DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and negr1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	325	Identity:	79/325 - (24%)
Similarity:	128/325 - (39%)	Gaps:	61/325 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 SWIRDATQLNVATADRFQVNPQTGLVT-----------ISSVSQDDYGTYTCLAKNRAGVVDQKT 315
            :|: :.:.:..|..|::..:|:..:|:           |..|...|.|.|||..::...:..:..
Zfish    69 AWL-NRSSIIYAGNDKWSGDPRVSIVSNVGDKHEYSLQIQKVDVTDEGVYTCSIQSERNLHPKLI 132

  Fly   316 KLNVLVRPQIYEL-YNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEP 379
            :|.|.|.|:||:: .::|......:::.|.|.|:|.|.|::|.                   :.|
Zfish   133 QLIVKVPPKIYDISSDITVNEGSNVSLICAASGKPEPKISWRH-------------------ISP 178

  Fly   380 NFDEERGESTGTLRISNAERSDDGLYQCIARNKGADA-YKTGHITVEFAPDFSHMKE--LPPVFS 441
            :  ..:.||...|.|:...|...|.|:|.|.|..|.. .||..:||.|.|....||.  :.|
Zfish   179 S--ARKYESGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPAIHEMKSHGVRP--- 238

  Fly   442 WEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIA 506
              .:.|.|.|.|..:|:...||:...::|.  ....:.|.....||.|.|..:|:..|..|.|:|
Zfish   239 --GQVALLRCEAAAVPSPVFEWYKGEKRIN--MGQGIVINNLSSRSVLTVKNMTQDRYGNYTCVA 299

  Fly   507 TNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDW 571
            .|..|||...:.|.....|              |.|..:..|::.   |.:..|....|.|...|
Zfish   300 VNRLGTANASVPLNPIIEP--------------TTTSAVSSPASN---PAMYGSTGGAEVLLACW 347

Fly 572 571
Zfish 348 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653
		IGc2	152..209	CDD:197706
		I-set	230..319	CDD:254352	13/67 (19%)
		IGc2	243..309	CDD:197706	12/57 (21%)
		IG_like	330..424	CDD:214653	22/94 (23%)
		IGc2	339..412	CDD:197706	17/72 (24%)
		Ig	447..518	CDD:143165	22/70 (31%)
		fn3	534..611	CDD:278470	8/38 (21%)
		FN3	640..735	CDD:238020
negr1	XP_009300786.1	Ig	42..121	CDD:299845	12/52 (23%)
		IG_like	44..136	CDD:214653	13/67 (19%)
		I-set	140..222	CDD:254352	25/102 (25%)
		IGc2	153..208	CDD:197706	17/75 (23%)
		IG_like	236..312	CDD:214653	23/82 (28%)
		IGc2	238..304	CDD:197706	20/72 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810