		DUF1154	866..908	CDD:284131	5/41 (12%)
		Mer2	<887..1003	CDD:286200	22/125 (18%)
plcl2	XP_002932453.1	PH_PLC_eta	130..238	CDD:270170	22/110 (20%)
		EFh_PI-PLC	258..400	CDD:333715	36/159 (23%)
		EF-hand motif	258..287	CDD:320029	5/28 (18%)
		EF-hand motif	294..325	CDD:320029	10/38 (26%)
		EF-hand motif	330..358	CDD:320029	4/28 (14%)
		EF-hand motif	367..399	CDD:320029	12/40 (30%)
		PI-PLCc_PRIP_metazoa	411..707	CDD:176539	119/336 (35%)
		C2_PLC_like	739..867	CDD:175974	43/168 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010