DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment norpA and plcd4

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_002933984.2	Gene:	plcd4 / 100379715	XenbaseID:	XB-GENE-965137	Length:	758	Species:	Xenopus tropicalis

Alignment Length:	804	Identity:	247/804 - (30%)
Similarity:	384/804 - (47%)	Gaps:	109/804 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTN 95
            ::.|...:::...||:.| .....|.:..:.|:......:|||.........::|..:..:..
Frog    25 RKVKSRSWKKQRYFKLQE-DCMTIWYNSKKTGNTKSTFSISDIETVREGHQSEVLQSIADEFK-- 86

  Fly    96 IPEL--------DKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNV----KANNIC 148
             |||        .:.:|.:.:||            |:  .|:.|:.|:.|:...|    :.:.:.
Frog    87 -PELCFTIVFHGRRANLDLVANT------------PE--EAQCWIQGLEKLIETVTNMDQKDLLD 136

  Fly   149 PMMCLRKHWMRLSYCVEKSGKI---PVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQF 210
            ..:|   .|.:.: ...|.|::   .|:.|.|......:|...|...:.|    ||:.:.|.|.
Frog   137 QWIC---DWFQKA-DKNKDGRMNFKEVQDLLKMMNVDMSEHHAYRLFQMA----DKSESGTLEG- 192

  Fly   211 TFDKFYALYHKVCPRNDIEELFTSITK-GKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRC 274
              ::|...|..:..|:::.::|...:| ||:  ::|.:|:.|:...|.:....|.|        .
Frog   193 --EEFVLFYKALTQRDEVLKIFQDFSKDGKK--LTLLEFVDFLQQGQLEEENTEEL--------A 245

  Fly   275 TEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLS 339
            .::|..||..:..||...||:|||..||.|.|.:...:.....|.:|.|||.||:|:|||||||.
Frog   246 MDLIARYEPSDTAKKLHAMSIDGFVMYLCSPEGSIFNVAHEQLYQDMTQPLCHYFISSSHNTYLM 310

  Fly   340 GRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFV 404
            ..||.|:||||.|.:.|..||||||:|.|:  |.:.||||.||..:.::|||||.|.||...||.
Frog   311 EDQIRGQSSVEGYIRALKRGCRCVEVDTWD--GPNGEPIVYHGRTFTSKILFKDVISAINKYAFR 373

  Fly   405 SSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLP--LPPPCKLKRKILIK 467
            ..:||||||.||||...||..:|::.....|..|:..     .||..:|  ||.|.:|:.|||:|
Frog   374 VCDYPVILSLENHCGVEQQDAMAQHLKSILGTKLIMS-----TLDGRIPTCLPSPDELRGKILLK 433

  Fly   468 NKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEA 532
            .|::              |.|....:.:.|.|.|:..:       ..|.....|...|....|:.
Frog   434 GKKI--------------GRLVDSLEEQPDDSVGEVTD-------EEENVEVEEERNEDKKRAKK 477

  Fly   533 EAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFV 597
                     |...:...||..|.|.:.:.|..|..:......:.|||..|......:::...|||
Frog   478 ---------SKERLSHLLSDCVIYCKSVPFVSFQHSRAHYTLYEMSSVTEYKARKLVREPGNDFV 533

  Fly   598 NYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKP 662
            .:|..|:.|:||.|.|.|||||.||..||.|||||:||||::.:.|.||.|.|..|..|||:|||
Frog   534 RHNAWQLMRVYPTGLRTDSSNYNPQEMWNVGCQMVALNFQTAGVEMDLNDGLFRQNARCGYVLKP 598

  Fly   663 DFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFL---SDKKVGT----YVEVDMFGLPSDTVK 720
            .|||..:..|:|......:|......|:.||:.|.|   .:.|.|:    :|.|::||:|.|..|
Frog   599 SFMRHVETTFNPDQPQSTEGYSPVNLSILVISAQQLPKVENSKEGSIVDPFVRVEIFGVPIDQTK 663

  Fly   721 KEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGV--YEESGK--ILGQRILPLDGLQAGY 781
            :|  |:.:.|||.||::.|.  :..|:.:|:||::||.|  |:::.:  .:||..||...:::||
Frog   664 QE--TKYIENNGFNPMWYET--LHFKIHVPELALVRFVVEDYDKTSRNDFVGQYTLPFKSIKSGY 724

  Fly   782 RHVSLRTEANFPMSLPMLFVNIEL 805
            ||:.|.:.....|....:||::.:
Frog   725 RHIHLLSRDGTKMPPASVFVHVRV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	22/129 (17%)
		PLN02952	224..786	CDD:178538	205/575 (36%)
		EF-hand_like	227..318	CDD:286375	24/91 (26%)
		PI-PLCc_beta	318..653	CDD:176533	129/336 (38%)
		C2_PLC_like	689..806	CDD:175974	42/128 (33%)
		DUF1154	866..908	CDD:284131
		Mer2	<887..1003	CDD:286200
plcd4	XP_002933984.2	PH_PLC_delta	18..133	CDD:270169	22/125 (18%)
		EFh_PI-PLCdelta4	138..277	CDD:320049	40/159 (25%)
		PI-PLCc_delta4	289..589	CDD:176568	129/336 (38%)
		C2_PLC_like	621..749	CDD:175974	42/132 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010