DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and IL1R2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_011510103.1	Gene:	IL1R2 / 7850	HGNCID:	5994	Length:	441	Species:	Homo sapiens

Alignment Length:	244	Identity:	62/244 - (25%)
Similarity:	93/244 - (38%)	Gaps:	40/244 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GKPLILTCRPTVP-------EPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMIT 104
            |:|:.|.| |.||       .|.:  :|.|..|.:...:|   |..:..|:     .:..||.:.
Human    86 GEPVALRC-PQVPYWLWASVSPRI--NLTWHKNDSARTVP---GEEETRMW-----AQDGALWLL 139

  Fly   105 SLSVEMGGKYYCT---ASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMC----EVK 162
            ....|..|.|.||   |||.:...:|..|...|...:.:.:.|  |..||....|::|    |..
Human   140 PALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYP--QILTLSTSGVLVCPDLSEFT 202

  Fly   163 ADPNPT-IDWLRNGDPIRTTNDKY--VVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRV 224
            .|.... |.|.::...:...|:|:  |..|..||:.:|...|.|.|.|.......|:....|..:
Human   203 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSI 267

  Fly   225 EVFIQ-------PEIISLPTNLEAVEGKPFAANC---TARGKPVPEISW 263
            |:.|:       |.|||....:.|..|......|   ...|.|:..:.|
Human   268 ELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLW 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	26/95 (27%)
		IG_like	144..226	CDD:214653	23/88 (26%)
		IGc2	152..209	CDD:197706	17/63 (27%)
		I-set	230..319	CDD:254352	10/37 (27%)
		IGc2	243..309	CDD:197706	5/24 (21%)
		IG_like	330..424	CDD:214653
		IGc2	339..412	CDD:197706
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
IL1R2	XP_011510103.1	PHA02785	49..370	CDD:165149	62/244 (25%)
		Ig1_IL1R_like	73..168	CDD:143233	25/92 (27%)
		Ig2_IL1R2_like	179..273	CDD:143305	25/95 (26%)
		ig	284..384	CDD:278476	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910