Protein Alignment norpA and plcb4

DIOPT Version :10

• Sequence 1: NP_525069.2
• Gene: norpA / 31376
• FlyBaseID: FBgn0262738
• Length: 1095
• Species: Drosophila melanogaster
• Sequence 2: XP_002931782.1
• Gene: plcb4 / 100125098
• XenbaseID: XB-GENE-1010443
• Length: 1205
• Species: Xenopus tropicalis
• Alignment Length: 1191
• Identity: 609/1191 - (51%)
• Similarity: 790/1191 - (66%)
• Gaps: 114/1191 - (9%)

  Fly     1 MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVI 65
            |.|.|||:|...||..:..|.||||:     |.:...||.:.||||||:||||.|||||::|.|:
 Frog     1 MAKVYEFNWQKAVPSFMQDGAVFDRY-----EEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL 60

  Fly    66 ELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKS 130
            |...::.||.|..|||||||..: :..|....|||.:.|.:|..||.:||::.:::...|..||.
 Frog    61 ECSLINSIRYGAVPKDPKILSAL-EAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQ 124

  Fly   131 WQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDA 195
            |.:.|:.||||.||.||.|...|.||||:|::....||||||:::.:|||||||||:::..:|:.
 Frog   125 WVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKEL 189

  Fly   196 GLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPR 260
            |||..||..:....|||||||.|..|:|||.|.||||..|...|.|:::::|.:.|:|:.|||||
 Frog   190 GLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPR 254

  Fly   261 MNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPL 325
            :||||:|.::.||..:||..||.|||.||..|:|..||.||||||||||||||||:.|.||:.||
 Frog   255 LNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPL 319

  Fly   326 AHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEIL 390
            |||:|:|||||||:|||.|||||||||||.|||||||||||||:|||||:|||:|||.|.||:||
 Frog   320 AHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDIL 384

  Fly   391 FKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLP 455
            |||.||||.|.|||:|||||||||||||::.||||::|||::.||||||.:.|..||||.|.|||
 Frog   385 FKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLP 449

  Fly   456 PPCKLKRKILIKNKRMKPEVEKVELELWLK-----GELKT------DDDPEEDASAGKPPEA--- 506
            .|..|||||||||||:|.||||.:||. ||     ||..|      ||..||..:|.:..||
 Frog   450 SPNDLKRKILIKNKRLKAEVEKKQLEA-LKSMMEAGETATPVSILEDDIEEEIENADQEEEAHPE 513

  Fly   507 -------AAAPAPAPEAAAAAEGAAEGG-------GGA------EAEAAAANYSGSTTNVHPWLS 551
                   ::......|||..|:..||..       .||      :|..|:..|.|:|||:||:||
 Frog   514 FKFGSELSSDDLSQKEAANIAKKMAEDAEQENNNKKGAITVEDEQAWMASYKYVGATTNIHPFLS 578

  Fly   552 SMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADS 616
            ||:|||||:|||||..|.|:||..|||||.||.|:.|||..:::||||||||||||||||.|.||
 Frog   579 SMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDS 643

  Fly   617 SNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVD 681
            ||||||:||||||||||||:|:.||.||||||||||||.||||||||||||.|:.||||::.|||
 Frog   644 SNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVD 708

  Fly   682 GVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRK 746
            |||||.|||:||:||||||||:||||||||:|||:||::||||||:|.|||||||||::||||||
 Frog   709 GVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNDEPFVFRK 773

  Fly   747 VVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPD 811
            |:||||||||..||:::.|::||||||||||||||||:|||.|.|.|:|||.:|.||.||.||||
 Frog   774 VILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPD 838

  Fly   812 GFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------EQSGG 848
            ||.|.:..||||:.|....:::.:||:|:|||                            .||..
 Frog   839 GFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPADNTKNDKKGKTSNAKTNVTPQSSS 903

  Fly   849 AARD----AGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQK 909
            ..|.    |..|..|.||  .:....|.:|.|:|.|.|.|..|||.||:..|:|||.||.:.|||
 Frog   904 EVRPSVTAAPGAGTENKK--AIDIPQVKVEELKQMKAFLKQQKKQQKEIAALKKKHLKEHSVVQK 966

  Fly   910 TQNAAIDKLIKGKSKDDIRNDANIKNSI-----------------------NDQTKQWTDMIARH 951
            .|...:||::....|:.:.::..::.||                       :|...:..|::|:|
 Frog   967 LQCTQVDKIVAQFDKEKVSHERTLEKSIKKKGASNCHEMKKETENKIQVLTSDHKSKVKDIVAQH 1031

  Fly   952 RKEEWDMLRQ-----------HVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSA 1005
            .||..:|::.           |:....:.:|.|:..:.|.|::||:..|.|:.|::.|.|||:|.
 Frog  1032 TKEFTEMVKAQNAEEQTLRDVHLSQQCELLKELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSM 1096

  Fly  1006 DTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTD 1070
            :..|.:..||::|.|.|::||:||...:|.|:|:||:|::.:||.:.:::|    .|..:|...:
 Frog  1097 ENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKDVDQL----LKNQQEHMEN 1157

  Fly  1071 VQKLMDMY-KIEEEAYKTQGK 1090
            ::|..:.: |......::|||
 Frog  1158 LEKQNEQHLKACHAVSQSQGK 1178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
norpA	NP_525069.2	PH_PLC_beta	17..149	CDD:270167	59/131 (45%)
		EFh_NorpA_like	154..306	CDD:320042	79/151 (52%)
		EF-hand motif	154..183	CDD:320042	15/28 (54%)
		EF-hand motif	189..218	CDD:320042	13/28 (46%)
		EF-hand motif	227..256	CDD:320042	11/28 (39%)
		EF-hand motif	273..306	CDD:320042	19/32 (59%)
		PI-PLCc_beta	318..653	CDD:176533	231/368 (63%)
		C2_PLC_like	689..806	CDD:175974	87/116 (75%)
		DUF1154	865..909	CDD:461969	19/43 (44%)
		PLC-beta_C	952..1073	CDD:462571	39/131 (30%)
plcb4	XP_002931782.1	PH_PLC_beta	17..143	CDD:270167	59/131 (45%)
		EFh_PI-PLCbeta4	148..300	CDD:320041	79/151 (52%)
		EF-hand motif	148..177	CDD:320041	15/28 (54%)
		EF-hand motif	183..212	CDD:320041	13/28 (46%)
		EF-hand motif	221..250	CDD:320041	11/28 (39%)
		EF-hand motif	267..300	CDD:320041	19/32 (59%)
		PLN02228	285..819	CDD:177873	359/534 (67%)
		PI-PLCc_beta	312..680	CDD:176533	231/368 (63%)
		DUF1154	922..966	CDD:461969	19/43 (44%)
		PLC-beta_C	1023..1168	CDD:462571	43/148 (29%)