DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and bdl

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	176/829 - (21%)
Similarity:	284/829 - (34%)	Gaps:	248/829 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGKPLILTCR---P-TVPEPSLVADLQW-KDNR--------NNTILPKPNGR-----NQPPMYTE 92
            ||..::..|.   | ..|.|.||   .| |||:        ..:.....|||     |.|..
  Fly    47 VGSHVVFNCYIDFPFDAPIPYLV---HWTKDNKKIFTWYEQETSTSELFNGRLHLVENHPEF--- 105

  Fly    93 TLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTN----APENQYPTLGQ 153
               |.: ::.:|::.....|.|:|..|:.|.....:......::|:...:    .|.||....||
  Fly   106 ---GRA-SVNLTAIRESDQGWYHCQVSFPNRSPSVRNNGTAYHLAVQGGSLIRIPPVNQTIREGQ 166

  Fly   154 DYVVMCEVKADPNPTIDWLRNGDPIRTTNDK----YVVQTNGLLIRNVQESDEGIYTCRAAVIET 214
            .....|.:|...|....|.::|..::...|.    |:.....|.|.....||.|.|.|:....:
  Fly   167 TAFFHCVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSD- 230

  Fly   215 GELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGK-PVPEISWIRDATQLNVATADRF 278
            |||......:.:..:.::|..|..:....|:|...:|..|.. |:..:.|.:|....     |.:
  Fly   231 GELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLF-----DSY 290

  Fly   279 QV----NPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLV-RPQIYELYNVTG----- 333
            .|    ....|.:..:.|.::..|:|||...|..|.......::|:| ||.|   ::||.
  Fly   291 NVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPI---FSVTPKAIYI 352

  Fly   334 ARTKEIA-ITCRA---KGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRI 394
            .:..|.| :.|.|   .|...|:|.   ||.::    ||.....|..|          |.|.|.|
  Fly   353 QKLGEAAELPCEAIDRDGNNRPSII---WGRKD----GQPLPADRFSL----------SGGNLTI 400

  Fly   395 SNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNA 459
            :.....|.|:|:|.|.|:.|.      ||.|
  Fly   401 TGLVEGDRGIYECSATNEAAT------ITAE---------------------------------- 425

  Fly   460 TIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARV 524
                            ..|.|....||:
  Fly   426 ----------------AELMIENIAPRA------------------------------------- 437

  Fly   525 PDFVSEAKPSQLTA--TTMTFDIRGPSTELGLPILAYSVQYKEALNPDWST--AYNRSWSPDSPY 585
                    |..|||  |.....||.....| .|.|.|:|.|:....|:|.|  ..::.....:
  Fly   438 --------PYNLTANSTETCITIRWQPGYL-RPNLEYTVWYRLMEAPEWRTLRVLDKKVMEAT-- 491

  Fly   586 IVEGLRPQTEYSFRFAARNQVGLGNWGVN---QQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSP 647
             |:.|:|..||.|...::::.|.|.:...   |...:|.|:...:.:.|    |||..:  |.:|
  Fly   492 -VQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQL----QHDLGQ--VTAP 549

  Fly   648 --------------YSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMET 698
                          ....:.|.|..|....|.:..|.:::         |.|.|:.  .:...||
  Fly   550 AGGLGAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYAVRW---------WKEPEHF--LIGHAET 603

  Fly   699 --TSFEMTQLVGNTYYRIELKAHNAIG----YSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGI 757
              ..:::..|..:|.:::::.   |:|    .|.|:..::     |||  .::|:|  .|.|:|.
  Fly   604 FDNYYQLRHLKEDTLFKVQVL---AVGTETQQSVPSHELL-----IDV--PSQRKV--RALIIGS 656

  Fly   758 AIGGVLLLLFVVDLLCCITVHMGVMATMCRK--AK-RSPSEIDDEAKLG 803
            ::|       |:.|||.:...:.|..:..|.  || .|.||.:|.|:.|
  Fly   657 SVG-------VIFLLCALCAFLYVKRSCLRHLFAKDSSASEDEDTAESG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/104 (23%)
		IG_like	144..226	CDD:214653	22/85 (26%)
		IGc2	152..209	CDD:197706	16/60 (27%)
		I-set	230..319	CDD:254352	19/93 (20%)
		IGc2	243..309	CDD:197706	16/70 (23%)
		IG_like	330..424	CDD:214653	27/102 (26%)
		IGc2	339..412	CDD:197706	21/76 (28%)
		Ig	447..518	CDD:143165	4/70 (6%)
		fn3	534..611	CDD:278470	23/80 (29%)
		FN3	640..735	CDD:238020	18/114 (16%)
bdl	NP_608822.1	IG_like	42..128	CDD:214653	22/90 (24%)
		Ig	43..131	CDD:299845	23/93 (25%)
		I-set	153..242	CDD:254352	22/89 (25%)
		Ig	157..242	CDD:299845	22/85 (26%)
		Ig_2	252..337	CDD:290606	19/89 (21%)
		IG_like	260..327	CDD:214653	17/71 (24%)
		I-set	341..428	CDD:254352	30/162 (19%)
		IGc2	356..419	CDD:197706	23/79 (29%)
		FN3	435..524	CDD:238020	26/137 (19%)
		FN3	554..636	CDD:238020	15/95 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910