DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fas2 and Kirrel3

DIOPT Version :9

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:XP_006510620.1 Gene:Kirrel3 / 67703 MGIID:1914953 Length:803 Species:Mus musculus


Alignment Length:566 Identity:119/566 - (21%)
Similarity:200/566 - (35%) Gaps:167/566 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LTCRPT---VP---EPSLVADLQWKDNRNNTILPKP-----------NGRNQPPM--YTETLPGE 97
            :.||.|   :|   |.|:..|:|.....|.::.|:|           :.:..|.:  |.....|.
Mouse   225 IVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGH 289

  Fly    98 SLALMITSLSVEMGGKYYCTASY------ANTEILEK------GVTIKTYVAITWTNAPENQYPT 150
                :|...|.|:   |..|..|      .:.|:...      ..|:..|.....|:.|::....
Mouse   290 ----IIKEASGEL---YRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFG
PRMTSEPQSLLVD 347

  Fly   151 LGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAV--IE 213
            ||.|.|..|....:|:.||.|::.|..:..:|:|      .|.:::|::.|.|.|.|||.|  :.
Mouse   348 LGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEK------TLTLKSVRQEDAGKYVCRAVVPRVG 406

  Fly   214 TGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPE-ISWIRDATQLNVATADR 277
            .|| .|.|:.|.   .|.|||......|:.|:.....|..|..|.|: |:|......|...|:.|
Mouse   407 AGE-REVTLTV
N---GPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 467

  Fly   278 F---QVNPQTGLV---TISSVSQDDYGT-YTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGAR 335
            :   .||.:.|::   |||::.:.|:.| |.|.|.|..|   ..|:: :.::.|..|:.:..|..
Mouse   468 YTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFG---SDTEI-IRLK
EQGSEMKSGAGLE 528

  Fly   336 TKE------------------------IAITCRAKGRPA---PAITFRRWGTQ------------ 361
            .:.                        :|..|....|..   |.|:.|  ||:            
Mouse   529 AESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRPGISGR--GTEKKARLRLPRRAN 591

  Fly   362 -----------------EEYTNGQQDDDPRIILEPNFDEERGESTGTLR-----------ISNAE 398
                             :|.::|::.:|...|.:...|....:....|:           ..|.:
Mouse   592 LKGVVSAKNDIRVEIVHKEPSSGREAEDHTTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLK 656

  Fly   399 RSDDGLYQCIARNKGADAYKTGHITVEFA-----PDF--SHMKELPPVFSWEQRKANLSCLAMGI 456
            ...:|.|       ..:.:|..|.|...:     ||.  :..:.:|...|:....:.||      
Mouse   657 DPTNGYY-------SVNTFKEHHSTPTISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLS------ 708

  Fly   457 PNATIEWHWNGRKIKDLYDTNLK-IVGTGPRSDLIVHPVTRQYYSG 501
                    ..||    |||...: ::|.|..|   :....|::..|
Mouse   709 --------GQGR----LYDYGQRFVLGMGSSS---IELCEREFQRG 739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 IG_like 39..133 CDD:214653 22/111 (20%)
IG_like 144..226 CDD:214653 27/83 (33%)
IGc2 152..209 CDD:197706 17/56 (30%)
I-set 230..319 CDD:254352 29/96 (30%)
IGc2 243..309 CDD:197706 22/73 (30%)
IG_like 330..424 CDD:214653 20/160 (13%)
IGc2 339..412 CDD:197706 17/115 (15%)
Ig 447..518 CDD:143165 12/56 (21%)
fn3 534..611 CDD:278470
FN3 640..735 CDD:238020
Kirrel3XP_006510620.1 IG_like 54..143 CDD:214653
Ig strand A' 56..60 CDD:409353
Ig strand B 64..71 CDD:409353
Ig strand C 78..82 CDD:409353
Ig strand C' 84..87 CDD:409353
Ig strand D 97..101 CDD:409353
Ig strand E 104..116 CDD:409353
Ig strand G 132..143 CDD:409353
IgI_2_KIRREL3-like 149..246 CDD:409416 6/20 (30%)
Ig strand B 166..170 CDD:409416
Ig strand C 180..184 CDD:409416
Ig strand E 210..214 CDD:409416
Ig strand F 224..229 CDD:409416 1/3 (33%)
Ig strand G 239..242 CDD:409416 1/2 (50%)
Ig <267..334 CDD:416386 12/73 (16%)
Ig strand B 267..274 CDD:409353 0/6 (0%)
Ig strand C 279..286 CDD:409353 1/6 (17%)
Ig strand C' 288..291 CDD:409353 1/6 (17%)
Ig strand D 298..302 CDD:409353 1/6 (17%)
Ig strand E 304..310 CDD:409353 1/5 (20%)
Ig strand G 321..334 CDD:409353 2/12 (17%)
Ig 335..416 CDD:416386 27/87 (31%)
Ig strand A' 343..347 CDD:409353 0/3 (0%)
Ig strand B 350..360 CDD:409353 3/9 (33%)
Ig strand C 365..371 CDD:409353 3/5 (60%)
Ig strand E 381..387 CDD:409353 2/11 (18%)
IgI_5_KIRREL3 418..515 CDD:409479 29/100 (29%)
Ig strand B 436..440 CDD:409479 0/3 (0%)
Ig strand C 450..454 CDD:409479 1/3 (33%)
Ig strand E 481..485 CDD:409479 0/3 (0%)
Ig strand F 496..501 CDD:409479 2/4 (50%)
Ig strand G 509..512 CDD:409479 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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