DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-9 and Ercc4

DIOPT Version :9

Sequence 1:	NP_001284859.1	Gene:	mei-9 / 31373	FlyBaseID:	FBgn0002707	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_038942942.1	Gene:	Ercc4 / 304719	RGDID:	1560340	Length:	917	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	379/945 - (40%)
Similarity:	565/945 - (59%)	Gaps:	109/945 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KRKNMV-LLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYY 103
            :|::|. ||:||:|..|:|:::|||:|||:||..||::...|:.:.....||||:|:...||:|:
  Rat     8 ERQSMAPLLEYERQQVLELLDSDGLVVCARGLGADRLLYHFLRLHCHPACLVLVLNTQPAEEEYF 72

  Fly   104 --KSKIE-----PKYV-HEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLR 160
              :.|||     |:.| :|:||.:  |..||.:||:.|.::||||||.|..|||.:||:||:|.|
  Rat    73 INQLKIEGVEHLPRRVTNEIASNS--RYEVYTQGGIIFATSRILVVDFLTGRIPSDLITGILVYR 135

  Fly   161 AHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESV 225
            ||.|||||||||.|||||||||.||:|||:.:..||..|:.||||.|||||||.||:|||||.:|
  Rat   136 AHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVKKLYLWPRFHVAV 200

  Fly   226 RTVLQPWKIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKI 290
            .:.|:..|.:.:|:||.::..:.:||:.||:::|..::|:|..|.::::|.:::||.:.|.|.|.
  Rat   201 NSFLEQHKPEVVEIHVSMTPAMLAIQTAILDVLNACLKELKYHNPSLEVEDLSLENALGKPFDKT 265

  Fly   291 LQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYAL-SNSGWTLLD 354
            ::..||.:||||.::||.:|.||||||:|:.....:|.|:....::..|:||... .||||..||
  Rat   266 IRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLD 330

  Fly   355 AAEQIFKLSRQRVFN-----------------GQQEFEP------EPCPKWQTLTDLLTKEIPGD 396
            |:..:|..:|.||:.                 |.:|.|.      |..|||:.||::| |||..:
  Rat   331 ASTSMFVNARARVYRVPDVKLSKKTKTSEKMAGPEEQETKKELVLESNPKWEALTEVL-KEIETE 394

  Fly   397 MRRSRRSEQQPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKL------------- 448
            .:.|.......:|||...|.|||.||:.|||.|...|||:...:.....||.
  Rat   395 NKESEALGGPGQVLICASDDRTCCQLRDYLTAGAEAFLLRLYRKTFEKDGKAEEVWVNFRKGDGP 459

  Fly   449 -----SDNYAKESQTRSAPPKNVSSNKELRREEVSGSQPPLAGMDELAQLLSESE---TEGQHFE 505
                 ||...|::|.:........:.|..::.|::           |.|:|..:|   .||...|
  Rat   460 KRTMKSDKRPKDAQNKERASTKRGALKRKKKRELT-----------LTQVLGTAEEPPEEGAVEE 513

  Fly   506 ESYMLTMTQPV----EVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTE 566
            :.:..|.:.|.    |:...:.|:....|.:          :.:.....::.|....|...:
  Rat   514 DLHKQTGSSPEVCGGEIQHESFDLNVSSDAA----------YGILKEPLTIIHPLLGCSDPY--- 565

  Fly   567 REGSMALEHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLT 631
                 ||..:|.:::|.|||:|:..:|.:||||::.|.|   |...::|||.::..:.|||.|||
  Rat   566 -----ALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASR---PGKPLRVYFFVYGGSTEEQRYLT 622

  Fly   632 SLRREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLL---KTYDDEPTDENAKSRQAGGQAPQATK 693
            :||:||.|||.:|..|:.||:|:.::|: ||..|.|   ....|.|||    :|:||||....|:
  Rat   623 ALRKEKEAFEKLIREKASMVVPEEREGR-DETNLDLARGTAAMDTPTD----TRKAGGQERNGTQ 682

  Fly   694 ETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQ 758
              |.::||||||||:||.|||:||:::.|:|:.:|||||||::||||||:|||||||:|||||:|
  Rat   683 --PSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQ 745

  Fly   759 CVQMQRHYAKPILLIEFDQNKPFHL--QGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPS 821
            |:.|.|:|.:|:||||||.:|||.|  :|.|:    ..|:::|:..||.|||||||:|||:|.||
  Rat   746 CLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFV----QEMSSSDVSSKLTLLTLHFPRLRLLWCPS 806

  Fly   822 PYATAQLFEELKLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKG 886
            |:|||:||||||..||:||..||.|:.:|..|..|...:|.|..||:|::|||:.:|...|:.:.
  Rat   807 PHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKMPGVNAKNCRSLMNQV 871

  Fly   887 GSLRQLLLRSQKELEELLQSQESAKLLYDILHVAH 921
            .::.:|...|.:.|..:|....:||.|:|.||.|:
  Rat   872 QNIAELATLSLERLTGILGHSGNAKQLHDFLHTAY 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_001284859.1	rad1	122..923	CDD:273163	343/854 (40%)
mei-9	NP_001284859.1	ERCC4	700..832	CDD:280828	84/133 (63%)
Ercc4	XP_038942942.1	DEAD-like_helicase_N	21..165	CDD:421690	76/145 (52%)
Ercc4	XP_038942942.1	rad1	97..908	CDD:273163	343/854 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3836
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188827at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010