DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-9 and MUS81

DIOPT Version :9

Sequence 1:	NP_001284859.1	Gene:	mei-9 / 31373	FlyBaseID:	FBgn0002707	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001337212.1	Gene:	MUS81 / 80198	HGNCID:	29814	Length:	552	Species:	Homo sapiens

Alignment Length:	655	Identity:	131/655 - (20%)
Similarity:	201/655 - (30%)	Gaps:	264/655 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 KLSRQRVFNGQQEFEPEP-CP-----KWQTLTDLLTKEIPGDMRRSR-----------------R 402
            :|.|:|         |.| ||     :|  ||: ...|.....||:|                 |
Human     6 RLGRKR---------PLPACPNPLFVRW--LTE-WRDEATRSRRRTRFVFQKALRSLRRYPLPLR 58

  Fly   403 SEQQPKVLI-----LCQ--DARTCHQLKQYLTQGGPRFLLQQALQHE-VPVGKLSDNYAKESQTR 459
            |.::.|:|.     ||:  |.|    |:::.|.||.......:.::. .|.|:|:     |.|..
Human    59 SGKEAKILQHFGDGLCRMLDER----LQRHRTSGGDHAPDSPSGENSPAPQGRLA-----EVQDS 114

  Fly   460 SAP----PKNVSSNKELRREEVSGSQPPLAGMDELAQLL----SESETEGQHF---EESYMLTMT 513
            |.|    ||...          |||..|.........||    ......|.||   ||.......
Human   115 SMPVPAQPKAGG----------SGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQ 169

  Fly   514 QPVEVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTER-----EGSMAL 573
            :...|.|.:  .:|.|                  ||.|:.|:..: |:|.:..|     ||   |
Human   170 KSPRVAPGS--ARPWP------------------ALRSLLHRNLV-LRTHQPARYSLTPEG---L 210

  Fly   574 EHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEE---QAYLTSLRR 635
            |...:..:...:.:.|:.:..           :.||.:...|.....|....|   |.....||.
Human   211 ELAQKLAESEGLSLLNVGIGP-----------KEPPGEETAVPGAASAELASEAGVQQQPLELRP 264

  Fly   636 EKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIV 700
            .:......:|.           |:|                      :.||..|:..:|
Human   265 GEYRVLLCVDI-----------GET----------------------RGGGHRPELLRE------ 290

  Fly   701 DMREFRSDLPCLIHKRGLEVLPLTIT-----IGDYI-----------------LTPDICVERKSI 743
                             |:.|.:|.|     :||::                 |..|..||||.:
Human   291 -----------------LQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRL 338

  Fly   744 SDLIGSLNSGRLYNQCVQMQR-HYAKPILLIEFDQNKPFH---LQGKFMLSQQTS---------M 795
            .||..|:..||...|..:::| ...:.:.|:|  ::...|   |....:|...|:         .
Human   339 DDLCSSIIDGRFREQKFRLKRCGLERRVYLVE--EHGSVHNLSLPESTLLQAVTNTQVIDGFFVK 401

  Fly   796 ANADIVQKLQLLTLHFPKLRLIWS-----PSPYATAQLFEELKLGKPE------PDPQTAAALGS 849
            ..|||.:....|.|....|:.::.     ..|:.|.        |.||      |:|..:....|
Human   402 RTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTP--------GNPESGAMTSPNPLCSLLTFS 458

  Fly   850 DEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQ----SQESA 910
            |         ||:|                 .:..|..|:|::..|      :|:|    |.|.|
Human   459 D---------FNAG-----------------AIKNKAQSVREVFAR------QLMQVRGVSGEKA 491

  Fly   911 KLLYD 915
            ..|.|
Human   492 AALVD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_001284859.1	rad1	122..923	CDD:273163	131/655 (20%)
mei-9	NP_001284859.1	ERCC4	700..832	CDD:280828	33/171 (19%)
MUS81	NP_001337212.1	HHH_8	<43..79	CDD:317159	6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..130		14/60 (23%)
		Interaction with BLM. /evidence=ECO:0000269\|PubMed:15805243	125..244		30/163 (18%)
		ERCC4	273..416	CDD:308387	36/200 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900