DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and IL1RL2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_011510393.1	Gene:	IL1RL2 / 8808	HGNCID:	5999	Length:	622	Species:	Homo sapiens

Alignment Length:	350	Identity:	75/350 - (21%)
Similarity:	122/350 - (34%)	Gaps:	86/350 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALLLCSCSL-IELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTI 77
            :||||..|: :.|:.......:|:.|.|:  ....:|....|  |.| |....::.....:|::.
Human    31 SLLLCGLSIALPLSVTADGCKDIFMKNEI--LSASQPFAFNC--TFP-PITSGEVSVTWYKNSSK 90

  Fly    78 LPKPNGRNQPPMYTETLPGESLALMITSLSVEMG--GKYYCTAS--------YANTEILEKGVTI 132
            :|............||        .|..|.:|.|  |.|.|...        :.|..:.||
Human    91 IPVSKIIQSRIHQDET--------WILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEK---- 143

  Fly   133 KTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPT-------------IDWLRNGDPIRTTNDK 184
                  .|.:......|.|..:|..:..:..|.:.|             |.|.::.:.|:  .::
Human   144 ------HWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIK--GER 200

  Fly   185 YVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQ--------PEIISLPTN--L 239
            :.|....||:.||...|.|.|.|:|.:..:|:..|....:.|.|:        |:|| .|.|  :
Human   201 FTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSIKRAGYGGSVPKII-YPKNHSI 264

  Fly   240 EAVEGKPFAANC------------------TARGKPVPEISWIRDATQLNVATADRFQVNPQTGL 286
            |...|.....:|                  |.......|...||:..:.:|:..:.   |..|..
Human   265 EVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREH---NLYTVN 326

  Fly   287 VTISSVSQDDYG-TYTCLAKNRAGV 310
            :|...|..:||| .:.|    .|||
Human   327 ITFLEVKMEDYGLPFMC----HAGV 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/103 (19%)
		IG_like	144..226	CDD:214653	20/94 (21%)
		IGc2	152..209	CDD:197706	15/69 (22%)
		I-set	230..319	CDD:254352	23/101 (23%)
		IGc2	243..309	CDD:197706	15/84 (18%)
		IG_like	330..424	CDD:214653
		IGc2	339..412	CDD:197706
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
IL1RL2	XP_011510393.1	Ig	54..140	CDD:299845	19/98 (19%)
		Ig2_IL1R_like	158..245	CDD:143234	19/88 (22%)
		IG_like	171..229	CDD:214653	14/59 (24%)
		TIR	413..563	CDD:279864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910