DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and dscama

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	764	Identity:	189/764 - (24%)
Similarity:	300/764 - (39%)	Gaps:	143/764 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LTCR-PTVPEPSLVADLQW--------KDNRNNTILPKPNGRNQPPMYTETLPGESLA-LMITSL 106
            |||. ...|:|::.    |        ||:|:..:            ::.|..|..:: |.|:.:
Zfish   427 LTCHVKGTPQPAIT----WTLDDEVVAKDSRHRIV------------HSITAEGNVVSYLNISHI 475

  Fly   107 SVEMGGKYYCTA-SYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTID 170
            .|...|.|.||. :.|.|...:..:.::....|   ...:|.....|.|..:.|.|...|..:|.
Zfish   476 QVRDSGVYRCTCNNSAGTVSYQARINVRGSADI---RPMKNLTAIAGWDMYIHCHVIGYPYYSIK 537

  Fly   171 WLRNGDPIRTTNDKYVVQTNGLL-IRNVQ-ESDEGIYTCRAAV---IETGELLERTIRVEVFIQP 230
            |.:|.:.:...:.:...:.||.| :.||| |.|||.|:|...|   :...:.:..|::|..||||
Zfish   538 WFKNSNLLPFNDRQRAFENNGTLKLLNVQKELDEGEYSCHVQVQPQLFKNQSVHVTVKVPPFIQP 602

  Fly   231 EIISLPTNLEAVEGKPFAANCTARGKPVP-EISWIRDATQLNVA---TADRFQVNPQTGLVTISS 291
              ...|.  .::..:.|.. |..|...:| .|:|.:|...:|.:   |.|....   |..:.||:
Zfish   603 --FEFPR--YSIGHRVFVP-CVVRSGDLPISITWEKDGKSINASLGVTIDNIDF---TSSLRISN 659

  Fly   292 VSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQI-YELYNVTGARTKEIAITCRAKGRPAPAITF 355
            :.:...|||||:|:|.|.||..:::|.|.|.|:. .:..:..|...|.:.:.|.|.|.|.|.|
Zfish   660 LQRVHNGTYTCIAQNDAAVVKYQSQLIVRVPPRFKVQPQDQDGIYGKSVILNCSADGEPRPTI-- 722

  Fly   356 RRWGTQEEYTNGQ--QDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQC-IARNKGADAY 417
             .|    :|:.|.  ....| |.|...|..:. ...|:|.|.:....|.|.|.| ::.:.|||..
Zfish   723 -EW----KYSKGAGVPQFQP-IALNSGFRVQL-LGNGSLLIKHVLEEDAGYYLCKVSNDVGADVS 780

  Fly   418 KTGHITVEFA------PDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDT 476
            |:.::.|:..      |:.|        .:.:..|..:||.|.|.....:.|.....|.|..:..
Zfish   781 KSMYLNVKIPAMITSYPNNS--------LATKGEKIEMSCKAHGEKPIMVRWEKEVEKEKQSHMI 837

  Fly   477 N---------LKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FV 528
            |         :|.||....|.|.::|..|:....:.|.|.|.:|.....:||.....|:    .:
Zfish   838 NPDMWRHTVTVKNVGDEVVSTLQIYPTMREDSGFFSCHAINSYGEDRGILQLTVQEPPEPPKVEI 902

  Fly   529 SEAKPSQLTAT-TMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTA-YNRSWSP--DSPYIVEG 589
            .|.|...:... ||.||  |.|.     |..|.::.|.. ...|..| ..|..||  :...|:|
Zfish   903 REVKERTIALRWTMGFD--GNSL-----ITGYDIECKNK-TETWERARRTRDVSPTLNQATIIE- 958

  Fly   590 LRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFEL 654
            |.|.:.|:.|..|:|.:|      :.:.|.......:|..| ..|.|....|.:.    |...::
Zfish   959 LHPSSTYNIRMFAKNHIG------DSEPSNELTVTTDEADP-EGPPQDVTLEAIT----SQSIKV 1012

  Fly   655 RWGVP---ADNGEPIDRYQIKY------------CPGVKISGTWTELENSCNTVEVMETTSFEMT 704
            .|..|   ..|| .|..||:.:            |..|:.:|               ||.|..:.
Zfish  1013 TWKAPLKHLQNG-VIRGYQVCHREHSTNGSHQFVCISVEATG---------------ETESLSLN 1061

  Fly   705 QLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAA 753
            .|.....|.:.::|.|:.| ..|||..::.|...||...|..:|.::||
Zfish  1062 NLKKFAEYEVVVQASNSAG-PGPASSEVRATTMEDVPSRAPEKVVATAA 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/91 (22%)
		IG_like	144..226	CDD:214653	24/86 (28%)
		IGc2	152..209	CDD:197706	20/58 (34%)
		I-set	230..319	CDD:254352	26/92 (28%)
		IGc2	243..309	CDD:197706	20/69 (29%)
		IG_like	330..424	CDD:214653	26/96 (27%)
		IGc2	339..412	CDD:197706	20/75 (27%)
		Ig	447..518	CDD:143165	19/79 (24%)
		fn3	534..611	CDD:278470	23/80 (29%)
		FN3	640..735	CDD:238020	23/109 (21%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142
		I-set	236..311	CDD:254352
		IG_like	321..402	CDD:214653
		I-set	408..502	CDD:333254	20/90 (22%)
		IGc2	524..579	CDD:197706	18/54 (33%)
		Ig	614..679	CDD:319273	21/68 (31%)
		Ig_DSCAM	708..787	CDD:143211	24/87 (28%)
		Ig	805..898	CDD:325142	23/92 (25%)
		FN3	894..988	CDD:238020	27/108 (25%)
		FN3	995..1092	CDD:238020	25/117 (21%)
		fn3	1100..1186	CDD:306538	4/10 (40%)
		fn3	1199..1282	CDD:306538
		Ig	1312..1377	CDD:319273
		fn3	1405..1471	CDD:306538
		FN3	1492..1563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900