DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and zgc:152904

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001070212.1	Gene:	zgc:152904 / 767777	ZFINID:	ZDB-GENE-060929-856	Length:	809	Species:	Danio rerio

Alignment Length:	847	Identity:	230/847 - (27%)
Similarity:	361/847 - (42%)	Gaps:	104/847 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEM 110
            ||:....|| ..:.||   ..:.|...:...|:    ...:..::||   |....|.|.:..:|.
Zfish     3 VGESKFFTC-TAIGEP---VSINWFSPQGERII----SNERVIVHTE---GVRSRLTIYNAIIEN 56

  Fly   111 GGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWL-RN 174
            .|.|.|.|:.|..:..|..|.::.|..:|:......|....|.|..|:|:|.:.|.|.:.|. :|
Zfish    57 AGIYRCQAADAKGQSQEATVVLEIYQKLTFREVKTPQEFRQGDDAEVVCDVISSPVPAVSWFYKN 121

  Fly   175 GDPIRTTNDKY-VVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPT- 237
            .:.....|.:: |:.||.|.|..|.::|||.|.|.|.|...||:..|.|.|:|.: |.::|:|.
Zfish   122 REITSEPNSRFQVLPTNNLQILKVGKADEGAYRCEARVEARGEIDFRDIVVQVNV-PPVLSVPQQ 185

  Fly   238 --NLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTG---LVTISSVSQDDY 297
              |..|...:.....|...|.|.|:::|......  :..::::.:|...|   .:|:.::.|.|.
Zfish   186 SFNATADYQESVTFTCVTSGSPDPQVTWYWKGHA--IEHSEQYVLNTMNGGKSTLTVKNIKQTDG 248

  Fly   298 GTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQE 362
            |.|.|.|.|:||..:.:..|.|.|:|.|.:|.|||........|:|.|:|.|.|.|::||.....
Zfish   249 GPYMCRASNKAGSSESQLFLKVFVQPHITQLRNVTAVEGSAAMISCTAEGEPLPEISWRRASDGH 313

  Fly   363 EYTNGQQDDDPRIILEPNFDEERG-ESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEF 426
            .:|:|::..|.|:       |.|| .....|.||..:.||.|.:.|.|.::.....|:..:.:|:
Zfish   314 SFTDGEKSKDGRV-------EVRGRHGKSMLTISGVQLSDWGRFDCEALSRIGGHQKSMFLDIEY 371

  Fly   427 APDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIV 491
            ||.|...:.:  .:|||....|:||.....|.||:.|......|.....:|::|..|..||.|.|
Zfish   372 APKFQTNQSI--FYSWEGNPVNISCEVKSNPAATMLWRRERFTISSQGTSNIRIHSTDGRSLLEV 434

  Fly   492 HPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPI 556
            .||:.:.:..|.|.|.|..|....:..|.:|.||......:.:.::....|.....|.:..|:||
Zfish   435 TPVSDRDFGRYNCTARNNIGARYQEFILAQADVPSSPYSVRMTAVSQRMATVSFMKPDSHGGVPI 499

  Fly   557 LAYSVQYKEALN-PDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQ-QST 619
            ..|.:.|::..: .:|.:|  |:....:..::..|.|.|.|..|.:|.|..|.|.:...:. |:.
Zfish   500 SFYIINYRDTSSAQEWRSA--RTHGVQTAVVLTSLEPNTTYEVRVSAVNGKGQGEFSHTESFQTL 562

  Fly   620 PRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGV--PADNGEPIDRYQIKYCPGVKISGT 682
            |.|    ||.|   |..|.:..  |...|      |.|:  ..|.|.||..|.:||
Zfish   563 PIR----EPSP---PTVHGQRG--VGKAY------RLGLVKQDDGGMPIVEYILKY--------- 603

  Fly   683 WTELENSCNTVEVMETTSFEMTQ-LVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAER 746
            .|:.|....|..|.....|.:.| |..||.|.:|:.|.|..|.|.|........:..|:..
Zfish   604 KTDKEEQWMTKLVPGMNDFALLQPLQWNTRYNVEITARNVKGLSEPTYFQFLMPQKPDITD---- 664

  Fly   747 QVFSS---AAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRK---AKRSPSEIDDEAKLGSL 805
            .:||.   .|::|:.:..:||||.::|:.|......|::..:.||   .|.|.|....|.:.|.
Zfish   665 SLFSGLGVGAVLGVGVCVLLLLLVLLDVSCFFLRQCGLLMCITRKLCSKKTSTSGKSKELEEGK- 728

  Fly   806 YGWRFPLPYCSGQLV---KEP-------------PPSPLPLPPPVKLGGSPMSTPLDEKEPLRTP 854
                      :..||   |||             |....|:..|.:.  :|::.|  ||.||:..
Zfish   729 ----------AAYLVDGSKEPIVKMRTEEERVTNPEDCSPVNEPNET--TPLTEP--EKLPLKEE 779

  Fly   855 TG 856
            .|
Zfish   780 NG 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/86 (24%)
		IG_like	144..226	CDD:214653	29/83 (35%)
		IGc2	152..209	CDD:197706	21/58 (36%)
		I-set	230..319	CDD:254352	23/94 (24%)
		IGc2	243..309	CDD:197706	15/68 (22%)
		IG_like	330..424	CDD:214653	28/94 (30%)
		IGc2	339..412	CDD:197706	24/73 (33%)
		Ig	447..518	CDD:143165	22/70 (31%)
		fn3	534..611	CDD:278470	19/77 (25%)
		FN3	640..735	CDD:238020	27/97 (28%)
zgc:152904	NP_001070212.1	Ig	1..81	CDD:299845	21/88 (24%)
		IG_like	2..80	CDD:214653	21/87 (24%)
		IGc2	97..158	CDD:197706	21/60 (35%)
		Ig	177..273	CDD:299845	24/97 (25%)
		I-set	184..270	CDD:254352	20/87 (23%)
		Ig	272..369	CDD:299845	32/103 (31%)
		I-set	274..367	CDD:254352	31/99 (31%)
		IG_like	385..462	CDD:214653	24/76 (32%)
		IGc2	386..454	CDD:197706	22/67 (33%)
		FN3	468..561	CDD:238020	20/94 (21%)
		fn3	<591..650	CDD:278470	22/67 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2951
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm25496
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880