DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-9 and ercc4

DIOPT Version :9

Sequence 1:	NP_001284859.1	Gene:	mei-9 / 31373	FlyBaseID:	FBgn0002707	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_002935520.3	Gene:	ercc4 / 100145552	XenbaseID:	XB-GENE-986815	Length:	893	Species:	Xenopus tropicalis

Alignment Length:	923	Identity:	380/923 - (41%)
Similarity:	562/923 - (60%)	Gaps:	91/923 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYYKSKIE-- 108
            ||::|.|:||||...|||::.|:||..||::.:.||.|.|.||||||:|::..||:|...::.
Frog     4 LLEHENQVFLDLFHEDGLVITARGLGIDRILQNFLKLYCDPGNLVLVLNTNTAEEEYLIDQLRSE 68

  Fly   109 -----PKYV-HEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIES 167
                 |:.: :|||:  .||..||.:||:.|:::||||||.|..|||..||:||:|.:||.||||
Frog    69 GVTHLPRIITNEVAT--GERYDVYTQGGVLFVTSRILVVDFLTDRIPANLITGILVYKAHKIIES 131

  Fly   168 CQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPW 232
            |||||.|||:|||||.||:|||:.:|.||..|:..|||.|||||||.||:|||||.||.:.|...
Frog   132 CQEAFILRLYRQKNKQGFIKAFTDNPVAFHTGFCQVERVMRNLFVKKLYLWPRFHVSVNSFLDKH 196

  Fly   233 KIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDC 297
            |.:.:|:||.::..:.:|||.||:|||..::|:||.|..:::|.:::||.:.|:|.|.::..||.
Frog   197 KPEVVELHVSMTPAMLAIQSSILDIMNACLKELKRYNPALEVEDLSLENAIGKAFDKTIRHYLDP 261

  Fly   298 IWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYAL-SNSGWTLLDAAEQIFK 361
            :||||.::||.:|.||||||:|:.....:|.|:....::..:::|.|. .||||..||::..:|.
Frog   262 LWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESMKASEKAFGQNSGWLFLDSSTSMFV 326

  Fly   362 LSRQRVF--------------------NGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQ 406
            .:|.||:                    :|::|...|..|||:.|:::| |||..:.:.|......
Frog   327 HARARVYHVPDSKAIKKSKQSDSNEKQDGKKELVLENNPKWEALSEVL-KEIEQENKNSEALGGP 390

  Fly   407 PKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVG---KLSDNYAKESQTRSAPPKNVSS 468
            .:|||...|.|||.||::|:..|....|  :.|.::. .|   |.|:.:.|..:..:|...|.|.
Frog   391 GRVLICASDDRTCAQLREYIAVGAEALL--ERLYNKT-FGKDEKASEVWMKRRKAITAKGSNKSM 452

  Fly   469 NKELRREEVSGSQPPLAGMDELAQLLSESETEGQHFEESYMLTMTQPV------EVGPAAIDIKP 527
            ...|.::...|..         .|..:.::||         ||:||.:      |||..  |::.
Frog   453 KTSLPKKPKEGKS---------KQKKNNTKTE---------LTLTQMIGKEEEDEVGKD--DVES 497

  Fly   528 DPDVSIFE---------TIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALEHMLEQLQPH 583
            ....|.||         .:|....:.:.....:|.|....|        ..|..|..:|.:::|.
Frog   498 VSQESSFEEPKYEDLQLNLPSDSYYGILKEPLTVIHPLQGC--------SDSYGLTRVLHEIEPR 554

  Fly   584 YVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKS 648
            |||:|:..::.:||||::.|.::.|    ::|||||:..:.|||.||||||:||.|||.:|..|:
Frog   555 YVVLYDSELSFVRQLEIYRASKQKP----LRVYFLIYGGSTEEQRYLTSLRKEKEAFEQLIREKA 615

  Fly   649 KMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLI 713
            .||||:.:||:.|....|.:  |...|.::|.:|:||||.....::|  :|||||||||:||.||
Frog   616 SMVIPEERDGRDDTNLDLQR--DVTSTFDSADTRKAGGQVQNNVQQT--IIVDMREFRSELPSLI 676

  Fly   714 HKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQN 778
            |:||:::.|:|:.:|||||||||||||||:||||||||:||||.|||.|.|:|.:|:||||||.|
Frog   677 HRRGIDIEPVTLEVGDYILTPDICVERKSVSDLIGSLNNGRLYTQCVSMCRYYKRPVLLIEFDPN 741

  Fly   779 KPFHLQGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQT 843
            |||.|..|..:.|:.|:  .||..|:.|||||||:||::|.|||||||:||||||..:|:||..|
Frog   742 KPFSLVSKNSIHQEISV--NDITSKIALLTLHFPRLRILWCPSPYATAELFEELKQNRPQPDSAT 804

  Fly   844 AAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQSQE 908
            |.|:.:|..:..|...:|.|..||||::|||:.:|...:::...|:.:|...|.::|.|:|.:..
Frog   805 AMAITADSESLPESEKYNPGPQDFLLKMPGVNAKNCRAIMKHVTSIAELTTLSLEKLTEILGNSN 869

  Fly   909 SAKLLYDILHVAH 921
            :||.||:.:..::
Frog   870 NAKQLYEFMRTSY 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-9	NP_001284859.1	rad1	122..923	CDD:273163	345/839 (41%)
mei-9	NP_001284859.1	ERCC4	700..832	CDD:280828	88/131 (67%)
ercc4	XP_002935520.3	rad1	86..884	CDD:273163	345/839 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3836
Inparanoid	1	1.050	652	1.000	Inparanoid score	I781
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188827at33208
OrthoFinder	1	1.000	-	-		FOG0004122
OrthoInspector	1	1.000	-	-		oto105258
Panther	1	1.100	-	-	LDO	PTHR10150
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2865
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160