DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment norpA and LOC100149080

DIOPT Version :9

Sequence 1:	NP_001014720.1	Gene:	norpA / 31376	FlyBaseID:	FBgn0262738	Length:	1095	Species:	Drosophila melanogaster
Sequence 2:	XP_021324223.1	Gene:	LOC100149080 / 100149080	-ID:	-	Length:	918	Species:	Danio rerio

Alignment Length:	1165	Identity:	291/1165 - (24%)
Similarity:	473/1165 - (40%)	Gaps:	375/1165 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VPPELTTGCVFDRWFENEKETKENDFE--RDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRA 75
            ||..|:||..|.:|        ::|..  ......||..|::|||..:.::.|::::..:.|.|.
Zfish    18 VPERLSTGEKFMKW--------DDDCTSGTPVTLYVDPQGYYLYWTDQNKETDLLDISLIKDTRT 74

  Fly    76 G---GTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRK 137
            |   .||:|.::.:::..  |....:::.|.||:...:|.:||::.:........||.|...:..
Zfish    75 GRFAKTPRDVRLREQLDV--GALQGQMEDRLLTVVCGSDMVNISFLNFCAFHEDVAKEWAKELFT 137

  Fly   138 ITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKN 202
            :..|:.|.|:.....|.|.:.||:..:...|.||||.:.....:.:  :.|.:.::...||..:|
Zfish   138 LASNLLAQNLSRESSLEKVYSRLTLQLTTWGSIPVKNIFPLLPADR--RRVESALEVCSLPTGRN 200

  Fly   203 ATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYP 267
            .::..:.||.|.:..|.:.:||||||:.:|:.|....:.::::||...|:|:||||.|:||||||
Zfish   201 DSIPLDTFTQDVYRQLLNNICPRNDIDTIFSDIGAKSRPYLTVEQMTDFLNNKQRDSRLNEILYP 265

  Fly   268 LYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINS 332
            ..:.::...::..||.|.......|:|::||.|||..:||..:..::||...::.|||:||:|||
Zfish   266 HLKAEQVQALVEKYEPDSMLSSRGQISVEGFARYLSGEENCIIPPEKLDLSEDITQPLSHYFINS 330

  Fly   333 SHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQA 397
            ||||||...|:.|.||||:|||.||:||||||||.|.||..|||||:|||....|||.||
Zfish   331 SHNTYLIAGQLAGTSSVEIYRQVLLSGCRCVELDVWKGKAPDEEPIITHGFTMTTEISFK----- 390

  Fly   398 IADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKR 462
                                     |.|:|:||...|||.||.:||..:|
Zfish   391 -------------------------QAKMAEYCRKIFGDALLIDPLEKYP--------------- 415

  Fly   463 KILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGG 527

Zfish   416 ----------------------------------------------------------------- 415

  Fly   528 GGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQS 592

Zfish   416 ----------------------------------------------------------------- 415

  Fly   593 SIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCG 657
                                                |..||
Zfish   416 ------------------------------------CSSVS------------------------ 420

  Fly   658 YLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKE 722
                                             ::|:|||||:|:||.||||:|.|||.||..|.
Zfish   421 ---------------------------------QIISGQFLSEKRVGVYVEVEMIGLPVDTRWKA 452

  Fly   723 FRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLR 787
            |||:....|.:|||::|:|.:|::||||.||.||...||::|:.:|.||:|:..::.|||::|||
Zfish   453 FRTKSSQGNAINPVWDEEPMIFKRVVLPTLASLRITAYEDNGRCIGHRIIPVCAIRPGYRYISLR 517

  Fly   788 TEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEE-------- 844
            .|.|..::||.:|:..|:|.||||.:.|.:..||:|..:....:|::.|:..|..||
Zfish   518 NERNQTLTLPSIFIYSEVKDYVPDTYADVIEALSNPIHYVNLMEQRSHQLAVLTQEEGEMETDGD 582

  Fly   845 QSGGAARDAGKAKEEEK-----------------------KEPPLVFEPVT-----------LES 875
            |..|......:.|..|.                       .:|....|.||           :|.
Zfish   583 QVNGGVESVSEVKTSENGLNHNSLSPRSSVQIHQTPSSGPVKPTAKSESVTQSALAEVQAQSVEE 647

  Fly   876 LRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKG----------KSKDDIRND 930
            |:|:|.|.:..|||.|||..|.|||.|: ||...:::||..|.:..          |::..:..|
Zfish   648 LKQKKAFTRQQKKQYKELKDLMKKHHKQ-TSELISEHAARQKQLHSEFLRQRVALQKTRSVLSQD 711

  Fly   931 ANIK----NSINDQTKQWTDMIARHRKEEW----DMLRQHVQDSQDAMKALMLTVQAAQIKQLED 987
            |.::    :.:::..:|...|:.:.|:|::    ...::|.:...:.:.::....|:.|:|:|::
Zfish   712 AALQQQESSRLSELKEQQQQMLLKLRQEQYYKEKYCKQEHAKQLVEKLVSVAEHCQSNQLKKLKE 776

  Fly   988 RHARDIKDLNAKQAKMSADTAKEVQ-NDKTL--KTKNEKDR----------------------RL 1027
            ...::.|||..|..|...:...|.: ..|||  :||.|.|:                      .|
Zfish   777 LSEKESKDLKKKMDKQRQEKLNEARAQGKTLTEETKMEMDKAHVNEVVQAVHRLQGAQNTRLESL 841

  Fly  1028 REKRQNNVKRFMEEK----KQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEE 1083
            ::|.:...::.:|||    .|:..:......:|.|...:.::|..:.||...|...:|::
Zfish   842 QKKHEEIKQQILEEKVKLQTQLDQEYQDKFRRLPLEIQEFVQESESGVQSRRDSAAVEKQ 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_001014720.1	PH_PLC_beta	17..149	CDD:270167	32/136 (24%)
		PLN02952	224..786	CDD:178538	149/561 (27%)
		EF-hand_like	227..318	CDD:286375	33/90 (37%)
		PI-PLCc_beta	318..653	CDD:176533	65/334 (19%)
		C2_PLC_like	689..806	CDD:175974	57/116 (49%)
		DUF1154	866..908	CDD:284131	21/52 (40%)
		Mer2	<887..1003	CDD:286200	32/133 (24%)
LOC100149080	XP_021324223.1	PH_PLC_beta	22..149	CDD:270167	32/136 (24%)
		EFh_PI-PLC	154..304	CDD:333715	49/151 (32%)
		EF-hand motif	154..183	CDD:320029	8/28 (29%)
		EF-hand motif	187..215	CDD:320029	6/27 (22%)
		EF-hand motif	225..254	CDD:320029	8/28 (29%)
		EF-hand motif	271..304	CDD:320029	10/32 (31%)
		PI-PLCc_GDPD_SF	316..>415	CDD:326331	61/128 (48%)
		C2_PLC_like	421..536	CDD:175974	57/114 (50%)
		DUF3084	560..>746	CDD:331293	41/186 (22%)
		DUF1154	644..688	CDD:310911	20/44 (45%)
		PLC-beta_C	720..888	CDD:312287	31/167 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010