DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fas2 and Igdcc4

DIOPT Version :10

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:XP_038937673.1 Gene:Igdcc4 / 363081 RGDID:1310919 Length:1345 Species:Rattus norvegicus


Alignment Length:997 Identity:209/997 - (20%)
Similarity:312/997 - (31%) Gaps:365/997 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VPEPSLVADLQW-KDNRNNTILPK----PNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCT 117
            :|.|.:.    | ||....|..|:    |||                .|.|..:.....|.|.|.
  Rat   261 LPAPIIT----WEKDQVTVTEEPRLITLPNG----------------VLQILDVQDSDAGSYRCV 305

  Fly   118 ASYANTEILEKGVTIKTYVA----------ITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWL 172
            |:.:..:...:...:...:.          :....||||.....||..|:.|...|||.|.:.|:
  Rat   306 ATNSARQRFSQEALLSVALRGSLEATRGQDVVIVAAPENTTVVSGQSVVLECVASADPTPFVSWV 370

  Fly   173 R-NGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLP 236
            | :|.||.|  |..|:....|||.:.|....|:|.|||....|.:.......:.|...|.|...|
  Rat   371 RQDGKPIST--DVIVLGRTNLLIASAQPRHSGVYVCRANKPRTRDFATAAAELRVLAAPAISQAP 433

  Fly   237 TNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYT 301
            ..|...........|.|.|:|.|.:.|:.|...|.  ...|.:|....|.:.|:.:...|.|.|.
  Rat   434 EALSRTRASTARFVCRASGEPRPTLHWLHDGAPLR--PNGRVKVQGGGGSLVITQIGLQDSGYYQ 496

  Fly   302 CLAKNRAGVVDQKTKLNVLV--------------------------RPQI--------------- 325
            |:|:|.||.......|.|:|                          ||::               
  Rat   497 CVAENSAGTACAAAPLAVVVREGLPSAPTRVKATPLSSSAVLVAWERPELHSEQIIGFSLHYQKA 561

  Fly   326 -----------------------------YELYNVT-----GARTKEIAITCRAKGRP--APAIT 354
                                         ||.|.|.     .:||...|:.......|  ||.::
  Rat   562 RGVDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSSPALVHTLDDVPSAAPQLS 626

  Fly   355 FRRWGTQE----------------------EYTNGQQD---------DDPRII---LEPNFDEER 385
            .......:                      ||.:|::|         ::.::.   |:||     
  Rat   627 LSSPNPSDIRVAWLPLPSSLSNGQVVKYKIEYGSGKEDQVFSTEVPGNETQLTLNSLQPN----- 686

  Fly   386 GESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPD----FSHMKELPPVFSWEQRK 446
              ....:|||....:..|:.....:::...|:...|  |.|||.    .:.|:.|  |.||:.. 
  Rat   687 --KVYRVRISAGTGAGYGVPSQWMQHRTPGAHNQSH--VPFAPAELKVRAKMESL--VVSWQPP- 744

  Fly   447 ANLSCLAMGIPNAT----IEWHWNGRKIKDLYDTNLKIVGT----------GPRSDLI--VHPV- 494
                      |:.|    .:.:|             :.|||          |.|.|..  |.|| 
  Rat   745 ----------PHPTQISGYKLYW-------------REVGTEEEADGDRPPGGRGDQAWDVGPVR 786

  Fly   495 ----TRQY----------YSGYKCIATNIHG---TAEHDMQLKEARVPDFVSEAKPSQLTATTMT 542
                .:||          |. .|.:|.|.|.   .|....:.::|..||.     |.|       
  Rat   787 LKKKVKQYELTQLVPGRLYE-VKLVAFNKHEDGYAAVWKGKTEKAPTPDL-----PIQ------- 838

  Fly   543 FDIRGP-------------STELGL----------PILAYSVQYKE--ALNPDWSTAYNRSWSPD 582
               |||             ||.:.|          .|:.|:|::..  ..|....|.|.   |..
  Rat   839 ---RGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFGPWGLRNASLVTYYT---SSG 897

  Fly   583 SPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSP 647
            ...::.||:|.|:|.|...:......|.:|...::||    .|:.|.   .|....:..|:..|.
  Rat   898 EDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERST----LPDRPS---TPPSDLRLSPLTPST 955

  Fly   648 YSDHFELRWGVPAD-NGEPIDRYQIKYCPG-VKISGTWTELENSCNTVEVMETTSFEMTQLVGNT 710
                ..|.|..|.: |||.:: |.|.|... .:....||.|....|..      |.|:..|..:|
  Rat   956 ----VRLHWCPPTEPNGEIVE-YLILYSNNHTQPEHQWTLLTTEGNIF------SAEVHGLESDT 1009

  Fly   711 YYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSA----AIVGIAIGGVLLLLFVVDL 771
            .|..::.|...:| ..|.|.:.      |||.:.|  .||.:    ::.||.:|..|      .|
  Rat  1010 RYFFKMGARTEVG-PGPFSRLQ------DVITLQE--TFSDSLDVHSVTGIIVGVCL------GL 1059

  Fly   772 LCCITVHMGVMATMCRKAKRS-------------------------------------------- 792
            ||       ::|.||...:||                                            
  Rat  1060 LC-------LLACMCAGLRRSSHREALPGLSSTATAGNPALYSRARLGPPSVPAAHELESLVHPR 1117

  Fly   793 -------PSEIDDEAKLGSLYG 807
                   ||:::|:||:.||.|
  Rat  1118 PQDWSPPPSDVEDKAKVHSLMG 1139

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 Ig 33..121 CDD:472250 16/67 (24%)
Ig strand B 50..54 CDD:409353
Ig strand C 66..70 CDD:409353 1/4 (25%)
Ig strand E 99..103 CDD:409353 1/3 (33%)
Ig strand F 113..118 CDD:409353 2/4 (50%)
Ig 139..209 CDD:472250 27/70 (39%)
Ig strand B 156..159 CDD:409353 1/2 (50%)
Ig strand C 168..172 CDD:409353 0/3 (0%)
Ig strand E 190..194 CDD:409353 1/3 (33%)
Ig strand F 204..209 CDD:409353 2/4 (50%)
IgI_4_MYLK-like 229..319 CDD:409568 25/89 (28%)
Ig strand A 229..232 CDD:409568 1/2 (50%)
Ig strand A' 238..241 CDD:409568 1/2 (50%)
Ig strand B 246..254 CDD:409568 1/7 (14%)
Ig strand C 260..264 CDD:409568 0/3 (0%)
Ig strand C' 267..270 CDD:409568 0/2 (0%)
Ig strand D 277..281 CDD:409568 1/3 (33%)
Ig strand E 285..290 CDD:409568 1/4 (25%)
Ig strand F 298..306 CDD:409568 4/7 (57%)
Ig strand G 309..319 CDD:409568 2/9 (22%)
IG_like 330..424 CDD:214653 20/134 (15%)
Ig strand B 339..343 CDD:409353 1/3 (33%)
Ig strand C 352..356 CDD:409353 0/3 (0%)
Ig strand E 388..394 CDD:409353 0/5 (0%)
Ig strand F 404..409 CDD:409353 0/4 (0%)
Ig 447..515 CDD:409353 20/101 (20%)
Ig strand B 447..451 CDD:409353 0/3 (0%)
Ig strand C 460..464 CDD:409353 1/7 (14%)
Ig strand E 487..491 CDD:409353 1/5 (20%)
Ig strand F 501..506 CDD:409353 1/4 (25%)
FN3 525..619 CDD:238020 25/118 (21%)
FN3 640..735 CDD:238020 24/96 (25%)
Igdcc4XP_038937673.1 Ig 131..223 CDD:472250
Ig strand B 144..148 CDD:409353
Ig strand C 160..164 CDD:409353
Ig strand E 182..186 CDD:409353
Ig strand F 210..215 CDD:409353
Ig_3 237..308 CDD:464046 16/66 (24%)
IG_like 342..423 CDD:214653 29/82 (35%)
Ig strand B 353..357 CDD:409353 1/3 (33%)
Ig strand C 366..370 CDD:409353 0/3 (0%)
Ig strand E 387..391 CDD:409353 1/3 (33%)
Ig strand F 401..406 CDD:409353 2/4 (50%)
Ig 442..514 CDD:472250 21/73 (29%)
Ig strand B 444..448 CDD:409353 0/3 (0%)
Ig strand C 457..461 CDD:409353 0/3 (0%)
Ig strand E 478..484 CDD:409353 1/5 (20%)
FN3 <494..>695 CDD:442628 30/207 (14%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 0/2 (0%)
fn3 724..818 CDD:394996 26/120 (22%)
FN3 842..934 CDD:238020 18/94 (19%)
FN3 942..1034 CDD:238020 27/109 (25%)
Blue background indicates that the domain is not in the aligned region.

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