DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and igsf9ba

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_009289969.2	Gene:	igsf9ba / 567389	ZFINID:	ZDB-GENE-060503-729	Length:	1475	Species:	Danio rerio

Alignment Length:	1026	Identity:	221/1026 - (21%)
Similarity:	352/1026 - (34%)	Gaps:	304/1026 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLALLLCSCSLIELTRAQSPILEIYPKQEVQRKP------VGKPLILTCRPTVP-----EPSLVA 65
            ::|.|:.|......|.||.       ...|:.:|      .|:.::|.|..:.|     .|.:|
Zfish     4 YVATLIASVFSTRGTAAQG-------AHGVREEPQFVTARAGESVVLGCDVSHPLNGQQTPYVV- 60

  Fly    66 DLQW-KDNRNNTILPKP---NGRNQPPMYTETLPGES-----LALMITSLSVEMGGKYYCTASYA 121
              :| |..     :|.|   |.|..||.......|.:     .:|.|..:..|..|.|.|
Zfish    61 --EWFKFG-----VPIPFFINFRFYPPHVDPEYAGRASLHGKASLQIEQVRSEDQGWYEC----- 113

  Fly   122 NTEILEKGVTIKTYVAITWTNAPENQYPTL------------GQDYVVMCEVKADPNPTIDWLRN 174
              .:|.......|:...:|.:...|..||.            |....:.|....:|.|.:.|||.
Zfish   114 --RVLMLEQQYDTFHNGSWVHLTVNAPPTFSDTPPQYVEAREGGSITLTCTAFGNPKPVVTWLRE 176

  Fly   175 GDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNL 239
            ||.:.:|. ||.|....|.::.:...|.|.|:|||. .:.||.| .|.|:.|...|.|::.|.|:
Zfish   177 GDQLTSTR-KYTVSDGSLTVQAITREDRGAYSCRAH-SDQGEAL-HTTRLLVQGPPYIVTPPENI 238

  Fly   240 EAVEGKPFAANCTARGKP---VPEISWIRDATQLNVATADRFQVNPQ---TGLVTISSVSQDDYG 298
            .....:.....|.|...|   .....|..|    ||...:..::..:   .|.:.|..|..:|.|
Zfish   239 TVNISQNAQFTCQAEAYPGNLTYTWYWEED----NVYFKNDLKLRVRIFIDGTLIIYRVKPEDAG 299

  Fly   299 TYTCLAKNRAGV---------VDQKTKLNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAIT 354
            .|||...|..|:         |....:: |.:.|.||....::|      .|.|.....  |.:|
Zfish   300 KYTCSPSNSLGISPSASAYLTVQYPARV-VNMPPVIYVPRKLSG------IIRCPVDAN--PPVT 355

  Fly   355 FRRWGTQEEYTNGQQDDDP-RIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYK 418
            ..||         ::|..| ||...|.:.:   .:.|::|::.......|.|.|:..|...
Zfish   356 SVRW---------EKDGYPLRIEKYPGWSQ---MTDGSIRVAEVTEDSLGTYTCVPYNVLG---- 404

  Fly   419 TGHITVEFAPDFSHMKELPPVFS------WEQ---RKANLSCLAMGIPN-ATIEWHWNGRKIKDL 473
                |:..:|..:.:.:.||.|:      :.|   |:..:.|.|.|.|. .||:|...|:..:..
Zfish   405 ----TMGQSPPATLVLKDPPYFNVRPGGEYRQEAGRELVIPCAASGDPEIPTIQWRKVGKPSRSK 465

  Fly   474 YDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTA 538
            :  ||.     |...|....::::.:..::|:|||:                       .:.:||
Zfish   466 H--NLL-----PSGSLQFVSLSKEDHGEWECVATNV-----------------------VTSITA 500

  Fly   539 TTMTFDI-RGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWS---------------------- 580
            :|..|.| ..|.....:.:.|.:.....:..|.:...:.:::|
Zfish   501 STRLFVIGTSPHAPTNVHVSASTSSANVSWEPGYDGGFEQTFSVWYGPVKVKNDVGTHDWLSIPV 565

  Fly   581 PDSP--YIVEGLRPQTEYSFRFAARNQVGLGNWGV-------NQQQSTPRRSAPEEPKPLHNP-- 634
            |.|.  .:|:||.|:|.|.|...|:|::|.|.:..       ....|||      ||..|..|
Zfish   566 PGSQMWLVVQGLEPKTAYQFSVLAQNKLGTGPFSEVVTVTTGGYPISTP------EPLVLLTPPR 624

  Fly   635 -VQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMET 698
             :..::.:..|:        |.|..||::..|||||.|::..|.|    |..|::.....|
Zfish   625 CLTANRTQQGVL--------LTWLPPANHTSPIDRYVIEFRLGEK----WEVLDDLIPATE---- 673

  Fly   699 TSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVL 763
            |......|:.:::|  |.:|                      :.:.:..|..|:.:||::.....
Zfish   674 TEIIARDLIQDSWY--EFRA----------------------LAIMDDLVSESSNVVGVSSTDPF 714

  Fly   764 LLLFVVDLLCCITVHMGVMATMC-----------------------RKAKRSP--------SEID 797
            ....:.|......|..|::||:|                       .|.||.|        ..|:
Zfish   715 PPTEISDEGLAKPVVAGIVATICFLAAAILFSTLAACFVNKQHRRKLKRKRDPPLSITHTRKSIE 779

  Fly   798 DEAKLGSLYG----WRFP------LPYCSGQLV--KEPPPSPLPLPPP--VKLGG-----SPMST 843
            ....|..|.|    |..|      .|..|.||.  |..|.|.....||  ..:||     ..:.:
Zfish   780 SPPPLTPLPGIEPYWEEPDRSSYRPPSTSPQLSSGKISPESIASSRPPSLASVGGHGLYVKKLPS 844

  Fly   844 PLDEKE-----------------------PLRTPTGSIKQNSTIEFDGRFV 871
            |..|||                       .:.||...|.:..    |||||
Zfish   845 PRKEKELSLYKKTKRAITSKKYSVSKHEAEVTTPIELISRGP----DGRFV 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/113 (21%)
		IG_like	144..226	CDD:214653	28/93 (30%)
		IGc2	152..209	CDD:197706	18/56 (32%)
		I-set	230..319	CDD:254352	22/103 (21%)
		IGc2	243..309	CDD:197706	16/71 (23%)
		IG_like	330..424	CDD:214653	18/94 (19%)
		IGc2	339..412	CDD:197706	16/73 (22%)
		Ig	447..518	CDD:143165	16/71 (23%)
		fn3	534..611	CDD:278470	22/101 (22%)
		FN3	640..735	CDD:238020	21/94 (22%)
igsf9ba	XP_009289969.2	IG	30..115	CDD:214652	22/99 (22%)
		I-set	139..225	CDD:254352	27/88 (31%)
		I-set	229..321	CDD:333254	21/95 (22%)
		Ig	345..415	CDD:325142	18/91 (20%)
		Ig	438..503	CDD:319273	18/94 (19%)
		FN3	511..606	CDD:238020	17/94 (18%)
		FN3	622..706	CDD:238020	24/123 (20%)
		Atrophin-1	<924..1361	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900