Protein Alignment mei-9 and RAD1

DIOPT Version :10

• Sequence 1: NP_525068.1
• Gene: mei-9 / 31373
• FlyBaseID: FBgn0002707
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_015303.1
• Gene: RAD1 / 856085
• SGDID: S000005943
• Length: 1100
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 298/1067 - (27%)
• Similarity: 500/1067 - (46%)
• Gaps: 188/1067 - (17%)

  Fly     8 NAAKGTENERPKEVEASA---DTVPQVEEGVEEYLKRKN----------MVLLDYEKQMFLDLVE 59
            |.....|||..|.::..|   ..:|...:.:|......|          :.|...:|.:...|:.
Yeast    41 NHLNEVENEDSKVLDDDAVLYPLIPNEPDDIETSKPNINDIRPVDIQLTLPLPFQQKVVENSLIT 105

  Fly    60 ADGLLVCAKGLSYDRVVISILKAY----SDSGN----LVLVINSSDWEEQYYKSKIE-------- 108
            .|.|::..|||....:|.::|...    |.:|.    ||||:|:...:....|..:|
Yeast   106 EDALIIMGKGLGLLDIVANLLHVLATPTSINGQLKRALVLVLNAKPIDNVRIKEALEELSWFSNT 170

  Fly   109 ------------------PKYVHEVASTATE-RERVYLEGGLQFISTRILVVDLLKQRIPIELIS 154
                              |..|....|.:.| |.::|:.||:..|::|||:||||...:....::
Yeast   171 GKDDDDTAVESDDELFERPFNVVTADSLSIEKRRKLYISGGILSITSRILIVDLLSGIVHPNRVT 235

  Fly   155 GIIVLRAHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWP 219
            |::||.|.::..:..|:|.|.::|.||..||:||||.:||.|.:.:|.:...|:.|.:|::.:||
Yeast   236 GMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPETFVMEFSPLRTKMKELRLKNVLLWP 300

  Fly   220 RFHESVRTVLQPWKIQS----IEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVE 280
            ||...|.:.|......|    ||:.|.::.:::.||..::|.:...:.|:.|.|..:.::...:|
Yeast   301 RFRVEVSSCLNATNKTSHNKVIEVKVSLTNSMSQIQFGLMECLKKCIAELSRKNPELALDWWNME 365

  Fly   281 NCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFM-------KRY 338
            |.:..:|.:.:.:.:...||:::.::|.:|.|::.||.|:...:..|||..:..:       |..
Yeast   366 NVLDINFIRSIDSVMVPNWHRISYESKQLVKDIRFLRHLLKMLVTSDAVDFFGEIQLSLDANKPS 430

  Fly   339 RSTEYALSNSGWTLLDAAEQIFKLSRQRVFNGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRS 403
            .|.:|  |.|.|.|:|.|:.:...:::|:|. :.|:..|..|||:.|..:|     .|:...|.:
Yeast   431 VSRKY--SESPWLLVDEAQLVISYAKKRIFY-KNEYTLEENPKWEQLIHIL-----HDISHERMT 487

  Fly   404 EQ-QPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKL---------SDNYAKESQT 458
            .. |...|:.|.|..||.:|.:.|.....:..::|.|     :.||         :....||.|:
Yeast   488 NHLQGPTLVACSDNLTCLELAKVLNASNKKRGVRQVL-----LNKLKWYRKQREETKKLVKEVQS 547

  Fly   459 RSAPPKNVSSN--KELRREEVSGSQPPLAGMDELAQLLSESETEGQH------FEESYMLTMTQP 515
            :...|:|.:.|  ....:|:|:..:....|..::| .:.:....|.:      ||:.   .:::.
Yeast   548 QDTFPENATLNVSSTFSKEQVTTKRRRTRGASQVA-AVEKLRNAGTNVDMEVVFEDH---KLSEE 608

  Fly   516 VEVGP-----------AAIDIK-------------PDPDVSI----FETIPELEQF-------DV 545
            ::.|.           ||.|.|             .|.|...    .|.:.:|.|.       |:
Yeast   609 IKKGSGDDLDDGQEENAANDSKIFEIQEQENEILIDDGDAEFDNGELEYVGDLPQHITTHFNKDL 673

  Fly   546 TAALAS----VPHQPYICLQTFKTEREGSMALEHMLEQLQPHYVVMYNMNVTAIRQLEVFEA-RR 605
            .|...:    |..|..|.:.|||:..:..     .|:::.|.|::|:..:::.|||:||::| .:
Yeast   674 WAEHCNEYEYVDRQDEILISTFKSLNDNC-----SLQEMMPSYIIMFEPDISFIRQIEVYKAIVK 733

  Fly   606 RLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTY 670
            .|.|    ||||:.:..::|||::||:::|||.||..:|...:.:    ....:|:|.....|..
Yeast   734 DLQP----KVYFMYYGESIEEQSHLTAIKREKDAFTKLIRENANL----SHHFETNEDLSHYKNL 790

  Fly   671 DDEPTD----ENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYI 731
            .:....    ..:.:|.||||..........||||.|||.:.||.|:::.|:.|:|..:|:|||:
Yeast   791 AERKLKLSKLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVGDYV 855

  Fly   732 LTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKFMLSQQTSMA 796
            :|||||:||||||||||||.:.||.|||.:|.::||.|.||||||:.:.|.|:   ..|::.:..
Yeast   856 ITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLE---PFSERRNYK 917

  Fly   797 NADI--------------VQ-KLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAA 846
            |.||              :| ||..|.|.||.|::|||.||..|..:..|||||:.:|||..|..
Yeast   918 NKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGREQPDPSNAVI 982

  Fly   847 LGSDEPTAGEQLHFNS---GIYD--------FLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKEL 900
            ||:::..:    .|||   |:.|        .||.:|||...:...|.:|..|..:|...|..|:
Yeast   983 LGTNKVRS----DFNSTAKGLKDGDNESKFKRLLNVPGVSKIDYFNLRKKIKSFNKLQKLSWNEI 1043

  Fly   901 EELLQSQESAKLLYDILHVAHLPEKDE 927
            .||:..::....:|..|..    ||:|
Yeast  1044 NELINDEDLTDRIYYFLRT----EKEE 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_525068.1	rad1	122..923	CDD:273163	263/899 (29%)
RAD1	NP_015303.1	rad1	203..1066	CDD:273163	265/903 (29%)