DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and IL1R1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_000868.1	Gene:	IL1R1 / 3554	HGNCID:	5993	Length:	569	Species:	Homo sapiens

Alignment Length:	366	Identity:	84/366 - (22%)
Similarity:	138/366 - (37%)	Gaps:	70/366 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNT 76
            |:|||:.|....:....:..|:.:....|:..:|        | |..|.........:||:
Human    10 FIALLISSLEADKCKEREEKIILVSSANEIDVRP--------C-PLNPNEHKGTITWYKDD---- 61

  Fly    77 ILPKPNGRNQPPMYTE---TLPGESLALMITSLSVEMGGKYYC---TASYA-NTEILEKGVTIKT 134
                    ::.|:.||   .:......|......||..|.|||   .:||. ..:|..|.|..:.
Human    62 --------SKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEP 118

  Fly   135 YVAITWTNAPENQYPTLGQDYVVMCE----VKADPN--PTIDWLRNGDPIRTTNDKYVVQTNGLL 193
            .:........:.:.|..| |..::|.    .|.:.|  |.:.|.::..|:...|..:....:.|:
Human   119 NLCYNAQAIFKQKLPVAG-DGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLI 182

  Fly   194 IRNVQESDEGIYTCRAAVIETGELLERTIRVEVFI--------QPEIISLPTN--LEAVEGKPFA 248
            :.||.|...|.|||.|:....|:....| ||..||        :|.|:| |.|  :|...|....
Human   183 VMNVAEKHRGNYTCHASYTYLGKQYPIT-RVIEFITLEENKPTRPVIVS-PANETMEVDLGSQIQ 245

  Fly   249 ANCTARGKPVPEISWIRDATQLN----VATADRFQV-NP----QTGLVTISSVSQDDYGTY---- 300
            ..|...|:......|..:.:.::    |...|.:.| ||    ::.|:|:.::|:.:...|
Human   246 LICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPF 310

  Fly   301 TCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKEIAI 341
            ||.|||..|:.....:|          :|.||..:...|.|
Human   311 TCFAKNTHGIDAAYIQL----------IYPVTNFQKHMIGI 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	22/100 (22%)
		IG_like	144..226	CDD:214653	23/87 (26%)
		IGc2	152..209	CDD:197706	17/62 (27%)
		I-set	230..319	CDD:254352	26/103 (25%)
		IGc2	243..309	CDD:197706	18/78 (23%)
		IG_like	330..424	CDD:214653	4/12 (33%)
		IGc2	339..412	CDD:197706	2/3 (67%)
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
IL1R1	NP_000868.1	Ig1_IL1R_like	24..113	CDD:319308	21/109 (19%)
		Ig2_IL1R_like	128..219	CDD:319309	25/92 (27%)
		IG	234..328	CDD:214652	21/103 (20%)
		TIR	384..540	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910