DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-9 and Ercc4l1

DIOPT Version :9

Sequence 1:	NP_001284859.1	Gene:	mei-9 / 31373	FlyBaseID:	FBgn0002707	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_038943512.1	Gene:	Ercc4l1 / 103693257	RGDID:	1304845	Length:	881	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	348/934 - (37%)
Similarity:	535/934 - (57%)	Gaps:	123/934 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KRKNMV-LLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYY 103
            :|::|. ||:||:|..|:|:::|||:|||:||..||::...|:.:.....||||:|:...||:|:
  Rat     8 ERQSMAPLLEYERQQVLELLDSDGLVVCARGLGADRLLYLFLRLHCHPACLVLVLNTQPAEEEYF 72

  Fly   104 KSKIEPKYVHEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIESC 168
            .::::           ||        |::.:..:           .::.::.|:|.|||.|||||
  Rat    73 INQLK-----------TE--------GVKHLKVK-----------NVKYLNCILVYRAHRIIESC 107

  Fly   169 QEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPWK 233
            ||||.|||||||||.||:|||:.:..||..|:.||||.|||||:|.||:|||||.:|.:.|:..|
  Rat   108 QEAFILRLFRQKNKLGFIKAFTDNAVAFDTGFCHVERVMRNLFMKKLYLWPRFHVAVNSFLEQHK 172

  Fly   234 IQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDCI 298
            .:.:|:.|.::..:.:||:.||:::|..::|:|..|.::::|.:::||.:.|.|.|.:...||.:
  Rat   173 PEVVEIRVSMTLAMLAIQTAILDVLNACLKELKYHNLSLEVEDLSLENALGKPFDKTICHYLDPL 237

  Fly   299 WHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYAL-SNSGWTLLDAAEQIFKL 362
            ||||.::||.:|.||||||:|:.....:|.|:....::..|:||... .||||..|||:..:|..
  Rat   238 WHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLDASTSMFVN 302

  Fly   363 SRQRVFN-----------------GQQEFEP------EPCPKWQTLTDLLTKEIPGDMRRSRRSE 404
            :|.||:.                 |.:|.|.      |..|||:.||::| |||..:.:.|....
  Rat   303 ARARVYRVPDVKLSKKTKTSEKMAGPEEQETKKELVLESNPKWEALTEVL-KEIETENKESEALG 366

  Fly   405 QQPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKL------------------SDN 451
            ...:|||...|.|||.||:.|||.|...|||:...:.....||.                  ||.
  Rat   367 GPGQVLICASDDRTCCQLRDYLTAGAEAFLLRLYRKTFEKDGKAEEVWVNFRKGDGPKRTMKSDK 431

  Fly   452 YAKESQTRSAPPKNVSSNKELRREEVSGSQPPLAGMDELAQLLSESE---TEGQHFEESYMLTMT 513
            ..|::|.:........:.|..::.|::           |.|:|..:|   .||...|:.:..|.:
  Rat   432 RPKDAQNKERASTKRGALKRKKKRELT-----------LTQVLGTAEEPPEEGAVEEDLHKQTGS 485

  Fly   514 QPV----EVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALE 574
            .|.    |:...:.|:....|.:          :.:.....::.|....|...:        ||.
  Rat   486 SPEVCGGEIQHESFDLNVSSDAA----------YGILKEPLTIIHPLLGCSDPY--------ALT 532

  Fly   575 HMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAA 639
            .:|.:::|.|||:|:..:|.:||||::.|.|   |...::|||.::..:.|||.|||:|.:||.|
  Rat   533 RVLHEVEPRYVVLYDAELTFVRQLEIYRASR---PGKPLRVYFFVYGGSTEEQRYLTALCKEKEA 594

  Fly   640 FEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMRE 704
            ||.:|..|:.||:|:.::|: ||..|.| .......|.:..:|:||||....|:  |.::|||||
  Rat   595 FEKLIREKASMVVPEEREGR-DETNLDL-ARGTAAMDTSTDTRKAGGQERNGTQ--PSIVVDMRE 655

  Fly   705 FRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKP 769
            |||:||.|||:||:::.|:|:.:|||||||::||||||:|||||||:|||||:||:.|.|:|.:|
  Rat   656 FRSELPSLIHRRGIDIEPVTLKVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYRRP 720

  Fly   770 ILLIEFDQNKPFHL--QGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEEL 832
            :||||||.:|||.|  :|.|:    ..|:::|:..||.|||||||:|||:|.|||:|||:|||||
  Rat   721 VLLIEFDPSKPFSLAPRGAFV----QEMSSSDVSSKLTLLTLHFPRLRLLWCPSPHATAELFEEL 781

  Fly   833 KLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQ 897
            |..||:||..||.|:..|..|..|...:|.|..||:.::|||:.:|...|:.:..::.:|...|.
  Rat   782 KQNKPQPDAATAMAITEDSETLPESDRYNPGPQDFVQKMPGVNAKNCRSLMNQVQNIAELATLSL 846

  Fly   898 KELEELLQSQESAKLLYDILHVAH 921
            :.|..:|....:||.|:|.||.|:
  Rat   847 ERLTGILGHSGNAKQLHDFLHTAY 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_001284859.1	rad1	122..923	CDD:273163	318/851 (37%)
mei-9	NP_001284859.1	ERCC4	700..832	CDD:280828	84/133 (63%)
Ercc4l1	XP_038943512.1	rad1	95..872	CDD:273163	317/817 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188827at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010