DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and plch2

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_031761350.1	Gene:	plch2 / 100487353	XenbaseID:	XB-GENE-988591	Length:	1578	Species:	Xenopus tropicalis

Alignment Length:	1179	Identity:	294/1179 - (24%)
Similarity:	486/1179 - (41%)	Gaps:	288/1179 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKIL 85
            |:  ||    :.:::|:..:.::..:.|.       .||:..::.:       |......||...
Frog    72 CI--RW----RPSRKNEKAKISIDSIQEV-------CEGKQSEIFQ-------RYADGSFDPNCC 116

  Fly    86 DKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVK-ANNICP 149
            ..:  ..|.::..||                   ::......|:.|:.|::.:...:. .:::..
Frog   117 FSI--YYGDHMESLD-------------------LVSSSGEEARTWITGLKYLMAGISDEDSLSK 160

  Fly   150 MMCLRKHWMRLSYC-VEKSGK--IPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFT 211
            ....|..|::.::. .:|:|.  :.:..:.:..     .||      :..||..|...|.||..|
Frog   161 RQRTRDQWLKQTFDEADKNGDGCLSINEVLQLM-----HKL------NVNLPRQKVKQMFKEADT 214

  Fly   212 --------FDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPL 268
                    ||:|.|.|..:..|.|:..|..:.:..| |.:..:...:|:..:|:...:.
Frog   215 DDNQGTLGFDEFCAFYKMMSTRRDLYLLMLTYSNHK-DHLDPDDLKRFLEVEQKMINVT------ 272

  Fly   269 YEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSS 333
              ::.|.:|::.:|...|.||...:.:|||..|:.|........|......:|..||::|:|.||
Frog   273 --KEYCLDIVDKFEPCPENKKQGALGIDGFTNYMRSPAGDIFNPDHYQVNQDMTLPLSNYFIASS 335

  Fly   334 HNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAI 398
            |||||.|.|:..:|.|:||...|.|||||||:|||:  |.|.||||.||:...::|||||.|:.|
Frog   336 HNTYLMGDQLMSQSRVDMYAWVLQAGCRCVEVDCWD--GPDGEPIVHHGYTLTSKILFKDVIETI 398

  Fly   399 ADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRK 463
            ...||:.::||||||.||||:..||.|:|:|..:..|:   |..|.|...:....||.|..|:.|
Frog   399 NKYAFIRNDYPVILSIENHCSVVQQKKMAQYLIEILGE---KLNLSDVVNEDSTKLPSPESLRGK 460

  Fly   464 ILIKNKRM--------------------------------------KPEVE---KVELELWLK-G 486
            ||:|.|::                                      :.:||   |.:|:..|| .
Frog   461 ILVKGKKLPASISDDAEEGDVSDEDSADEIDDDCKLINGDWKASANRKQVENIAKKKLDSLLKES 525

  Fly   487 ELKTDDDPEEDASAGKPPEAAAAPAP-----------APEAAAAAEGAAEGG------------- 527
            :::..:||........||....:..|           ...|.:..|..||.|
Frog   526 KIRDREDPNNFTVTTLPPSGKLSQKPELKKKCSSGSKGERALSKTEEEAESGEEPSPNKRHSRSL 590

  Fly   528 ----------GG-----------------------AEAEAAAANYSGSTTNVHPWLSSMVNYAQP 559
                      ||                       |....:..|....|..:...||.:|.|.:.
Frog   591 IGSFSKHKKKGGKIKKCSSLEEGDESLDRQGSLARASVHYSRINRQKKTMKLSRALSDLVKYTKS 655

  Fly   560 IKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVF 624
            :...  |...|.:.:..:|||:|:.....|:|....||.:|:.|:|||||...|.|||||.||.|
Frog   656 VGIH--DVETEISCSWQVSSFSETKAHQILQQKPAQFVRFNQHQLSRIYPSSYRVDSSNYNPQPF 718

  Fly   625 WNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCS 689
            ||||||:|:||:||....:|||:.||..||.|||:|||..|  ....|:|.::.|:.|.:..|..
Frog   719 WNAGCQLVALNYQSEGRMLQLNRAKFNSNGNCGYVLKPKCM--CQGAFNPNSEDPLPGQLKKQLV 781

  Fly   690 VKVIAGQFLSDKK----------VGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVF 744
            :::|:||.|...|          :..:|||::.|||.|..|::  ||:|.:||.||:: |:..||
Frog   782 LRIISGQQLPKPKDSMLGDRGEIIDPFVEVELIGLPVDCFKEQ--TRVVDDNGFNPMW-EETLVF 843

  Fly   745 RKVVLPDLAVLRFGVYEES--GK-ILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELK 806
             .|.:|:::::||.|::..  |: .:|||.|....:..|||||.|.     .|....:||::.:
Frog   844 -TVHMPEISLIRFLVWDHDPIGRDFIGQRTLSFSSMMPGYRHVYLE-----GMEEASIFVHVAI- 901

  Fly   807 IYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPV 871
                   .|....:....|..|...:..:|            |:.|:..|.:..:|      ..:
Frog   902 -------NDISGKVKQAAGLKGLFLRNPKQ------------ASLDSHAAGQLHRK------HSI 941

  Fly   872 TLESLRQ-----EKGFQKVGKKQIKELDTLRKKHAKERTSV-QKTQNAAIDKLIKG--------K 922
            :...||:     .||.|| .||...|:....|:::.:..|. ::|.::::.:..|.        .
Frog   942 SSHILRRTASAPTKGQQK-NKKGFPEIAIDSKENSSDGPSEDRETDDSSLPRFEKDPESASPALP 1005

  Fly   923 SKDDIRNDANIKNSIND----------------QTKQWTDMIARHR------------------- 952
            |:|....:.|.| .:.|                :|.:...:.|:.:
Frog  1006 SRDGTNVELNSK-GLKDPRQLSIYRSASSLCSLETIKEEPLFAKEKPSTSPQPVACFTSCESTAC 1069

  Fly   953 ---KEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQND 1014
               ||...........|::..:...|.|:.|.||.|...:.     |:....|::...|...:|.
Frog  1070 DQYKESQSECSSPAITSENVQRPSKLNVEPAIIKVLAISNG-----LHPHNGKLNPGKAYNDRNG 1129

  Fly  1015 KTLKTKNEK 1023
            |.|.:.:.|
Frog  1130 KVLSSVSGK 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	16/128 (13%)
		PLN02952	224..786	CDD:178538	212/673 (32%)
		EF-hand_like	227..318	CDD:286375	18/90 (20%)
		PI-PLCc_beta	318..653	CDD:176533	141/433 (33%)
		C2_PLC_like	689..806	CDD:175974	42/129 (33%)
		DUF1154	866..908	CDD:284131	11/47 (23%)
		Mer2	<887..1003	CDD:286200	24/162 (15%)
plch2	XP_031761350.1	PH_PLC_eta	44..150	CDD:270170	16/118 (14%)
		EFh_PI-PLCeta2	168..308	CDD:320051	35/159 (22%)
		PI-PLCc_GDPD_SF	320..747	CDD:417475	141/433 (33%)
		C2_PLC_like	777..901	CDD:175974	43/132 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010