Protein Alignment mei-9 and ERCC4

DIOPT Version :10

• Sequence 1: NP_525068.1
• Gene: mei-9 / 31373
• FlyBaseID: FBgn0002707
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_011520726.1
• Gene: ERCC4 / 2072
• HGNCID: 3436
• Length: 962
• Species: Homo sapiens
• Alignment Length: 978
• Identity: 380/978 - (38%)
• Similarity: 565/978 - (57%)
• Gaps: 145/978 - (14%)

  Fly    46 LLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYY--KSKIE 108
            ||:||:|:.|:|::.|||:|||:||..||::...|:.:.....||||:|:...||:|:  :.|||
Human    15 LLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVLVLNTQPAEEEYFINQLKIE 79

  Fly   109 -----PKYV-HEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELIS------------- 154
                 |:.| :|:  |:..|..||.:||:.|.::||||||.|..|||.:||:
Human    80 GVEHLPRRVTNEI--TSNSRYEVYTQGGVIFATSRILVVDFLTDRIPSDLITEILPLTCQKHPTP 142

  Fly   155 ---------------------------------GIIVLRAHTIIESCQEAFALRLFRQKNKTGFV 186
                                             ||:|.|||.|||||||||.|||||||||.||:
Human   143 GPVPSLSPQPGSLELSWPRWSQGSIQPLFRYHLGILVYRAHRIIESCQEAFILRLFRQKNKRGFI 207

  Fly   187 KAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPWKIQSIEMHVPISQNITSIQ 251
            |||:.:..||..|:.||||.||||||:.||:|||||.:|.:.|:..|.:.:|:||.::..:.:||
Human   208 KAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQ 272

  Fly   252 SHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKIL 316
            :.||:|:|..::|:|..|.::::|.:::||.:.|.|.|.::..||.:||||.::||.:|.|||||
Human   273 TAILDILNACLKELKCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKIL 337

  Fly   317 RSLMISTMYHDAVSAYAFMKRYRSTEYAL-SNSGWTLLDAAEQIFKLSRQRVFN----------- 369
            |:|:.....:|.|:....::..|:||.|. .||||..||::..:|..:|.||::
Human   338 RTLLQYLSQYDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEK 402

  Fly   370 ---------GQQ---EFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQPKVLILCQDARTCHQL 422
                     |::   |...|..|||:.||::| |||..:.:.|.......:|||...|.|||.||
Human   403 ISEKMEIKEGEETKKELVLESNPKWEALTEVL-KEIEAENKESEALGGPGQVLICASDDRTCSQL 466

  Fly   423 KQYLTQGGPRFLL---QQALQHEVPVGKLSDNYAKE--------SQTRSAPPKNV--SSNKE--L 472
            :.|:|.|...|||   ::..:.:....::...:.||        |..|...|:|.  :|.||  |
Human   467 RDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERASTKERTL 531

  Fly   473 RREEVSGSQPPLAGMDELAQLLSESETEGQHFEESYMLTMTQPVEVGPAAIDIKPDPDVSIFETI 537
            ::::...:...:.|..|      |.|.||. .||.|...::...|..|..|
Human   532 KKKKRKLTLTQMVGKPE------ELEEEGD-VEEGYRREISSSPESCPEEI-------------- 575

  Fly   538 PELEQFDVT----AALA------SVPHQPYICLQTFKTEREGSMALEHMLEQLQPHYVVMYNMNV 592
             :.|:|||.    ||..      ::.|....|...:        ||..:|.:::|.|||:|:..:
Human   576 -KHEEFDVNLSSDAAFGILKEPLTIIHPLLGCSDPY--------ALTRVLHEVEPRYVVLYDAEL 631

  Fly   593 TAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIPKYQD 657
            |.:||||::.|.|   |...::|||||:..:.|||.|||:||:||.|||.:|..|:.||:|:.::
Human   632 TFVRQLEIYRASR---PGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEERE 693

  Fly   658 GKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLIHKRGLEVLP 722
            |:.:....|::  .....|.:..:|:||||....|:::  ::||||||||:||.|||:||:::.|
Human   694 GRDETNLDLVR--GTASADVSTDTRKAGGQEQNGTQQS--IVVDMREFRSELPSLIHRRGIDIEP 754

  Fly   723 LTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKF 787
            :|:.:|||||||::|||||||||||||||:||||:||:.|.|:|.:|:||||||.:|||.|..:.
Human   755 VTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRG 819

  Fly   788 MLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALGSDEP 852
            .|.|:.|  :.||..||.|||||||:||::|.|||:|||:||||||..||:||..||.|:.:|..
Human   820 ALFQEIS--SNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSE 882

  Fly   853 TAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQSQESAKLLYDIL 917
            |..|...:|.|..||||::|||:.:|...|:....::.:|...||.||..:|.:..:||.|||.:
Human   883 TLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDFI 947

  Fly   918 HVA 920
            |.:
Human   948 HTS 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_525068.1	rad1	122..923	CDD:273163	347/894 (39%)
ERCC4	XP_011520726.1	rad1	97..953	CDD:273163	347/894 (39%)