DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and itgb4

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	818	Identity:	152/818 - (18%)
Similarity:	264/818 - (32%)	Gaps:	256/818 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PTVPEPSLVADLQWKDNRNNTILPK------------PNGRNQPPMYTETLPGESLALMITSLSV 108
            |.:||.   .:|:..|..||.|:.|            .:|:||.....|         .:|..:.
Zfish  1181 PIIPEK---FNLELLDPSNNAIIGKRKTTEVIVTDGRGDGKNQDFQKME---------YVTQTAT 1233

  Fly   109 EMGGKYYCTASYANTEILEKGVTIKTYVAITW-----TNAPENQYPTLG--QDYVVMCEVKADPN 166
            ..||:.|   |.||.:.:..|   ...:.:.|     .|..:.:|...|  :|.....:||   .
Zfish  1234 SPGGRLY---SPANIKAVATG---PKNIRLNWKPSQNANGYKVKYWIYGDPEDKAKFMDVK---T 1289

  Fly   167 PTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPE 231
            |..: |.|.||. ...:..|...|.|        .:|.|:                        :
Zfish  1290 PQAE-LTNLDPY-CDYEMRVCGYNAL--------GDGNYS------------------------D 1320

  Fly   232 IISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQV---------------- 280
            ||...| ||.:.|:|...........|.::||...|....:.|.  ::|
Zfish  1321 IIQCQT-LEDIPGEPGRLAFNVISPTVTQVSWAEPAEANGIITG--YEVIYMPINEDKKPTGPPK 1382

  Fly   281 -----NPQTGLVTISSVSQDDYGTYTCLAKNRAG----------VVDQKTK-LNVLVRPQI---- 325
                 ||:..::.|.::.......|...|.|:.|          :..|.|: :::.:.|.|
Zfish  1383 KVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVGWGPYREATINLASQPTRPMSIPIIPDIPIVD 1447

  Fly   326 ---------YELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNF 381
                     |.:|:....|:...::        .|::|..   :.:::.||:        .|.||
Zfish  1448 AEAGEEYDSYLMYSNEVLRSPTSSL--------RPSVTDL---SDDQFVNGK--------WEQNF 1493

  Fly   382 DEERG---------ESTGTLRISNAERSDDGLYQCIARNKGADAY---KTGHITVEF-APDFSHM 433
            ....|         .|:.|....:..|::      :..|.....|   |.|..|..: ..|...:
Zfish  1494 LFPGGGGGSLSRNISSSSTTYSHSTPRTN------VTNNSSTTTYISGKGGSTTHRYDVRDGGLL 1552

  Fly   434 KELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQY 498
            ||  .|...::.:........|:.::.:..:.:|..:.:|        |....|.     .|...
Zfish  1553 KE--DVILRKRSENRHYTEGDGVRDSIVMGNLSGGLLDNL--------GVSSFSQ-----TTSTS 1602

  Fly   499 YSGYKCIATNIHGTAEH--------DMQLKEAR----VPDFVSEAKPSQLTATTMTFDIRGPSTE 551
            ||    :::.....:|.        |..|:|:|    ||...|....|.|..|.:....:.|..|
Zfish  1603 YS----LSSRARTQSEDINDALLNLDSVLQESRFTPGVPATPSRLVFSALGHTALKVSWQEPHCE 1663

  Fly   552 LGLPILAYSVQYK----------EALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQV 606
              ..:|.|.|.|:          |..||           ..:..:|:.|.|...|.|:..|:::.
Zfish  1664 --SDVLGYCVLYQLINGGDVKRIEVNNP-----------AQNSVLVQDLLPNQSYIFKVKAQSRE 1715

  Fly   607 GLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYS-----------------DHFEL 654
            |   ||..::......|..:...||         .||..||::                 |..:|
Zfish  1716 G---WGPEREGVITIESNVDPKSPL---------SPVPGSPFTLSTPSAPGPLIFTALRPDTLQL 1768

  Fly   655 RWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAH 719
            .|..|......|..|.:. |..:...|.....:.:.|.     .||..::.|..|..|:.:::|.
Zfish  1769 SWEKPRKPNGDILGYVVT-CEQLHGGGDLRSFQVNGNA-----ATSLTVSDLKENMPYKFKVQAQ 1827

  Fly   720 NAIGYSSPAS--IIMKTTRGIDVIQ-----VAERQVFS 750
            ...|:.....  |.:::..|..:.|     |.:|:||:
Zfish  1828 TTQGFGPEREGIITIESQDGGSMSQYSSQSVTKREVFN 1865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/88 (24%)
		IG_like	144..226	CDD:214653	15/83 (18%)
		IGc2	152..209	CDD:197706	14/58 (24%)
		I-set	230..319	CDD:254352	22/120 (18%)
		IGc2	243..309	CDD:197706	14/86 (16%)
		IG_like	330..424	CDD:214653	16/105 (15%)
		IGc2	339..412	CDD:197706	11/81 (14%)
		Ig	447..518	CDD:143165	10/78 (13%)
		fn3	534..611	CDD:278470	19/86 (22%)
		FN3	640..735	CDD:238020	21/113 (19%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020	22/123 (18%)
		FN3	1331..1420	CDD:238020	15/90 (17%)
		fn3	1640..1720	CDD:278470	22/95 (23%)
		fn3	1751..1835	CDD:278470	16/89 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900