DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	928	Identity:	218/928 - (23%)
Similarity:	331/928 - (35%)	Gaps:	192/928 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QRKP--------VGKPLILTC--RPTVPEPSLVADLQWKDNRNNTILP--------KPNGRNQPP 88
            :|||        .|:..:|.|  .|....|.|.. ::|.  |...:||        .|  |..|.
Mouse    21 RRKPEVVSVVGRAGESAVLGCDLLPPAGHPPLHV-IEWL--RFGFLLPIFIQFGLYSP--RIDPD 80

  Fly    89 MYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPE-NQYPTLG 152
            ...........:|.|..|.||..|.|.|...:.:....|:.....::|.:|..:.|: .:.|.|.
Mouse    81 YVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLV 145

  Fly   153 ------QDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAV 211
                  :...:.|..:..|.|.:.|...|..:.....:..||...|.||.|:....|.|||:|:.
Mouse   146 LEVKELEAVTLRCVARGSPQPYVTWKFRGQDLGKGQGQVQVQNGTLWIRRVERGSAGDYTCQASS 210

  Fly   212 IETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVP-EISWIRDATQLNVATA 275
            .| |.:...| ::.|...|.|:..|:|......:..:..|.|...|.. ..||.:|.  :||...
Mouse   211 SE-GSITHAT-QLLVLGPPVIVVPPSNSTVNSSQDVSLACRAEAYPANLTYSWFQDG--VNVFHI 271

  Fly   276 DRFQVNPQ---TGLVTISSVSQDDYGTYTCLAKNRAGVV---DQKTKLNVLVRPQIY----ELYN 330
            .|.|...:   .|.:.:.:...||.|.|||:..|  |.:   .....|.||...|:.    |...
Mouse   272 SRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSN--GFLHPPSASAYLTVLYPAQVTVMPPETPL 334

  Fly   331 VTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRIS 395
            .||.|.   .|.|..  |..|.:.|..|....:..  |.|..|...|.|.         |:|.|:
Mouse   335 PTGMRG---VIRCPV--RANPPLLFVTWTKDGQAL--QLDKFPGWSLGPE---------GSLIIA 383

  Fly   396 NAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQ---------RKANLSC 451
            ....:..|.|.|...|...        |...:|....:.:.||.|..:.         |:..:.|
Mouse   384 LGNENALGEYSCTPYNSLG--------TAGPSPVTQVLLKAPPAFIDQPKEEYFQEVGRELLIPC 440

  Fly   452 LAMGIPNATIEWHWNGRKIKD--LYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAE 514
            .|.|.|...:.|...||.::.  ..|:|         :.|::.|:|::....::|.|:|
Mouse   441 SARGDPPPIVSWAKVGRGLQGQAQVDSN---------NSLVLRPLTKEAQGRWECSASN------ 490

  Fly   515 HDMQLKEARVPD----FVSEAKPSQLTATTMTFDIRGP--STELGLP---ILAYSVQYKE-ALNP 569
                 ..|||..    :|....|..:|..::....:|.  |.|.|..   :..:||.|.. |..|
Mouse   491 -----AVARVTTSTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYTPLAKRP 550

  Fly   570 DWSTAYNRSW-SPDSP-----YIVEGLRPQTEYSFRFAARNQVGLGNW---------GVNQQQST 619
            |.:   :..| |...|     .:|.||:...:|.|...|:|::|.|.:         |:....:.
Mouse   551 DRA---HHDWVSLAVPIGATHLLVPGLQAHAQYQFSVLAQNKLGSGPFSEIVLSIPEGLPTTPAA 612

  Fly   620 PRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWT 684
            |.....|.|.||..|    :....|.:|..  ..|.|..|......:|.|.::   |.:.|..|.
Mouse   613 PGLPPTEIPPPLSPP----RGLVAVRTPRG--VLLHWDPPELIPGRLDGYILE---GRQGSQGWE 668

  Fly   685 ELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAER--Q 747
            .|:......|:    ...:..|:.:..|...|.|......|.|:::...:|.|::|.....:  .
Mouse   669 ILDQGVAGTEI----QLLVPGLIKDVLYEFRLVAFADSYVSDPSNVANISTSGLEVYPSRTQLPG 729

  Fly   748 VFSSAAIVGIAIGGVLLL--LFVVDLLCCITVHMGVMATMCRKAKRS--PSEIDDEAKLGS---- 804
            :.....:.|: :|||..|  ..:|.:|....::....|...||..|.  |.......|.||
Mouse   730 LLPQPVLAGV-VGGVCFLGVAVLVSILAACLMNRRRAARRHRKRLRQDPPLIFSPRGKSGSHSAP 793

  Fly   805 ------------LYGWRFPLPYCSGQLV-KEP--PPSPLPLPPPVKLGGSPMSTPLDEKEPL-RT 853
                        |.|  .|:|.....|: .||  ||||.|..|   ||..|:  ||   ||: |.
Mouse   794 GSGSPDSVTKFKLQG--SPVPSLRQSLLWGEPARPPSPHPDSP---LGRGPL--PL---EPICRG 848

  Fly   854 PTGSIKQNSTIEFDGRFV 871
            |            |||||
Mouse   849 P------------DGRFV 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	25/108 (23%)
		IG_like	144..226	CDD:214653	22/88 (25%)
		IGc2	152..209	CDD:197706	15/62 (24%)
		I-set	230..319	CDD:254352	24/95 (25%)
		IGc2	243..309	CDD:197706	18/69 (26%)
		IG_like	330..424	CDD:214653	21/93 (23%)
		IGc2	339..412	CDD:197706	17/72 (24%)
		Ig	447..518	CDD:143165	15/72 (21%)
		fn3	534..611	CDD:278470	23/88 (26%)
		FN3	640..735	CDD:238020	18/94 (19%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	21/86 (24%)
		Ig	136..223	CDD:386229	22/88 (25%)
		Ig_3	227..305	CDD:372822	21/79 (27%)
		Ig	341..404	CDD:386229	18/83 (22%)
		Ig	436..500	CDD:319273	18/83 (22%)
		FN3	508..599	CDD:238020	24/93 (26%)
		FN3	625..715	CDD:238020	19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842		11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900