DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and tutl

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	193/935 - (20%)
Similarity:	317/935 - (33%)	Gaps:	257/935 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GELPPNSVGVFLALLLCSCSLIELTRAQSPILEIYPKQEVQRKPV-GKPLILTCRPTVPEPSLVA 65
            |..|..::.|...:|:   ||:.|....:....| |:..|....: |:.:|..|....|....|.
  Fly   101 GSTPTPTIQVLQFVLV---SLLALLAKNAQAHNI-PEDAVHITAILGEGVIFNCHVEFPNDHPVP 161

  Fly    66 -DLQW--KDNRNNTILP------------KPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYY 115
             .|||  |.:...:.||            :...:.:....::..|..|.:|.:|::.....|.|.
  Fly   162 YVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYE 226

  Fly   116 CTASYANTEILEKGVTIKTYVAITWTN-----------APEN-QYPTLGQDYVVMCEVKADPNPT 168
            |...:.|.:       .|.:...||.:           .||: .|..||...::.|:....|.|.
  Fly   227 CKVVFLNRD-------PKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPE 284

  Fly   169 IDWLRNGDPIRTT------NDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGE-LLERTIRVEV 226
            |.|.::.:|:..:      ||     ...|.|..::..|.|.|||   :...|| .:..|.||.:
  Fly   285 ILWYKDANPVDPSPTVGIFND-----GTELRISTIRHEDIGEYTC---IARNGEGQVSHTARVII 341

  Fly   227 FIQPEIISLPTNLEAVEGKPFAANCTARGKP-VPEISWIRDATQLNVATADRFQVN-PQTGLVTI 289
            .....|:..|||...:||:....:|.|:..| ...:.|.|:.:.:....|...:|. .:.|.:.|
  Fly   342 AGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLII 406

  Fly   290 SSVSQDDYGTYTCLAKNRAGVVDQKT---------KLNVLVRPQI-YELYNVTGARTKEIAITCR 344
            :.:..||.|.|.|...|  |:.|.::         ...|...|.: |..:.:.|      .:.|.
  Fly   407 NPIKPDDSGQYLCEVTN--GIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAG------VVQCY 463

  Fly   345 AKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIA 409
            .|.  :|.:.:..|...:......|..|  |::..|         |:|..:.......|.|.|..
  Fly   464 IKS--SPQLQYVTWTKDKRLLEPYQMKD--IVVMAN---------GSLLFTRVNEEHQGQYACTP 515

  Fly   410 RNKGADAYKTGHITVEFAPDFSHMKELPPVFSWE-----QRK----ANLSCLAM---GIPNATIE 462
            .|....|..:|.:.|        :...||.|:.|     |||    ..:.|.|:   |....||:
  Fly   516 YNAQGTAGASGVMDV--------LVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIK 572

  Fly   463 W-HWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATN------------IHGTAE 514
            | ...|.::.:.....:||.|    .::.:..:.|:.:..|:|:.:|            |.||..
  Fly   573 WQRQEGEQLTESQRNRIKISG----GNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQP 633

  Fly   515 HDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPI-------------LAYSVQYKEA 566
            |                         ..::|.|.:||..:.:             ..|::.::||
  Fly   634 H-------------------------APYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREA 673

  Fly   567 LNPDWSTAYNRSWSP--DSPYIVEGLRPQTEYSFRFAARNQVGLGNWG----VNQQQSTPRRSAP 625
            ...||.|.   |.:|  .:...:.||...|.|.|:...||.:|.|...    |...:..|  :||
  Fly   674 GVNDWQTI---SVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAP--AAP 733

  Fly   626 EEPKPLHNP--------------------------------------VQHDKEEP---VVVSPYS 649
            ...|....|                                      |:..|..|   |.|:..|
  Fly   734 RNVKAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVS 798

  Fly   650 DHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVM-ETTSFEMTQLVGNTYYR 713
            :.|.:.|..|.:....:..|.|||    :....|..|    |..::. |.|.:.:..|||...|.
  Fly   799 NGFLITWQSPLERAHIVKFYTIKY----RTDAQWKTL----NRGQIRPEETQYLVKNLVGGRTYY 855

  Fly   714 IELKAHNAIGYSS--------PASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVD 770
            ..:.|::...|.|        ||.:..|                   ||....:||:|..:..:.
  Fly   856 FRVLANSEKSYESSDEVKFPVPARVKHK-------------------AITAGVVGGILFFIVAII 901

  Fly   771 LLCCITVHMGVMATMCRKAKRSPSE 795
            |..|       ...:|.|.||...|
  Fly   902 LSVC-------AVKICNKRKRRKQE 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/109 (18%)
		IG_like	144..226	CDD:214653	25/89 (28%)
		IGc2	152..209	CDD:197706	16/62 (26%)
		I-set	230..319	CDD:254352	23/99 (23%)
		IGc2	243..309	CDD:197706	17/67 (25%)
		IG_like	330..424	CDD:214653	17/93 (18%)
		IGc2	339..412	CDD:197706	13/72 (18%)
		Ig	447..518	CDD:143165	18/86 (21%)
		fn3	534..611	CDD:278470	21/91 (23%)
		FN3	640..735	CDD:238020	26/106 (25%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	22/119 (18%)
		IG_like	137..229	CDD:214653	18/91 (20%)
		I-set	253..341	CDD:254352	25/95 (26%)
		IGc2	268..331	CDD:197706	17/70 (24%)
		I-set	346..437	CDD:254352	23/92 (25%)
		Ig	349..437	CDD:299845	22/89 (25%)
		Ig	459..530	CDD:299845	16/83 (19%)
		IG_like	549..628	CDD:214653	15/82 (18%)
		IGc2	551..617	CDD:197706	14/69 (20%)
		FN3	633..725	CDD:238020	23/119 (19%)
		FN3	786..874	CDD:238020	23/95 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840