DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and il1rapl1b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001136054.1	Gene:	il1rapl1b / 557801	ZFINID:	ZDB-GENE-090109-2	Length:	700	Species:	Danio rerio

Alignment Length:	672	Identity:	132/672 - (19%)
Similarity:	213/672 - (31%)	Gaps:	249/672 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LQWKDNRNNTILPKP---NGRNQPPMYTETLPGESLALMITSLSVEMGGKYYC---TASYANTEI 125
            |.|..:..:|...:|   :|       |.||..|. ||......::..|.|.|   .:||.
Zfish    74 LMWYRSATHTDHEEPITLDG-------TRTLKEED-ALWFRPAQLQDSGHYSCVLRNSSYC---- 126

  Fly   126 LEKGVTIKTYVAITWTNAPEN-------------QYPTLGQDYVVMCE-----VKADPNPTIDWL 172
                  :|..:|:|   ..||             :...|.:...::|.     ..|...|.:.|.
Zfish   127 ------MKVSMALT---VAENSSGLCYNSKMRRLEKAELSKSKDILCPDIQDYTPAGSEPHVTWY 182

  Fly   173 RNGDPIRTTNDKYVVQTNGLL-IRNVQESDEGIYTCRAAVIETGE-LLERTIRVEVFI-----QP 230
            :...|.:..:.  :::|..|| ||:|:|.|.|.|||.   |:.|. |:.||..:.|..     .|
Zfish   183 KECRPKQWRSS--IIRTADLLSIRDVREDDIGNYTCE---IQFGRFLVRRTTELTVTAPLTDKPP 242

  Fly   231 EIISLPTN----LEAVEGKPFAANCTA----RGKPVPEISW------IRDATQLNVATADRFQVN 281
            :|:..|.:    :|...|.|....|.|    .|...|.|.|      |.|..:..:..::...|.
Zfish   243 KILQPPEHKLSVMELQLGGPVNLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDETRIRESEIKMVR 307

  Fly   282 PQTG------LVTISSVSQDDYGTYTCLAKN----RAGVVDQKTK----------------LNVL 320
            ...|      .:||.|:.::|.|.|:|..:|    |..::....:                |.::
Zfish   308 EHLGEQEVSVSLTIDSLQEEDLGNYSCYVENGHGRRHAIIQLSRRELMYTVELAGGLGAILLMLI 372

  Fly   321 VRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTN--GQQDDDPRIILEPNFDE 383
            ....:|:.|.:      |:.:.                     |.|  |.:|.|
Zfish   373 FLVSLYKCYRI------ELMLF---------------------YRNHFGSEDVD----------- 399

  Fly   384 ERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKAN 448
              ||                       ||..||| ..:..|:  ||           .|.|....
Zfish   400 --GE-----------------------NKDYDAY-VSYTKVD--PD-----------QWSQETRE 425

  Fly   449 LSCLAMGIPNATIEWHWNGRKI----KDLYDTNLKI------VGTGPRSDLIVHP--VTRQYYSG 501
            ....|:.|....:|.|: |.|:    :||..|...|      |....|..:::.|  |.|:.:|.
Zfish   426 EEHFALEILPDMLEKHY-GYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSI 489

  Fly   502 YKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEA 566
            :           |.:.:|:...|.   .|.|...:..:    |:||......:..|.::::....
Zfish   490 F-----------ELETRLRNMLVS---GEIKVILIECS----DLRGIMNYQEVEALKHTIKLLTV 536

  Fly   567 L---NPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEP 628
            :   .|..|...:|.|.            |.:|...|                    ||   .||
Zfish   537 IRWPGPGSSKPNSRFWK------------QLQYEMPF--------------------RR---PEP 566

  Fly   629 KPLHNPVQHDKEEPVVVSPYSD 650
            |..|..|....|:    .|:.:
Zfish   567 KLSHEQVLDASEQ----GPFGE 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	16/71 (23%)
		IG_like	144..226	CDD:214653	25/101 (25%)
		IGc2	152..209	CDD:197706	17/62 (27%)
		I-set	230..319	CDD:254352	26/128 (20%)
		IGc2	243..309	CDD:197706	21/85 (25%)
		IG_like	330..424	CDD:214653	13/95 (14%)
		IGc2	339..412	CDD:197706	7/74 (9%)
		Ig	447..518	CDD:143165	17/82 (21%)
		fn3	534..611	CDD:278470	11/79 (14%)
		FN3	640..735	CDD:238020	2/11 (18%)
il1rapl1b	NP_001136054.1	PHA02785	7..334	CDD:165149	67/285 (24%)
		Ig	32..135	CDD:299845	19/81 (23%)
		Ig	148..234	CDD:299845	23/90 (26%)
		Ig	263..348	CDD:143165	19/84 (23%)
		TIR	405..559	CDD:279864	39/198 (20%)
		Required for synaptic vesicle accumulation during synaptogenesis	564..700		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000