Protein Alignment Fas2 and BSG

DIOPT Version :10

• Sequence 1: NP_001284854.1
• Gene: Fas2 / 31364
• FlyBaseID: FBgn0000635
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_001719.2
• Gene: BSG / 682
• HGNCID: 1116
• Length: 385
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 71/326 - (21%)
• Similarity: 124/326 - (38%)
• Gaps: 72/326 - (22%)

  Fly   233 ISLPTNLEAVEGKPFAANCTARGKPVPEISWIRD-------ATQL-NVATADRFQVNP-----QT 284
            :..|.:.:...|.....:|.|.|.|||||.|..:       .:|| :.|..||..::.     ..
Human    26 VQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAA 90

  Fly   285 GLVTISSVSQDDYGTYTCLAKN-----------RAGVVDQKTKLNVLVRPQIYELYNVTGARTKE 338
            ..::|.::.::|.|||.|.|.|           |...|..:..:.||....::......|::
Human    91 STISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSK--- 152

  Fly   339 IAITCRAKGRPAPAITFRRW---GT--QEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAE 398
            |.:|| :....|..:|..||   |.  :|:...||:.:     .:.:.|::.||
Human   153 ILLTC-SLNDSATEVTGHRWLKGGVVLKEDALPGQKTE-----FKVDSDDQWGE----------- 200

  Fly   399 RSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEW 463
                  |.|:..   .:...|.:|.:...|....:|....:.  |...|.|.|.:..:|..| :|
Human   201 ------YSCVFL---PEPMGTANIQLHGPPRVKAVKSSEHIN--EGETAMLVCKSESVPPVT-DW 253

  Fly   464 HWNGRKIKDLYDTNLK--------IVGTGPRSDLIVHPVTRQYYSG-YKCIATNIHGTAEHDMQL 519
            .|  .||.|..|..|.        :..:..||:|.:..:..:...| |:|..|:..|:.:..:.|
Human   254 AW--YKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL 316

  Fly   520 K 520
            :
Human   317 R 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	Ig	33..121	CDD:472250
		Ig strand B	50..54	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	99..103	CDD:409353
		Ig strand F	113..118	CDD:409353
		Ig	139..209	CDD:472250
		Ig strand B	156..159	CDD:409353
		Ig strand C	168..172	CDD:409353
		Ig strand E	190..194	CDD:409353
		Ig strand F	204..209	CDD:409353
		IgI_4_MYLK-like	229..319	CDD:409568	26/109 (24%)
		Ig strand A	229..232	CDD:409568
		Ig strand A'	238..241	CDD:409568	0/2 (0%)
		Ig strand B	246..254	CDD:409568	1/7 (14%)
		Ig strand C	260..264	CDD:409568	2/3 (67%)
		Ig strand C'	267..270	CDD:409568	0/2 (0%)
		Ig strand D	277..281	CDD:409568	1/3 (33%)
		Ig strand E	285..290	CDD:409568	0/4 (0%)
		Ig strand F	298..306	CDD:409568	5/7 (71%)
		Ig strand G	309..319	CDD:409568	1/9 (11%)
		IG_like	330..424	CDD:214653	19/98 (19%)
		Ig strand B	339..343	CDD:409353	1/3 (33%)
		Ig strand C	352..356	CDD:409353	1/3 (33%)
		Ig strand E	388..394	CDD:409353	0/5 (0%)
		Ig strand F	404..409	CDD:409353	2/4 (50%)
		Ig	447..515	CDD:409353	20/76 (26%)
		Ig strand B	447..451	CDD:409353	2/3 (67%)
		Ig strand C	460..464	CDD:409353	1/3 (33%)
		Ig strand E	487..491	CDD:409353	2/3 (67%)
		Ig strand F	501..506	CDD:409353	3/5 (60%)
		FN3	525..619	CDD:238020
		FN3	640..735	CDD:238020
BSG	NP_001719.2	Ig0_BSG1	23..138	CDD:409534	27/111 (24%)
		Ig strand A	24..28	CDD:409534	0/1 (0%)
		Ig strand A'	29..35	CDD:409534	1/5 (20%)
		Ig strand B	38..47	CDD:409534	1/8 (13%)
		Ig strand C	52..60	CDD:409534	4/7 (57%)
		Ig strand C'	65..69	CDD:409534	0/3 (0%)
		Ig strand D	79..85	CDD:409534	0/5 (0%)
		Ig strand E	88..97	CDD:409534	1/8 (13%)
		Ig strand F	104..112	CDD:409534	5/7 (71%)
		Ig strand G	128..138	CDD:409534	2/9 (22%)
		Essential for interaction with KDR/VEGFR2. /evidence=ECO:0000269|PubMed:25825981	195..199		1/3 (33%)
		IG_like	228..318	CDD:214653	22/95 (23%)
		Ig strand B	238..242	CDD:409353	2/3 (67%)
		Ig strand E	283..287	CDD:409353	2/3 (67%)
		Ig strand F	298..303	CDD:409353	2/4 (50%)
		Ig strand G	311..314	CDD:409353	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..385