DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and robo2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	184/821 - (22%)
Similarity:	299/821 - (36%)	Gaps:	177/821 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLCSCSLIELT-----RAQSPILEIYPKQEVQRKPVGKPLILTCRPT-VPEPSLVADLQW-KDN 72
            |||....|..||     :.::|.:..:|....  .|...|....|:.. .|.|:    :|| ||.
  Fly    70 LLLLLAGLNGLTQVGALKGENPRIIEHPMDTT--VPKNDPFTFNCQAEGNPTPT----IQWFKDG 128

  Fly    73 RNNTILPKPNGRNQPPMYTET------LPGESLALM--ITSLSVEMGGKYYCTASYANTEILEKG 129
            |.              :.|:|      ||...|..:  |.|......|.|:|.|.........:.
  Fly   129 RE--------------LKTDTGSHRIMLPAGGLFFLKVIHSRRESDAGTYWCEAKNEFGVARSRN 179

  Fly   130 VTIK-TYVAITWTNAPENQYPTLGQDYVVMCEV-KADPNPTIDWLRNGDPIRTTNDK--YVVQTN 190
            .|:: .::...:...|.|.....|:..::.|.. :..|.|.|.|.:||..:....:|  .:|...
  Fly   180 ATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGG 244

  Fly   191 GLLIRNVQESDEGIYTCRAA-VIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTAR 254
            .|.|:..::||:|.|.|... |:.|.|  ..|..::|.::|.:|..|.|..||.|......|...
  Fly   245 NLAIQEARQSDDGRYQCVVKNVVGTRE--SATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIG 307

  Fly   255 GKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNV 319
            |.|:|::.|.|.|:..|:... |..|.....| .:..|:.:|.|.|||.|.|..|.:.....|.|
  Fly   308 GDPLPDVLWRRTASGGNMPLR-RVHVLEDRSL-KLDDVTLEDMGEYTCEADNAVGGITATGILTV 370

  Fly   320 ------LVRP--QIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRII 376
                  ::||  |:.|:.:       |:...|:|.|.|.|.:.:...|.......|.:|....:.
  Fly   371 HAPPKFVIRPKNQLVEIGD-------EVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVT 428

  Fly   377 LEPNFDEERGESTGTLRISNAERSDDG-LYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVF 440
            |.|       |....|.|:...|.|.| :..|.|.|      ..|.::...........||||..
  Fly   429 LTP-------EGRSVLSIARFAREDSGKVVTCNALN------AVGSVSSRTVVSVDTQFELPPPI 480

  Fly   441 SWEQRKAN----------LSCLAMGIPNATIEWHWNGRKIKDLYD---TNLKIVGTGPRSDLIVH 492
            . ||...|          |.|..:|.|...:.|:.:|..| |:.:   .||...|....|||..|
  Fly   481 I-EQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPI-DVQEHERRNLSDAGALTISDLQRH 543

  Fly   493 PVTRQYYSGYKCIATNIHGTAE----------HDMQLKEARVPD------------FVSEAKPSQ 535
                :....|.|:|:|.:|.:.          .:..:|..|.|:            .|.:.:.|.
  Fly   544 ----EDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSV 604

  Fly   536 LTATTMTFDIRGPSTELGLPILAYSVQ-YKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFR 599
            ..:.|.:..:.|.|      ::.|.:: :.:.....|.....|  ..::.:...||.|...|.|.
  Fly   605 TLSWTRSNKVGGSS------LVGYVIEMFGKNETDGWVAVGTR--VQNTTFTQTGLLPGVNYFFL 661

  Fly   600 FAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGE 664
            ..|.|..||                 ..|.|:        .||:.|.  :.:|        ::|.
  Fly   662 IRAENSHGL-----------------SLPSPM--------SEPITVG--TRYF--------NSGL 691

  Fly   665 PIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMT-QLVGNTY----YRIELKAHNAIGY 724
            .:...:...     :||...||.|:    .|:::||.::| |::...|    |....:..|.| .
  Fly   692 DLSEARASL-----LSGDVVELSNA----SVVDSTSMKLTWQIINGKYVEGFYVYARQLPNPI-V 746

  Fly   725 SSPASIIMKTTRGIDVIQVAERQVFSSAAIV----GIAIGG 761
            ::||.:...|...:.....:.....|::|::    .||..|
  Fly   747 NNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAG 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	22/103 (21%)
		IG_like	144..226	CDD:214653	23/85 (27%)
		IGc2	152..209	CDD:197706	17/59 (29%)
		I-set	230..319	CDD:254352	28/88 (32%)
		IGc2	243..309	CDD:197706	20/65 (31%)
		IG_like	330..424	CDD:214653	21/94 (22%)
		IGc2	339..412	CDD:197706	18/73 (25%)
		Ig	447..518	CDD:143165	21/93 (23%)
		fn3	534..611	CDD:278470	16/77 (21%)
		FN3	640..735	CDD:238020	21/99 (21%)
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	24/114 (21%)
		I-set	91..184	CDD:254352	24/112 (21%)
		I-set	190..279	CDD:254352	23/90 (26%)
		Ig2_Robo	193..279	CDD:143201	23/87 (26%)
		I-set	283..370	CDD:254352	28/88 (32%)
		Ig	300..370	CDD:299845	21/71 (30%)
		Ig	388..>457	CDD:299845	19/82 (23%)
		I-set	479..561	CDD:254352	23/87 (26%)
		Ig	496..561	CDD:143165	20/69 (29%)
		FN3	588..681	CDD:238020	21/125 (17%)
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840