DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and dscamb

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	766	Identity:	191/766 - (24%)
Similarity:	314/766 - (40%)	Gaps:	113/766 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KPLILTCR-PTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLA-LMITSLSVEM 110
            :|:.|.|. ...|.|::...|.     ::.::...|.|....:.||   |..|: |.::...|..
Zfish   422 EPISLVCHVKGTPLPTVTWTLD-----DDPVIKDSNHRMDRIITTE---GHVLSYLNVSHTQVSD 478

  Fly   111 GGKYYCTA-SYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRN 174
            ||.|.||. :.|.:...:..:.::...:|   ...:|.....|:|..:.|.:...|..:|.|.::
Zfish   479 GGVYRCTCNNSAGSVSYQARINVRGPASI---RPMKNVTAIAGRDTYIHCRIIGYPYYSIKWYKD 540

  Fly   175 GDPIRTTNDKYVVQTNGLL-IRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTN 238
            .:.:...:.:...:.||.| :.|||.||||.||| ..:::..:.:.|::.|.|.: |.:|....:
Zfish   541 SNLLPFNHRQRAFENNGTLKLSNVQNSDEGEYTC-YVLVDPEKQIHRSVHVTVKV-PPLIQHSDS 603

  Fly   239 LEAVEGKPFAANCTARGKPVP-EISWIRDATQLNVA---TADRFQVNPQTGLVTISSVSQDDYGT 299
            ..|..|:.....|......:| .|:|.:|...:|.:   |.|....   |..:.||::|:...|:
Zfish   604 QSASIGQRVFIPCVVISGDLPMSITWHKDGRPINASLGVTIDNIDF---TSSLRISNLSEIHNGS 665

  Fly   300 YTCLAKNRAGVVDQKTKLNVLVRPQIYELY--NVTGARTKEIAITCRAKGRPAPAITFRRWGTQE 362
            |||:|:|.|..|:...:|.|.|.|. :|:.  :..|...|.:.:.|.|||.|.|.|.   |...:
Zfish   666 YTCIARNEAAAVEHSIQLIVKVPPH-FEVQPKDQDGIYGKSVTLNCSAKGNPIPTIV---WNHSK 726

  Fly   363 -----EYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQC-IARNKGADAYKTGH 421
                 ::.....:...|:.|..|         |:|.|.:....|.|.|.| ::.:.|||..|:.:
Zfish   727 GAGVPQFQPIALNSGSRVQLLEN---------GSLLIKHVLEEDAGFYLCKVSNDVGADISKSMY 782

  Fly   422 ITVEFAPDFSHMKELPPVFSWEQ-RKANLSCLAMGIPNATIEWHWNGRKIK-DL--YDTNLKIVG 482
            :||:..   :.:...|.....|| ....:||.|.|.....:.|......|. |:  |...:|.||
Zfish   783 LTVKIP---AMITSYPNTTRAEQGHMTEMSCTAHGEKPIKVRWEKESHIINPDMSRYVVTVKEVG 844

  Fly   483 TGPRSDL-IVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FVSEAKPSQLTAT-TM 541
            ....|.| |:|.| |:....:.|||.|.:|..:..:||.....||    .:.|.|...:... ||
Zfish   845 DEVISTLQILHTV-REDSGFFSCIAINSYGEDKGIIQLIVQDRPDPPEVEIREVKDRTIALRWTM 908

  Fly   542 TFDIRGPSTELGLPILAYSVQYKEALNPDW-STAYNRSWSP--DSPYIVEGLRPQTEYSFRFAAR 603
            .||  |.|     ||..|.:.||.. :..| |:...:..||  :...|:| |.|.:.|:.|..|:
Zfish   909 GFD--GNS-----PITGYDINYKNK-SASWASSQMTKDVSPQLNQATIIE-LHPASTYNIRMFAK 964

  Fly   604 NQVGLGNWGVNQQQSTPRR-------SAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPAD 661
            ||:|         :|.|..       .||.:..|....::....:.:.|:....|..|:.|:
Zfish   965 NQIG---------ESRPSNELTITTDEAPPDGAPQDVQLEAISSQGIKVTWKPPHKHLQNGL--- 1017

  Fly   662 NGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFE---MTQLVGNTYYRIELKAHNAIG 723
                |..||:.|    :..||....:  .||:.|..|...|   :..|...|.|.:.::|.|..|
Zfish  1018 ----IRSYQVCY----REFGTGGSPQ--YNTINVDTTGDIETLTLDNLKKYTQYEVRVQAANRAG 1072

  Fly   724 YSSPASIIMKTT----------RGIDVIQVAERQVFSSAAIVGIAIGGVLL 764
            ....:..|..||          ..:......|....|.:|:...|:.|:||
Zfish  1073 MGPTSEEITITTLEDVPSRPPENVVTTATTPETISLSWSALPKEALNGMLL 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/87 (23%)
		IG_like	144..226	CDD:214653	22/82 (27%)
		IGc2	152..209	CDD:197706	19/57 (33%)
		I-set	230..319	CDD:254352	25/92 (27%)
		IGc2	243..309	CDD:197706	19/69 (28%)
		IG_like	330..424	CDD:214653	24/99 (24%)
		IGc2	339..412	CDD:197706	18/78 (23%)
		Ig	447..518	CDD:143165	22/74 (30%)
		fn3	534..611	CDD:278470	25/80 (31%)
		FN3	640..735	CDD:238020	22/97 (23%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352
		I-set	225..310	CDD:254352
		IGc2	239..300	CDD:197706
		IG_like	320..400	CDD:214653
		IGc2	328..391	CDD:197706
		IG_like	417..501	CDD:214653	20/86 (23%)
		Ig	424..498	CDD:143165	19/81 (23%)
		IG_like	511..592	CDD:214653	22/81 (27%)
		IGc2	518..576	CDD:197706	19/58 (33%)
		I-set	595..685	CDD:254352	25/92 (27%)
		Ig	612..682	CDD:143165	20/72 (28%)
		I-set	689..785	CDD:254352	26/108 (24%)
		Ig7_DSCAM	706..785	CDD:143211	22/90 (24%)
		IG_like	795..883	CDD:214653	27/88 (31%)
		Ig	803..890	CDD:299845	26/87 (30%)
		FN3	887..980	CDD:238020	31/110 (28%)
		FN3	987..1084	CDD:238020	23/109 (21%)
		FN3	1092..1185	CDD:238020	7/32 (22%)
		FN3	1190..1279	CDD:238020
		IGc2	1302..1367	CDD:197706
		FN3	1398..1471	CDD:238020
		FN3	1485..1557	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900