DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-9 and Fancm

DIOPT Version :9

Sequence 1:	NP_001284859.1	Gene:	mei-9 / 31373	FlyBaseID:	FBgn0002707	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_849243.2	Gene:	Fancm / 104806	MGIID:	2442306	Length:	2021	Species:	Mus musculus

Alignment Length:	772	Identity:	144/772 - (18%)
Similarity:	261/772 - (33%)	Gaps:	254/772 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 YHDAVSAYAFMKRYRST----EYALSNSGWTLL--------DAAEQIFKL--------------- 362
            :|.| |:....:|.|||    .:|.|.:|..:|        .|..|.||:
Mouse  1293 FHVA-SSSPVKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEE 1356

  Fly   363 --SRQRVFNGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQPKVLILCQDART------C 419
              |..:||..|.       |: :|..:.||.|...|:...:..:.:..||...:|.:.      .
Mouse  1357 TKSSDQVFVHQS-------PR-RTEVEHLTSESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPI 1413

  Fly   420 HQLKQYLTQGGPRFLLQQALQHEVPVGKLSDNYAK--------ESQTR-----SAPPKNVSSNKE 471
            |.:|:      ||.|..:....:    ..|:|:.:        :.:.|     ||..||.|..|.
Mouse  1414 HAVKK------PRVLRSELASSD----DESENFGRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKT 1468

  Fly   472 LRRE------EVSGSQPPLAGMDE---------------------LAQLLSESETEGQHFEESYM 509
            :.|.      ||||........||                     |:|.:::||     ....||
Mouse  1469 MARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLSQAINDSE-----MRAIYM 1528

  Fly   510 LTMTQPVEVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALE 574
            .::..|:......:..:..|:::||..|||.:             :.|: ..:|..:.|.|...:
Mouse  1529 KSVRSPLMSTKYRMVREKRPNMNIFSQIPEQD-------------ENYL-EDSFCVDEEESCKSQ 1579

  Fly   575 HMLEQLQP--------------HYVVMYNMNVTAIRQLEVFEARRR------LP----------P 609
            ...|::..              .|...|.:.:..:.:.:.:...|:      ||          |
Mouse  1580 SSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIP 1644

  Fly   610 ADRMKVYFLIHA----------------------RTVEEQAYLTSLRREKAAFEFIIDTKSKMVI 652
            .||.......||                      :.:.:.::..|.|:.......|.|...:.:.
Mouse  1645 KDREHSVAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLN 1709

  Fly   653 PKYQD-GKTDEA------FLLLKTYDDEPTDENAKSRQ-----------------AGGQAPQATK 693
            .|.|. .|...|      ....|.|.:.|....|.|::                 .|..||:..:
Mouse  1710 VKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQ 1774

  Fly   694 ETPK--VIVDMREFRSDLPCL-----IHKRGLEVLPLTITIG-DYILTPDICVERKSISDLIGSL 750
            |..:  ::||.||..:.|..:     :|...:|:.||.   | |||::..:.|.|:|.|:::.:.
Mouse  1775 EGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLN---GCDYIVSSRMVVVRRSQSEMLSNT 1836

  Fly   751 NSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKFML-----SQQTSMANADIVQKLQLLTLH 810
            :..:...|..::|..:.:..:::|.|:.|......||..     |..|::..|.|
Mouse  1837 SKNKFIEQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGI---------- 1891

  Fly   811 FPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIY---------- 865
                |:::|.....||.|.:||.|.:...                     |:||:
Mouse  1892 ----RILFSSGQEETADLLKELSLVEQRK---------------------NAGIHIPAVLNTSKL 1931

  Fly   866 ---DFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQ-SQESAKLLYDILH 918
               .|.|.:||:.......:..:..|::::...|.:|:....| :.:.|:.:|..:|
Mouse  1932 EALPFYLSIPGISYITALNMCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIH 1988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_001284859.1	rad1	122..923	CDD:273163	144/772 (19%)
mei-9	NP_001284859.1	ERCC4	700..832	CDD:280828	33/142 (23%)
Fancm	NP_849243.2	MPH1	71..610	CDD:224036
		DEXDc	94..236	CDD:238005
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	202..205
		FANCM_ID	287..401	CDD:277190
		Helicase_C	457..564	CDD:278689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657
		FANCM-MHF_bd	657..769	CDD:293388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..886
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1273
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1319		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1369..1441		16/82 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1447..1466		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1615..1700		10/84 (12%)
		Interaction with FAAP24. /evidence=ECO:0000250\|UniProtKB:Q8IYD8	1689..2009		67/338 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1732		3/19 (16%)
		MUS81	1764..1999	CDD:224859	54/263 (21%)
		ERCC4	1783..1909	CDD:280828	33/142 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900