DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and LSAMP

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	363	Identity:	89/363 - (24%)
Similarity:	141/363 - (38%)	Gaps:	66/363 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 IQPE-----------IISLPT--------------NLEAVEGKPFAANCTARGKPVPEISWIRDA 267
            :||:           :..|||              |:...:|......|....|. .:::|: :.
Human     5 VQPDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKN-SKVAWL-NR 67

  Fly   268 TQLNVATADRFQVNPQTGL---------VTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRP 323
            :.:..|..|::.::|:..|         :.|..|...|.|:|||..:.:......:..|.|.|.|
Human    68 SGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPP 132

  Fly   324 QIYEL-YNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGE 387
            :|..: .:||......:.:.|.|.|||.|.||:|.                   |.|...|..||
Human   133 KISNISSDVTVNEGSNVTLVCMANGRPEPVITWRH-------------------LTPTGREFEGE 178

  Fly   388 STGTLRISNAERSDDGLYQCIARNKGADA-YKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSC 451
            .. .|.|....|...|.|:|.|.|:.:.| .|...:||.:.|..:..|.......   |:|:|.|
Human   179 EE-YLEILGITREQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSNEATTG---RQASLKC 239

  Fly   452 LAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHD 516
            .|..:|....||:.:..:|...  ..|:|..|..:|.|.|..||.::|..|.|:|.|..|.....
Human   240 EASAVPAPDFEWYRDDTRINSA--NGLEIKSTEGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302

  Fly   517 MQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGL 554
            :.|.:..:|..   ..|.|...||:.|..:||.:..|:
Human   303 LVLFKRVLPTI---PHPIQEIGTTVHFKQKGPGSVRGI 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653
		IGc2	152..209	CDD:197706
		I-set	230..319	CDD:254352	21/122 (17%)
		IGc2	243..309	CDD:197706	15/74 (20%)
		IG_like	330..424	CDD:214653	26/94 (28%)
		IGc2	339..412	CDD:197706	21/72 (29%)
		Ig	447..518	CDD:143165	22/70 (31%)
		fn3	534..611	CDD:278470	7/21 (33%)
		FN3	640..735	CDD:238020
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	17/91 (19%)
		Ig	132..215	CDD:386229	28/102 (27%)
		Ig_3	219..294	CDD:372822	23/79 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810