DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and aebp1b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	809	Identity:	148/809 - (18%)
Similarity:	260/809 - (32%)	Gaps:	272/809 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTE----ILEKGVT----------IKT 134
            |||     :||....|:|::.|..|. |...:..:..::|:    :.::.||          |..
Zfish     5 RNQ-----KTLVVLCLSLLVPSWEVN-GLTEHSKSEISHTDREQHVEDRNVTSVEDLLQVKIIPP 63

  Fly   135 YVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLR-NGDPIRTTNDKYVVQTNG-----LL 193
            |..|           .:||...::|:|.:|.. .|:|:. ||:.:.|.:....|..:|     |.
Zfish    64 YATI-----------EVGQHKQLLCKVSSDAK-NINWVSPNGEKVLTKHGNLKVHNHGSVLSSLT 116

  Fly   194 IRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVE---------GKPFAA 249
            :.|...::.|||.|.|...:|..  :.|:::::.::.  :...|:.:..|         .||.|:
Zfish   117 VLNANLNNAGIYKCVATNGDTES--QATVKLDIILKR--MRRDTDRKGREKRLKEPKPSKKPKAS 177

  Fly   250 NCTARGK---------------------------------------------PVPEISWIRDATQ 269
            ..|.:.|                                             |.|:..|..| ..
Zfish   178 KPTKKPKSEKKGKGEKGGKKKGKKNREESTTVATTTVAPTTTVPMEYEEFYDPEPDQYWDED-FP 241

  Fly   270 LNVATADRFQVNP----QTGLVTISSVSQ-DDYGTYTCLAKNRAGVVDQKTKLNVLV--RP---- 323
            ....|..|....|    :..:..:...|| |.|..|        ..||:.|....::  ||
Zfish   242 AETTTVARTTTTPTEKTKDFIPDMDEYSQPDSYDDY--------WKVDEPTPTTSVIAGRPADDD 298

  Fly   324 ------QIYELYNVTGARTKEIAIT-----CRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIIL 377
                  .:..:.|:.....|||:.|     ......|........|..:.||.:.::.::.|..|
Zfish   299 DYWDARSVEMVENLPFPDGKEISSTDNDWQYTTTEEPTVPPFENSWYEEYEYGHEKKLEEERERL 363

  Fly   378 EPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSW 442
            ....:|:..|....|.....||.   :|:                              ||...:
Zfish   364 RKEQEEKEREERKRLEEEERERR---IYR------------------------------PPPRVY 395

  Fly   443 EQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIAT 507
            .:.|.   |..:|:.:..|:                       ...|:...|.:..|..::. ..
Zfish   396 REPKI---CPPLGMESHRID-----------------------NDQLLTSSVFQHRYGSHRA-RL 433

  Fly   508 NIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWS 572
            ||..:.:.|.....|...:...:....::.|.|:| :..|..|:          ...:.|..|:.
Zfish   434 NIQASGDDDDMNGGAWCANPEEKVHWIEVDARTLT-EFTGVITQ----------GRDDPLESDYV 487

  Fly   573 TAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNW---GVNQQQSTPRRSAPEEPKPLHNP 634
            :.|..::|.||          .|::|.     ..|...|   | |..::||..|...||
Zfish   488 STYYVAFSNDS----------REWTFL-----HDGYAEWLFFG-NSDKNTPVLSQFMEP------ 530

  Fly   635 VQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVK--ISGTWTELE---------- 687
                     ||:.|.......|     ||....|.:|..|| |:  :|...:|.|
Zfish   531 ---------VVARYIRILPQSW-----NGTMCMRMEILGCP-VQDPLSQHQSENEVTRRDNLDYT 580

  Fly   688 --NSCNTVEVMETTSFEMTQL-----VGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAE 745
              |..:..::|::.|.|...:     :|.::..:|:.|             |:.|....|.:..|
Zfish   581 HHNYLDMEKLMKSISDECPNITRFYSLGKSFKGLEIYA-------------MEITDNPGVHETGE 632

  Fly   746 RQVFSSAAIVG-IAIGGVLLLLFVVDLLC 773
            .:...:|...| .|:|..|||:| :..||
Zfish   633 PEFRYTAGYHGNEALGRELLLMF-MQYLC 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	13/62 (21%)
		IG_like	144..226	CDD:214653	21/87 (24%)
		IGc2	152..209	CDD:197706	18/62 (29%)
		I-set	230..319	CDD:254352	22/147 (15%)
		IGc2	243..309	CDD:197706	18/124 (15%)
		IG_like	330..424	CDD:214653	17/98 (17%)
		IGc2	339..412	CDD:197706	14/77 (18%)
		Ig	447..518	CDD:143165	9/70 (13%)
		fn3	534..611	CDD:278470	14/76 (18%)
		FN3	640..735	CDD:238020	22/113 (19%)
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	24/104 (23%)
		IG_like	62..145	CDD:214653	23/96 (24%)
		FA58C	402..555	CDD:238014	39/223 (17%)
		FA58C	403..556	CDD:214572	39/223 (17%)
		Peptidase_M14_like	577..1036	CDD:299699	21/98 (21%)
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900