DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and DSCAML1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens

Alignment Length:	1012	Identity:	224/1012 - (22%)
Similarity:	339/1012 - (33%)	Gaps:	313/1012 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGKPLILTCRPT-VPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTE-TLPGESLA-------- 100
            :|..:||:|..| .||    ..::|..|                  || .||.|:::
Human   340 IGSTVILSCALTGSPE----FTIRWYRN------------------TELVLPDEAISIRGLSNET 382

  Fly   101 LMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTL-----------GQD 154
            |:|||......|.|.|.|:       .|..|.:.:..|    |.|:..|.:           |:.
Human   383 LLITSAQKSHSGAYQCFAT-------RKAQTAQDFAII----ALEDGTPRIVSSFSEKVVNPGEQ 436

  Fly   155 YVVMCEVKADPNPTIDWLRNGDPI------RTTNDKYVVQTNGLLIRNV-----QESDEGIYTCR 208
            :.:||..|..|.||:.|..:.:||      ||  ::|.: ::|..|.::     |..|.|:|.|.
Human   437 FSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT--NQYTM-SDGTTISHMNVTGPQIRDGGVYRCT 498

  Fly   209 AAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDA------ 267
            |..: .|. .|...|:.|...|.|.:: .|:.||.|:....||...|.|...|.|.:||
Human   499 ARNL-VGS-AEYQARINVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN 560

  Fly   268 --------------------------------TQLNVATA-----------DRFQVNPQT----- 284
                                            .||:::.:           ..|:..|.:
Human   561 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLL 625

  Fly   285 --------------------------------------GLVTISSVSQDDYGTYTCLAKNRAGVV 311
                                                  ..:.|||||....|.|||:|.|.|..|
Human   626 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATV 690

  Fly   312 DQKTKLNVLVRPQ-IYELYNVTGARTKEIAITCRAKGRPAPAITFRR---WGTQEEYTNGQQDDD 372
            .::.:|.|.|.|: :.:..|..|...|...:.|...|.|.|.:.::.   .|..::|       .
Human   691 SRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQY-------H 748

  Fly   373 P-----RIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARN-KGADAYKTGHITVEFA---- 427
            |     ||.:.||         .:|.|.:....|.|.|.|.|.| .|.|..|:..:||:..
Human   749 PVPLTGRIQILPN---------SSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT 804

  Fly   428 --PDFS-----HMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKD-----LYDTNLKI 480
              |:.:     |.||             |:|.|.|.....|.|. .|..:.|     .|....|.
Human   805 SHPNTTIAIKGHAKE-------------LNCTARGERPIIIRWE-KGDTVIDPDRVMRYAIATKD 855

  Fly   481 VGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FVSEAKPSQLTAT-T 540
            .|....|.|.:.|..|.....:.|.|.|.:|.....:||.....||    .:.|.|...:... |
Human   856 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWT 920

  Fly   541 MTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYI----VEGLRPQTEYSFRFA 601
            ..||  |.|.     |..:.::||   |...|..:.:|....||.|    :..|.|.:.||.|..
Human   921 QRFD--GNSI-----ITGFDIEYK---NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 975

  Fly   602 ARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVP---ADNG 663
            :.|::|..........|| ..:||:.| |:...:|     ||.    |...::.|..|   ..||
Human   976 SFNKIGRSEPSKELTIST-EEAAPDGP-PMDVTLQ-----PVT----SQSIQVTWKAPKKELQNG 1029

  Fly   664 EPIDRYQIKY---CPGVKISGTWTELENSCNTVEVMETTS----FEMTQLVGNTYYRIELKAHNA 721
             .|..|||.|   .||          .|...::..|:.|.    :.:..|.....|.:.::|.|.
Human  1030 -VIRGYQIGYRENSPG----------SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1083

  Fly   722 IGYSSPASIIMKTTRGIDV-----IQVAERQVFSSAAIVG------IAIGGVLLLLFVVDLLCCI 775
            .| :.|:|..:..|...||     ..|....:.|..|::.      ..:.|||....|:.....:
Human  1084 AG-TGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYV 1147

  Fly   776 TVHMGVMATMCRKAKR-----------------SPSEIDDEAKLGSLYGWRFPLPYCSGQLVKEP 823
            ....|.|..:....:|                 :.::..|..:...||           ...||.
Human  1148 DGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLY-----------IQTKED 1201

  Fly   824 PPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQ 860
            .|.|   |..:|...|..|:.:....|...|.|.|::
Human  1202 VPGP---PAGIKAVPSSASSVVVSWLPPTKPNGVIRK 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/96 (25%)
		IG_like	144..226	CDD:214653	26/103 (25%)
		IGc2	152..209	CDD:197706	20/67 (30%)
		I-set	230..319	CDD:254352	32/180 (18%)
		IGc2	243..309	CDD:197706	24/157 (15%)
		IG_like	330..424	CDD:214653	25/102 (25%)
		IGc2	339..412	CDD:197706	19/81 (23%)
		Ig	447..518	CDD:143165	19/75 (25%)
		fn3	534..611	CDD:278470	21/81 (26%)
		FN3	640..735	CDD:238020	24/104 (23%)
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653
		IGc2	43..110	CDD:197706
		Ig	125..218	CDD:299845
		IG_like	137..209	CDD:214653
		I-set	245..323	CDD:254352
		IGc2	252..313	CDD:197706
		IGc2	340..401	CDD:197706	21/82 (26%)
		I-set	420..514	CDD:254352	25/98 (26%)
		Ig	420..510	CDD:299845	24/94 (26%)
		IGc2	531..589	CDD:197706	9/57 (16%)
		IG_like	619..698	CDD:214653	14/78 (18%)
		Ig	627..693	CDD:143165	13/65 (20%)
		I-set	702..797	CDD:254352	26/110 (24%)
		Ig7_DSCAM	719..797	CDD:143211	22/93 (24%)
		I-set	803..896	CDD:254352	25/106 (24%)
		Ig	815..903	CDD:299845	26/101 (26%)
		FN3	899..993	CDD:238020	25/103 (24%)
		FN3	1000..1097	CDD:238020	27/118 (23%)
		fn3	1105..1191	CDD:278470	11/85 (13%)
		FN3	1203..1294	CDD:238020	10/36 (28%)
		IGc2	1318..1382	CDD:197706
		FN3	1396..1486	CDD:238020
		FN3	1500..1572	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910