DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and sdk1b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_017211454.1	Gene:	sdk1b / 555553	ZFINID:	ZDB-GENE-090311-17	Length:	2292	Species:	Danio rerio

Alignment Length:	823	Identity:	199/823 - (24%)
Similarity:	301/823 - (36%)	Gaps:	173/823 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPPNSVGVFLALLLCSCSLIELTRAQSPI--LEIYPKQEVQRKPV--GKPLILTCRPTV---PEP 61
            |.....||:...:......:..|||...:  ::.:.:.| |||.|  |:..:|. .|.|   |.|
Zfish   224 LKREDAGVYQCAVRNRMGALIQTRADVRVAYMDNFAELE-QRKTVSQGRAAVLN-PPAVTSFPRP 286

  Fly    62 SLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEIL 126
            .:.    |..:....|   ||.|     ...||..:   |::.|.:....|:||..|........
Zfish   287 QVT----WFRDGVKII---PNHR-----VAITLDNQ---LVVLSTAAADAGRYYVQAVNERNGEN 336

  Fly   127 EKGVTIKTYVAITWTN--------------------APENQYPTLG-QDYVVMCEVKADPNPTID 170
            :...:|...:||...|                    ||:|.....| .:..:.|...|   .::|
Zfish   337 KTSPSIYLSIAINKRNRGSLADVIAPAELVAPVIVIAPKNTSVVAGASEATLECVANA---RSLD 398

  Fly   171 -----WLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGE-LLERTIRVEVFIQ 229
                 |.|||..:....|.:   ...|:|.|...:|.|:|.|.|.:..:.: ..|....:.|...
Zfish   399 RLQVFWKRNGVRLTAGVDSF---GRRLVISNPTSADGGLYVCEATLRNSSQKSTEAKAYLSVLES 460

  Fly   230 PEIISLPTNLEAVE-GKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVS 293
            |...|.|......| .|.....|.|:|.|.|::.|.:||..|:.....|:::...:.::.:..:.
Zfish   461 PHFTSKPKRYMIAEVEKNVELQCHAKGVPTPKLEWFKDAIPLSTLNNSRYKLTTSSMVLQVRRIQ 525

  Fly   294 QDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYEL--YNVTGARTKEIAITCRAKGRPAPAITFR 356
            .||.|.:.|.|:|.||.:...|.|.:.....::..  .::|.........||...|.|.|||.:|
Zfish   526 PDDAGIFQCFAENTAGEIQAHTNLVITSMSPLFTTPPSDITVTDGTSAVFTCDTSGAPKPAIVWR 590

  Fly   357 RWGTQEEYTNGQQDDDPRI-ILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTG 420
            : |:|...:...|  .||. :||          :|.|:|.....||.|.|.|:|.|.......|.
Zfish   591 K-GSQVLASGSVQ--TPRFTLLE----------SGGLQILPIMPSDAGNYTCLASNTEGLVNATV 642

  Fly   421 HITVEFAPDFSHMKELPPVFSWEQR-----KANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKI 480
            .:||......|    .||.   :||     .|.|.|.|...|..|:.:.|. :..|.|      .
Zfish   643 ALTVLSRTFIS----TPPE---DQRVIKGTTAVLHCAATHDPRVTVRYSWK-KGTKPL------S 693

  Fly   481 VGTGPRSDLIVHPV-TRQYYSG----YKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATT 540
            |.||.|..:....: ..|.:||    |.|...:..|......:|:...:|.     .|..|....
Zfish   694 VSTGGRVSMKEGSLQISQTWSGDIGDYTCRVISPAGNDSKSARLEVIELPH-----SPRNLQVAL 753

  Fly   541 MTFDIR-----------GPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPD-SPYIVEGLRPQ 593
            ...|.|           |.|     |:|.|.:::.|..:| |. .|....||. :..:|.||.|.
Zfish   754 NETDSRTVLLSWVRPFDGNS-----PLLHYIIEFSENNSP-WK-VYMDDVSPTLASLLVIGLTPA 811

  Fly   594 TEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEP--KPLHNPVQHDKEEPVVVSPYSDHFELRW 656
            ..|.||..|.||||.|.:..    .|.|....|||  .|..|.|...:....::        ::|
Zfish   812 RTYQFRVCAVNQVGRGQYSA----ETNRLMLREEPPSAPPKNIVASGRTNQSIM--------VQW 864

  Fly   657 GVPAD---NG---EPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQ-LVGN----T 710
            ..|.:   ||   ..:.||::...||               ..::...||.|:.. |:|.    |
Zfish   865 QPPPEPQLNGVLRGYVLRYRLAGLPG---------------EFQLKNITSAEINYCLIGELIIWT 914

  Fly   711 YYRIELKAHNAIG---YSSPASIIMKTTRGI------DVIQVA 744
            .|.|::.|:...|   ||..|:  ..|.:|:      ||..||
Zfish   915 QYEIQVAAYTGAGLGVYSQSAT--EYTLQGVPTAPPQDVEAVA 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/98 (24%)
		IG_like	144..226	CDD:214653	20/88 (23%)
		IGc2	152..209	CDD:197706	16/62 (26%)
		I-set	230..319	CDD:254352	25/89 (28%)
		IGc2	243..309	CDD:197706	18/66 (27%)
		IG_like	330..424	CDD:214653	27/94 (29%)
		IGc2	339..412	CDD:197706	24/73 (33%)
		Ig	447..518	CDD:143165	19/75 (25%)
		fn3	534..611	CDD:278470	27/88 (31%)
		FN3	640..735	CDD:238020	21/108 (19%)
sdk1b	XP_017211454.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910