DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	208/983 - (21%)
Similarity:	330/983 - (33%)	Gaps:	289/983 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YPKQEVQRKPV---GKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGE 97
            |.|.|..|..|   |..|:|||   :.|.|...:.:|..|...                  |...
  Rat    30 YFKTEPVRTQVHLEGNRLVLTC---MAEGSWPLEFKWLHNNRE------------------LTRF 73

  Fly    98 SL--ALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMC- 159
            ||  ..|||||.....|.|.|........:|::...::.....::....::|..:.|:..|:..
  Rat    74 SLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIKAP 138

  Fly   160 EVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLER---T 221
            .:.:.|.|.:.|.|:|..|..::...:...|.|:|.:....|.|.|..:|...:.|:....   |
  Rat   139 RISSFPRPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 203

  Fly   222 IRVEVF------IQPEIISLPTNLEAVEG-KPFAANCTARGKPVPE--ISWIRDATQLNVATADR 277
            :.||..      |.|.||..|.|...|.| ......|.|..:|:.:  |.|.:|...|:...:|
  Rat   204 LAVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDGALLSNGISD- 267

  Fly   278 FQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTK---LNVLVRPQIYE--LYNVTGARTK 337
                 ....:||::....|.|.|.|.|..|:..|...|:   |:||..||...  ..::|....|
  Rat   268 -----YNRRLTITNPMVSDAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEK 327

  Fly   338 EIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDD 402
            .:.|.|||||.|.|:||:.:              |..::........:..|.|.|:||.....|.
  Rat   328 VVDIPCRAKGVPPPSITWYK--------------DAALVEVGKLTRFKQRSDGGLQISGLLPDDT 378

  Fly   403 GLYQCIARNKGADAYKTGHITV-EFAPDFSHMKELPPVFSW--EQRKANLSCLAMGIPNATIEWH 464
            |:.||.|.|...:|..:.::.| ..||:.:.    .|:.|.  :.....|:|...|.|...|.|.
  Rat   379 GMVQCFAHNAAGEAQTSTYLAVTSIAPNITR----GPLDSTVIDGMSVVLACETSGAPRPAITWQ 439

  Fly   465 WNGRKIKDLYDTNLKIVGTG----PR------SDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQL 519
            ...|           |:.:|    ||      ..|::.|........|.|:|||..|..|....|
  Rat   440 KGER-----------ILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASADL 493

  Fly   520 ------KEARVPDFVSEAKPSQLTATT-MTFDIR------------------GP----------- 548
                  :..:.|...|..|.:|.:... :|.|.|                  .|
  Rat   494 VVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVWEKDGATLAVETNPRIRLDRNGSLH 558

  Fly   549 -----STELGL-----------------------------PILAYSVQYKEALNPDWSTAY---- 575
                 |.::|.                             |:...|...:.|:|..|:..:
  Rat   559 ISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTMERRAINLTWAKPFDGNS 623

  Fly   576 ------------NRSWS-------PDSPYI-VEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTP 620
                        |..|:       |::..: |:||.|...|.||..|.|.||.|.:    .:.|.
  Rat   624 PLMRYILEMSENNAPWTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVGKGQF----SKDTE 684

  Fly   621 RRSAPEEP--KPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEP--IDRYQIKYC-PGVKIS 680
            |.|.||||  .|..|.:...:....::        ::|..|.::.:.  :..|.|:|| .|:.:.
  Rat   685 RVSLPEEPPTAPPQNVIASGRTNQSIM--------IQWQPPPESHQNGILKGYIIRYCLAGLPVG 741

  Fly   681 GTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIG---YSS--------------PA 728
            ..:..:.::       :..:..:..|:..|.|.||:.|:|:.|   |||              |.
  Rat   742 YQFKNITDA-------DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPG 799

  Fly   729 SIIMKTT-----------------RGI---------------DVIQVAERQVFSSAAIVGIAIGG 761
            ::..:.|                 .||               :|..|..|..|..:..||...|.
  Rat   800 NVHAEATNSTAIRFTWNAPSPQFINGINQGYKLIAWEPTQEEEVTMVTARPNFQDSIHVGFVSGL 864

  Fly   762 VLLLLFVVDLLCCITVHMG-------------------------VMATMCRKAKRSPSEIDDEAK 801
            .....:...:||..|...|                         ::.|..:.:.:.|.|     |
  Rat   865 KKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPGE-----K 924

  Fly   802 LGSLYGWR 809
            .|.|.|:|
  Rat   925 NGILTGYR 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/98 (24%)
		IG_like	144..226	CDD:214653	19/85 (22%)
		IGc2	152..209	CDD:197706	14/57 (25%)
		I-set	230..319	CDD:254352	26/94 (28%)
		IGc2	243..309	CDD:197706	17/68 (25%)
		IG_like	330..424	CDD:214653	25/93 (27%)
		IGc2	339..412	CDD:197706	21/72 (29%)
		Ig	447..518	CDD:143165	20/80 (25%)
		fn3	534..611	CDD:278470	27/164 (16%)
		FN3	640..735	CDD:238020	19/114 (17%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653	21/89 (24%)
		IGc2	43..101	CDD:197706	20/78 (26%)
		IG_like	123..206	CDD:214653	18/82 (22%)
		Ig	135..191	CDD:299845	13/55 (24%)
		IG_like	225..307	CDD:214653	22/87 (25%)
		IGc2	236..289	CDD:197706	14/58 (24%)
		I-set	311..400	CDD:254352	27/102 (26%)
		Ig	329..397	CDD:143165	23/81 (28%)
		I-set	405..495	CDD:254352	24/104 (23%)
		Ig	419..495	CDD:299845	21/86 (24%)
		Ig	505..589	CDD:299845	10/83 (12%)
		IG_like	505..589	CDD:214653	10/83 (12%)
		FN3	593..684	CDD:238020	20/94 (21%)
		FN3	696..789	CDD:238020	20/107 (19%)
		FN3	797..893	CDD:238020	15/95 (16%)
		FN3	898..986	CDD:238020	8/40 (20%)
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900