DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NO66 and riox2

DIOPT Version :9

Sequence 1:	NP_572160.1	Gene:	NO66 / 31374	FlyBaseID:	FBgn0266570	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_956631.1	Gene:	riox2 / 393308	ZFINID:	ZDB-GENE-040426-1283	Length:	528	Species:	Danio rerio

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	209/527 - (39%)	Gaps:	111/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 GNNNNDEKETETIETHKADSVEEGRRVLQWILFPVQTKVFFKDFWEHTACLVQRSNPK---YFQS 251
            |:....|:|..........|....:...|.::.|:..:.||:.|||....::.||:..   |:.|
Zfish    33 GSPQEIEQEERLQRVSTLSSSGSPQEFFQSLIRPLDLQEFFQRFWERQPLVLHRSDAALAGYYGS 97

  Fly   252 MISFKMLDEILIRHHLDFTVNVDVTTYKNGKRETLNPEGRALPPAV------WGFYSDGCSIRLL 310
            :.....|..:..| .|.:..:::......|::..||..|     ||      ..|.....:|:..
Zfish    98 LFPLSGLRRLCAR-GLQYGTDINTCRCVRGQKRLLNRAG-----AVDFCLLERDFLEKKATIQFH 156

  Fly   311 NPSTYLIRLRQVCTVLQEFFHCKVGANLYLTPPNSQGFAPHYDDIEAFVIQVEGRKRWLLYEPPK 375
            .|..:...|.::...|:.||.|.||:|:|:||..:||..|||||:|..::|:||:|.|.||||
Zfish   157 QPQRFQDELWRIQERLECFFGCLVGSNVYITPAGAQGLPPHYDDVEVLILQLEGQKHWRLYEP-- 219

  Fly   376 KADQLARISSGNYDQE---QLGKPIIDEVLSAGDVLYFPRGAVHQAITEE-QQHSLHITLSVYQQ 436
             ...|||    .|..|   ::|.|..|.:|.|||:||||||.:|||.|.. ..||.|:|||.||.
Zfish   220 -TVPLAR----EYSLEPEGRIGAPTHDFILQAGDLLYFPRGTIHQADTPAGAGHSTHLTLSTYQN 279

  Fly   437 Q---AYANLLETLMPMVLKKAVDRSVALRRGLPLHTFQVLGNAYKG------------------N 480
            .   |..|:..|           .:..|:..|.||:|.|...|.:.                  .
Zfish   280 MCVCAVHNVTHT-----------HTHTLQNVLVLHSFIVCVRACRSWGDLLLDLMPGCVFDRMKT 333

  Fly   481 DCGSRKQLVENVQKLVTNYLMPSEDD--------IDEAVDQ---------MAKKFQHEALPPIVL 528
            ||..|..|...:  |.|..:.|:...        :.:.|||         |.:.|....|||.:.
Zfish   334 DCELRTGLPRGL--LTTPSISPAVSHQLSVFLRRLADVVDQQGQSLRSSSMRRDFISHRLPPFLQ 396

  Fly   529 PSEEVRTVHGARSDADEQGNCVCDYKFNKKTSVRLLRANILRLVTE-----SDGSVRIYHHVDNG 588
            ..:.::.|.||.:..|               :|.|...:.|.|..|     :|.:..:..:|.:.
Zfish   397 DPQLLQPVGGAPALQD---------------TVSLRFKDHLLLTVEPSPDHTDEATELLVYVLHS 446

  Fly   589 LDYCKYEPYFMEILPEEAKAVELLISAYPF----------YLTIDQLPLE----SSARKIEVATA 639
            |...:.....|....|:....|..:....|          .|..|::|:|    ....|:.:..|
Zfish   447 LRNRRDTHMMMGASDEDEDDEESQVGGLRFPLSHLEALQQLLVSDRVPVEDLQLQQEDKLNLLLA 511

  Fly   640 LWEHGLL 646
            ||..|||
Zfish   512 LWSEGLL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NO66	NP_572160.1	cupin_like	229..534	CDD:304367	104/355 (29%)
riox2	NP_956631.1	Cupin_4	70..397	CDD:285279	104/352 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3706
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256684at33208
OrthoFinder	1	1.000	-	-		FOG0003095
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2682
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.780