DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and sdk1a

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	863	Identity:	193/863 - (22%)
Similarity:	288/863 - (33%)	Gaps:	242/863 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMG 111
            |..|::||   :.|.|...:.:|..|..:.....|..:     ||           |:||.....
Zfish   140 GNRLVMTC---LAEGSWPLEFKWMLNNTDITAFSPEYK-----YT-----------ISSLQRSNM 185

  Fly   112 GKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCE---VKADPNPTIDWLR 173
            |.|.|........:|:|...|:  ||........:|..|:.|....:..   |...|.|.:.|.|
Zfish   186 GVYQCVVRNRMGALLQKKAEIQ--VAYMGDFIDNDQRKTVTQGRAAILNSPAVSCFPRPQVTWFR 248

  Fly   174 NGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGE---------------------- 216
            :|..|..:|...:...|.|::.....||.|.|..:|...:.||
Zfish   249 DGYKIIPSNRIAITLENQLVVLGTAASDAGRYYVQAVNEKNGENKTSPSIYLNVAANKKYRGSHD 313

  Fly   217 ------------------------LLERTIR-------------------VEV------------ 226
                                    :.|.|:.                   |||
Zfish   314 SEAPADPVAPVIVIPPRNTTVVAGISEATLECVANARPVEKLSLVWRRNGVEVASGVGSFSRRLT 378

  Fly   227 FIQP----------EIISLPTNLEAVEGKPFAA-------------------------NCTARGK 256
            .|.|          |.:.|.::::..|.:.|.:                         .|.|||.
Zfish   379 IINPTSTDVGMYVCEALLLDSSVKPAEARAFLSITEAPYFTAEPRRKMMGEVEKSVDIQCQARGV 443

  Fly   257 PVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNV-- 319
            |:|::.|.:||..|:.....|:::....|| .:..:...|.|.:.|.|:|.||.....|.|:|
Zfish   444 PMPKLEWYKDAVPLSKLNNPRYKIISSMGL-QVRKLQPSDAGIFQCFARNSAGEAQVHTYLDVTS 507

  Fly   320 ----LVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRI-ILEP 379
                ...|.:    ::|.......|.|||..|.|.|||.:|| .||...:...|  .||. :||
Zfish   508 MAPAFTAPPL----DITVTDGAVAAFTCRVSGAPKPAIVWRR-DTQILASGSVQ--IPRFTLLE- 564

  Fly   380 NFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQ 444
                     :|.|:|......|.|.|.|.|.|.......:..:||......|.    ||.   ::
Zfish   565 ---------SGGLQIQPVVLQDTGNYTCYAANSEGAINASASLTVWSRTSISS----PPT---DR 613

  Fly   445 R-----KANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDL---IVHPVTRQYYSG 501
            |     .|.|.|.|...|...:.:.|.       .|..|.....|.|..|   .:|  ..|.:||
Zfish   614 RVIKGTTAILECGATHDPRVGVRYVWK-------KDEELVSHSRGGRISLQEGSLH--ISQTWSG 669

  Fly   502 ----YKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTEL--------GL 554
                |.|...:..|.     :.||||:........|..|.|:....|.|  |.:|        ..
Zfish   670 DIGNYTCDVISEAGN-----ESKEARLEVIELPHSPRNLQASLNANDSR--SVDLSWMRPFDGNS 727

  Fly   555 PILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQST 619
            |:|.|.|:..|..:| |....:......:..:|:||.|...|.||..|.||||.|.:..    .|
Zfish   728 PLLHYVVELSENNSP-WRVYLSDVDPSGTGAMVKGLTPARSYQFRVCAVNQVGRGQYST----ET 787

  Fly   620 PRRSAPEEP--KPLHNPVQHDKEEPVVVSPYSDHFELRWGVPAD---NG---EPIDRYQIKYCPG 676
            .|....|||  .|..|.|...:....::        ::|..|.:   ||   ..:.||::...||
Zfish   788 NRLMLREEPPSAPPKNIVASGRTNQSIM--------VQWQPPPEPQLNGVLRGYVLRYRLAGLPG 844

  Fly   677 VKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIG---YSSPASIIMKTTRGI 738
                      |.....:...|.....:|:|:..|.|.|::.|:...|   :|.|  :...|.:|:
Zfish   845 ----------EYQQKNISSPEINYCLITELIIWTQYEIQVAAYTGAGLGVFSQP--VTEYTLQGV 897

  Fly   739 DVI--QVAERQVFSSAAI 754
            ...  |..|.:..:|..|
Zfish   898 PTAPPQGVEAKAVNSTTI 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	19/85 (22%)
		IG_like	144..226	CDD:214653	23/149 (15%)
		IGc2	152..209	CDD:197706	15/59 (25%)
		I-set	230..319	CDD:254352	27/123 (22%)
		IGc2	243..309	CDD:197706	20/90 (22%)
		IG_like	330..424	CDD:214653	28/94 (30%)
		IGc2	339..412	CDD:197706	26/73 (36%)
		Ig	447..518	CDD:143165	18/77 (23%)
		fn3	534..611	CDD:278470	26/84 (31%)
		FN3	640..735	CDD:238020	19/103 (18%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352	20/88 (23%)
		Ig	125..204	CDD:299845	19/82 (23%)
		IG_like	222..302	CDD:214653	19/79 (24%)
		Ig	236..287	CDD:299845	15/50 (30%)
		Ig_3	322..394	CDD:290638	7/71 (10%)
		I-set	323..412	CDD:254352	11/88 (13%)
		I-set	416..505	CDD:254352	22/89 (25%)
		Ig	436..500	CDD:299845	20/64 (31%)
		I-set	510..600	CDD:254352	29/106 (27%)
		Ig	527..600	CDD:299845	27/85 (32%)
		I-set	605..693	CDD:254352	26/108 (24%)
		Ig	610..693	CDD:299845	24/99 (24%)
		FN3	697..788	CDD:238020	27/97 (28%)
		fn3	800..886	CDD:278470	20/103 (19%)
		FN3	901..997	CDD:238020	4/15 (27%)
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900