DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and igsf9a

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_005155702.1	Gene:	igsf9a / 557459	ZFINID:	ZDB-GENE-060503-288	Length:	1619	Species:	Danio rerio

Alignment Length:	950	Identity:	199/950 - (20%)
Similarity:	344/950 - (36%)	Gaps:	196/950 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PILEIY-----------PKQEVQRKPVGKPLILTCRPTVPEPSLVAD---LQWKDNRNNT----- 76
            |:||:.           ..:|..|.......:|.|....|:....|.   ::|.....:|
Zfish     7 PLLEVIVAVLCLFNDTSAAEEHVRAKKDSSAVLPCSLPAPQKDSSASQYVIEWVRQGFDTPIFMQ 71

  Fly    77 ------ILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKG------ 129
                  :.|..:||      .....|.|  |.::.|.:|..|.|.|.....:....|.|
Zfish    72 LGVHPRVHPDYDGR------VSLFGGTS--LQMSGLQLEDEGWYECRILPLDQTTEEAGSSGSWT 128

  Fly   130 -VTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNG-L 192
             :::.....:|.|:.||.:. .:|:...:.|..:.:|.|||.|.::|.||:..:.  |...|| :
Zfish   129 RLSVTAPPVLTETSPPEVEV-FVGRSLTLKCAAQGNPRPTITWSKDGAPIKPQHK--VKMVNGSV 190

  Fly   193 LIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKP 257
            ....|.....|.|.|..:..| |.....| |:::...|.||..|::......:.....|.|...|
Zfish   191 SFHAVSREAAGQYQCYTSNSE-GNATHVT-RLKIIGPPVIIIPPSDTVLNMSQDAKLKCQAEADP 253

  Fly   258 VPEISWIRDATQLNVATADRFQVNPQT---GLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNV 319
             |.::::.....:::...|..:...:.   |.:.||.::.:|.|.|||:..|...|....:.:..
Zfish   254 -PNMTYVWQRQGVDIYHIDSLKSRIKVIVDGTLLISRLAPEDSGNYTCMPTNGLPVSPSASAVLT 317

  Fly   320 LVRP-QIYEL----YNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEP 379
            :..| |:.::    :..||.|.   ||.|..  |..|.::...|     ..:|:..|   :.:.|
Zfish   318 VQHPAQVIQMPKLTFLPTGMRG---AIVCPV--RAEPPLSHIDW-----IKDGKPLD---LGMYP 369

  Fly   380 NFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQ 444
            .:..   .|.|::.|:.......|:|.|...|......::...||        :.:.||.|....
Zfish   370 GWTL---ASDGSIVIATVNDDAAGVYICTPYNSFGTTGQSEPTTV--------ILQDPPSFKVSP 423

  Fly   445 RKAN---------LSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYS 500
            |...         :.|..:|.|...:.|...|...:.|:    .:.|.|   .||:||:::.:..
Zfish   424 RNEYRQDVGTMLVIPCQMVGNPAPKVNWRKIGAATRSLF----TLAGNG---SLILHPLSKDHQG 481

  Fly   501 GYKCIATN------------IHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELG 553
            .::|.::|            :.||:.|  .:....|....::|..|.:..    ||  |..|:
Zfish   482 EWECSSSNRVATVSIKTMVLVLGTSPH--AVSSVSVIPGTNQANVSWVAG----FD--GGYTQ-- 536

  Fly   554 LPILAYSVQYKEALNPDWSTAYNRSW------SPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWG 612
                .::|.||:.  ....|...:.|      |.::..:|..|.|.|||.|...|:|::|.|.:.
Zfish   537 ----TFTVWYKQV--SAGRTEEKQEWLSFSDLSTENSLLVTNLLPATEYQFSVMAQNKIGTGPFS 595

  Fly   613 ----VNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKY 673
                |....:.|..:..|.|..|.            |:..|:.|.|.|..|.....|||.:.::
Zfish   596 EIITVTTLDALPVVAKLEPPTNLS------------VNKSSEGFLLLWSAPHSKSPPIDSFVVQ- 647

  Fly   674 CPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGI 738
              .....|.|..|:...:..|    :...:..|..:..|.:.|.:.:....|.|:..|..:|.|:
Zfish   648 --SRLEGGEWDNLKEDISPAE----SKIFLPGLCKDCKYELRLLSQHGDQLSMPSPSISVSTFGM 706

  Fly   739 DVIQVAERQV-FSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRK--AKRSPSEIDDEA 800
            ::...:.|.: |.:..:.|: :|||.||..|:.|...|...:....:..|:  .|..|..:|..|
Zfish   707 NMRPASSRLLDFPNHIMAGV-MGGVGLLCLVLVLTLAIACFISYKRSRRRRQNIKDLPPAMDKNA 770

  Fly   801 KLGSLYGWRFPLPYCSGQLVKEPPPSPLPLPPPVKLGGS-----------------PMSTP---- 844
            .:      ..|......:|:   |..||..........|                 |.:.|
Zfish   771 SV------NIPDDTLKQRLL---PAHPLSTSSSASNHSSLDKFSHSDFHDLRQHHLPQANPPSHH 826

  Fly   845 -LDEKEPLRTPTGSIKQNSTIEF-----DGRF-VHSRSGE 877
             |.|.   .....|:...|::||     |||| ||...|:
Zfish   827 SLPES---HLQLSSLAPVSSVEFIHRGPDGRFVVHPGEGD 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/114 (18%)
		IG_like	144..226	CDD:214653	23/82 (28%)
		IGc2	152..209	CDD:197706	17/57 (30%)
		I-set	230..319	CDD:254352	19/91 (21%)
		IGc2	243..309	CDD:197706	14/68 (21%)
		IG_like	330..424	CDD:214653	19/93 (20%)
		IGc2	339..412	CDD:197706	15/72 (21%)
		Ig	447..518	CDD:143165	17/91 (19%)
		fn3	534..611	CDD:278470	22/82 (27%)
		FN3	640..735	CDD:238020	19/94 (20%)
igsf9a	XP_005155702.1	IG_like	27..110	CDD:214653	18/90 (20%)
		Ig	35..111	CDD:299845	17/83 (20%)
		I-set	140..221	CDD:254352	24/85 (28%)
		IGc2	151..212	CDD:197706	18/63 (29%)
		Ig	233..318	CDD:299845	15/85 (18%)
		I-set	233..318	CDD:254352	15/85 (18%)
		Ig	<349..402	CDD:299845	12/63 (19%)
		IG_like	423..502	CDD:214653	15/85 (18%)
		Ig	435..498	CDD:143165	14/69 (20%)
		FN3	507..602	CDD:238020	26/110 (24%)
		fn3	614..696	CDD:278470	19/100 (19%)
		PHA02666	1105..>1312	CDD:222914
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900