DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and Il1rapl1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001153875.1	Gene:	Il1rapl1 / 331461	MGIID:	2687319	Length:	696	Species:	Mus musculus

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	138/384 - (35%)	Gaps:	113/384 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 VVQTNGL---LIRN------------VQESDEGI-YTCRAAVIETGEL---LERTIR-VEVFIQP 230
            ::|.:||   :|||            |.|:|.|: |..:....|..||   .|.:.| :|.|:
Mouse   109 LLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFL-- 171

  Fly   231 EIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQD 295
                |||.                   .|||.|.::..    ..|.|..:..:...:.|..|.:|
Mouse   172 ----LPTR-------------------EPEILWYKECR----TKAWRPSIVFKRDTLLIKEVKED 209

  Fly   296 DYGTYTCLAKNRAGVVDQKTKLNVLV----RPQ--IYELYNVTGARTKEIA----ITCRA----K 346
            |.|.|||..|....||.:.|:|.|..    :|.  :|.:.:....:..::.    :||||    .
Mouse   210 DIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYS 274

  Fly   347 GRPAPAITFRRWGTQEEY-----TNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQ 406
            |..:|.|   .|...|::     .|...:.|.||:.|...::|...|   |.:.:.|..|.|.|.
Mouse   275 GDVSPLI---YWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSIS---LIVDSVEEGDLGNYS 333

  Fly   407 CIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATI---------- 461
            |...|...    ..|.:|     ..|.:||  :::.|......:.|.:.|.:.||
Mouse   334 CYVENGNG----RRHASV-----LLHKREL--MYTVELAGGLGAILLLLICSVTIYKCYKIEIML 387

  Fly   462 --EWHWNGRKI----KDLYDTNLKIVGTGP-----------RSDLIVHPVTRQYYSGYK 503
              ..|:...::    || ||..|......|           |..|.:.|...:.:.|||
Mouse   388 FYRNHFGAEELDGDNKD-YDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYK 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	16/59 (27%)
		IGc2	152..209	CDD:197706	11/38 (29%)
		I-set	230..319	CDD:254352	22/88 (25%)
		IGc2	243..309	CDD:197706	15/65 (23%)
		IG_like	330..424	CDD:214653	24/106 (23%)
		IGc2	339..412	CDD:197706	22/85 (26%)
		Ig	447..518	CDD:143165	17/84 (20%)
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
Il1rapl1	NP_001153875.1	PHA02785	9..334	CDD:165149	64/259 (25%)
		Ig1_IL1RAPL-1_like	32..135	CDD:143304	6/25 (24%)
		Ig	148..234	CDD:299845	29/114 (25%)
		IGc2	260..341	CDD:197706	23/86 (27%)
		TIR	405..559	CDD:279864	10/41 (24%)
		Interaction with NCS1. /evidence=ECO:0000250	549..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000