DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and Dscam1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	195/761 - (25%)
Similarity:	300/761 - (39%)	Gaps:	161/761 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QEVQRKPVGKPLILTC----RPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESL 99
            ||...:| |..:.|.|    .||   |.:..:|..|...|       |.|.|...|. |:.|:.:
  Fly   440 QEETMEP-GPSVFLKCVAGGNPT---PEISWELDGKKIAN-------NDRYQVGQYV-TVNGDVV 492

  Fly   100 A-LMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKA 163
            : |.|||:....||.|.|.|. :...:.|....:..| .:.:....|.:....|:..:|.|.|..
  Fly   493 SYLNITSVHANDGGLYKCIAK-SKVGVAEHSAKLNVY-GLPYIRQMEKKAIVAGETLIVTCPVAG 555

  Fly   164 DPNPTIDWLRNGD--PIRTTNDKYVVQTNG-LLIRNVQ-ESDEGIYTCRAAVIETGELLERTIRV 224
            .|..:|.|.|:..  ||   |.|..|..|| |:|.||: .||:..||| .|..:.|.....::.|
  Fly   556 YPIDSIVWERDNRALPI---NRKQKVFPNGTLIIENVERNSDQATYTC-VAKNQEGYSARGSLEV 616

  Fly   225 EVFIQPEIISLPTNLEAVEGKPFAAN------------CTAR--GKPVPEISWIRDATQLNVATA 275
            :|.:.|:|:            |||..            |..:  .:|: ::.|   :.:.:....
  Fly   617 QVMVLPQIV------------PFAYEDLINMGDSIDLFCQIQKGDRPI-KVHW---SFERSAGDY 665

  Fly   276 DRFQVNPQ---------TGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQ-IYELYN 330
            ...||.||         |.:::|.|.|....|..||:|.|:||.......|.|.|.|: |.|..:
  Fly   666 GFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTD 730

  Fly   331 VTGARTKEIAITCRAKGRPAPAITFRR--WGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLR 393
            ...|:..:..:.|:|.|.|.|.:|:::  ..|..||.:.::.|:.|:       ||     |||.
  Fly   731 KAFAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV-------EE-----GTLH 783

  Fly   394 ISNAERSDDGLYQCIARNK-GADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIP 457
            :.|.:::::|.|.|.|.|. |:.......|:|:..|:|:  ::|....:.....|.|.|.|.|..
  Fly   784 VDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFT--EKLRNQTARRGEPAVLQCEAKGEK 846

  Fly   458 NATIEWHWNGRKI----KDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQ 518
            ...|.|:.|..::    .:.|....:|:.||..|.|.:....|...:.:.|:|||..|:.:..:.
  Fly   847 PIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASIN 911

  Fly   519 LKEARVPDFVSEAKPSQLTATTMTFDIRGPSTEL--------GLPILAYSVQYKEALNPDWSTAY 575
            :....||:.....|         ..|..|.|.:|        ..|:..|.:::|.:
  Fly   912 MIVQEVPEMPYALK---------VLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRS--------- 958

  Fly   576 NRSWSPDSPYIVEG---------LRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPL 631
            ..|||.....||.|         |.|.|.|:.|..|.|.:|      ..|.|........|..|.
  Fly   959 RASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIG------TSQSSEAVTIITAEEAPS 1017

  Fly   632 HNPVQHDKEEPVVVSPYSDHFELRWGVPAD---NGEPIDRYQIKYCPGVKISGTWTELENSCNTV 693
            ..| |:.|.|||    ......:.|..|..   |||.:.     |..|.|:|.|        |:.
  Fly  1018 GKP-QNIKVEPV----NQTTMRVTWKPPPRTEWNGEILG-----YYVGYKLSNT--------NSS 1064

  Fly   694 EVMETTSF----------EMTQLVGNTYYRIELKAHNAIGYSSPAS 729
            .|.||.:|          |:..|...|.|.:.::|.|.|| :.|.|
  Fly  1065 YVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIG-AGPLS 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	28/98 (29%)
		IG_like	144..226	CDD:214653	28/85 (33%)
		IGc2	152..209	CDD:197706	24/60 (40%)
		I-set	230..319	CDD:254352	24/111 (22%)
		IGc2	243..309	CDD:197706	19/88 (22%)
		IG_like	330..424	CDD:214653	25/96 (26%)
		IGc2	339..412	CDD:197706	21/74 (28%)
		Ig	447..518	CDD:143165	20/74 (27%)
		fn3	534..611	CDD:278470	21/93 (23%)
		FN3	640..735	CDD:238020	28/103 (27%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	28/99 (28%)
		IGc2	446..517	CDD:197706	25/83 (30%)
		I-set	533..618	CDD:254352	28/88 (32%)
		IGc2	544..607	CDD:197706	25/66 (38%)
		Ig	641..714	CDD:143165	18/76 (24%)
		IGc2	735..804	CDD:197706	22/80 (28%)
		I-set	819..914	CDD:254352	23/96 (24%)
		Ig	833..921	CDD:299845	22/87 (25%)
		FN3	918..1011	CDD:238020	25/116 (22%)
		FN3	1018..1116	CDD:238020	31/111 (28%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000