DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and ncam3

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_017207042.1	Gene:	ncam3 / 566122	ZFINID:	ZDB-GENE-131127-340	Length:	688	Species:	Danio rerio

Alignment Length:	745	Identity:	204/745 - (27%)
Similarity:	313/745 - (42%)	Gaps:	129/745 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNG-----LLIRNVQESDEGIYTCRAA 210
            :|...:::|  |||....|:||::|:.:.|  |::||:.|.     |.::|||.||.|.|||.
Zfish    30 VGNSILLLC--KADTEGDINWLKDGEDVDT--DRHVVEKNDESSSTLNLKNVQLSDTGRYTCE-- 88

  Fly   211 VIETGELLERTIRVEVFI--QPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVA 273
             .|.....::|...::::  .|:.....|..|.:..:.....|...|||..||.|.|:...::..
Zfish    89 -FEDSNGNKKTTNSQIYVYKTPDFGQTRTFHEFLVNQTAIIPCMVTGKPEVEIHWFRNDRMIHDD 152

  Fly   274 TADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVR--PQIY---ELYNVTG 333
            .....::.|...|: |..:..:|.|||.|..|.:...:.:...::|:|.  |.:.   |..:|..
Zfish   153 GRSHLKILPDRTLM-IVGIQHEDRGTYICEGKIKGRPITRNLPISVVVNEPPTVLIHEEKKSVFA 216

  Fly   334 ARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAE 398
            .....::|.|..||.|.|.||   |.|...:      :|.|.    :::.::.|    |.||...
Zfish   217 GPNTSLSIACLVKGAPVPTIT---WTTPSSF------NDYRY----SYNTDKSE----LTISAVT 264

  Fly   399 RSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQR-------KANLSCLAMGI 456
            |||.|.|.|.|.|      |.|..:..|..|.|   |||.|...|.:       .|::.|.|.|.
Zfish   265 RSDYGEYICTASN------KIGESSAIFVLDVS---ELPTVVFTENKLSIIPGESASVFCNATGH 320

  Fly   457 PNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKE 521
            |...::|   .||     ||..|:.|   ..:||:..:.......|.||||||.||...|.||
Zfish   321 PAPAVQW---VRK-----DTQQKMSG---EPELILENIMPSDGGFYSCIATNIVGTTTGDFQL-- 372

  Fly   522 ARVPDFVSEAKPSQLTATTMTFDIRGPSTEL----------GLPILAYSVQYKEALNPDWSTAYN 576
                 ......|||.:.:.      |.|:.:          |.||..|.:|:|:....:|:   .
Zfish   373 -----ITWPETPSQFSMSA------GSSSAILIHSVSVQDGGSPISYYILQWKKPSEDNWN---Q 423

  Fly   577 RSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEE 641
            ....|..|.:::.|.|.||||.|.||:|....||:...|...|..|.. |...|:.:..:...|:
Zfish   424 NIVKPAYPLMIKDLEPYTEYSVRIAAKNSHYQGNFSTEQNIFTQSRHG-EPDSPVLSLSEKKLEK 487

  Fly   642 PVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQL 706
            ..|..|..   :|:     |.|.||.:|.::| .|.|....|||     ||:. ..::..::..|
Zfish   488 NSVSIPIK---QLK-----DGGSPILQYIVRY-KGSKEKEEWTE-----NTIP-GNSSRIQLNDL 537

  Fly   707 VGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDL 771
            ..|..|.:|:.|.|..|.||||.:      ...|.|...:.......:|||.:...|:|:..||.
Zfish   538 QYNADYHLEVYAVNHNGSSSPAKV------NFTVPQPISQPALGKGGVVGIVMFIFLVLMVSVDA 596

  Fly   772 LCCITVHMGVMATMCRKA---KRSPSE-IDDEA-------KLGSLYGWRFPLPYCSGQLVKEPPP 825
            .||.|.|.|::..:.||.   |.:.:: ||:||       ||..|     .||..|...::.|..
Zfish   597 FCCYTNHCGLLNFLARKLLGHKMAETKGIDEEANNSTGDMKLSGL-----TLPRGSIPKLQAPNG 656

  Fly   826 SPLPLPPPVKLGGSPMSTPLDEKEPLRTPT 855
            :...:...|....:|: |..::|.....||
Zfish   657 AVNGVHSEVTCDKAPL-TKFEKKPESTDPT 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	26/79 (33%)
		IGc2	152..209	CDD:197706	24/61 (39%)
		I-set	230..319	CDD:254352	20/88 (23%)
		IGc2	243..309	CDD:197706	17/65 (26%)
		IG_like	330..424	CDD:214653	27/93 (29%)
		IGc2	339..412	CDD:197706	23/72 (32%)
		Ig	447..518	CDD:143165	24/70 (34%)
		fn3	534..611	CDD:278470	24/86 (28%)
		FN3	640..735	CDD:238020	28/94 (30%)
ncam3	XP_017207042.1	I-set	18..99	CDD:254352	25/75 (33%)
		IGc2	31..94	CDD:197706	25/69 (36%)
		IG_like	122..197	CDD:214653	17/75 (23%)
		IGc2	123..182	CDD:197706	16/59 (27%)
		Ig	202..290	CDD:299845	30/110 (27%)
		I-set	212..290	CDD:254352	28/100 (28%)
		IGc2	307..364	CDD:197706	21/67 (31%)
		FN3	376..466	CDD:238020	27/98 (28%)
		fn3	<499..558	CDD:278470	21/65 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930