DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Sdk1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	755	Identity:	195/755 - (25%)
Similarity:	281/755 - (37%)	Gaps:	173/755 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QRKPV--GKPLILTCRPTV--PEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALM 102
            |||.|  |...:|...|.|  |:|.:.    |....:..|   |:.|     ...||..:   |:
Mouse   180 QRKTVSQGHAALLNLLPIVSCPQPQVT----WFREGHKII---PSSR-----IAITLENQ---LV 229

  Fly   103 ITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAI-------TWTN---------APENQYPTL 151
            |.:.:....|.||..|      :.||....||...|       |.|:         ||.|:....
Mouse   230 ILATTASDAGAYYVQA------VNEKNGENKTSPFIHLSVARDTGTHEAMAPIIVVAPGNRSVVA 288

  Fly   152 GQDYVVM-CEVKADP--NPTIDWLRNGDPIRTTNDKYVVQTNG--LLIRNVQESDEGIYTCRAAV 211
            |.....: |...|.|  ..::.|.|||  :|.|:.   :.:.|  |.|.|...:|.|:|.|.|.:
Mouse   289 GSSETTLECIANARPVEELSVHWKRNG--VRLTSG---LHSYGRRLTITNPTSADTGMYVCEATL 348

  Fly   212 IETGELLERTIRVEVFIQ----PEIISLPTN--LEAVEGKPFAANCTARGKPVPEISWIRDATQL 270
              .|...| ..|...|:.    |...:.|.:  |..|| :.....|.|.|.|:|.:.|.:||..|
Mouse   349 --RGSTFE-PARARAFLSIIEPPYFTAEPESRILGEVE-ETMDIPCRAMGVPLPTLQWYKDAVPL 409

  Fly   271 NVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGAR 335
            :.....|::|.|..|| .|..:|.:|.|.:.|.|.|..|.|...|.|:|.         |:..|.
Mouse   410 SKLQNPRYKVLPSGGL-HIQKLSPEDSGIFQCFASNEGGEVQTHTYLDVT---------NIAPAF 464

  Fly   336 TKE-----------IAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGEST 389
            |:.           ..:.|...|.|.||||::|  ......:|.......::||          :
Mouse   465 TQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKR--GNHILASGSVRIPRFMLLE----------S 517

  Fly   390 GTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQR------KAN 448
            |.|||:.....|.|.|.|.|.|..|....:..:||.......|    ||    |.|      .|.
Mouse   518 GGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVH----PP----EDRVVIKGTTAT 574

  Fly   449 LSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIV-----HPVTRQYYSG----YKC 504
            |.|.|...|..::.:.|.    ||      .:|.|...|..||     ..|..|.:||    |.|
Mouse   575 LCCGATHDPRTSLRYVWK----KD------NVVITASSSSRIVVEKDGSLVISQTWSGDIGDYTC 629

  Fly   505 IATNIHGTAEHDMQLKEARVP----DFVSEAKPSQLTATTMT----FDIRGPSTELGLPILAYSV 561
            ...:..|:.....:|:...:|    :.::...|::..:.|::    ||  |.|     |:|.|.|
Mouse   630 EIISEGGSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFD--GNS-----PVLYYIV 687

  Fly   562 QYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPE 626
            |..|..:| |....:......:...|.||.|...|.||..|.||||.|.:..    .|.|...||
Mouse   688 QVSENNSP-WKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYST----ETSRLMLPE 747

  Fly   627 EP--KPLHNPVQHDKEEPVVVSPYSDHFELRWGVPAD---NG---EPIDRYQIKYCPGVKISGTW 683
            ||  .|..|.|...:....::        ::|..|.:   ||   ..|.||::...||
Mouse   748 EPPSAPPKNIVASGRTNQSIM--------VQWQPPPETEHNGVLRGYILRYRLAGLPG------- 797

  Fly   684 TELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIG 723
               |:....:...|.....:|.|:..|.|.|::.|:|..|
Mouse   798 ---EHQQRNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAG 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/94 (26%)
		IG_like	144..226	CDD:214653	24/86 (28%)
		IGc2	152..209	CDD:197706	18/61 (30%)
		I-set	230..319	CDD:254352	30/90 (33%)
		IGc2	243..309	CDD:197706	22/65 (34%)
		IG_like	330..424	CDD:214653	25/104 (24%)
		IGc2	339..412	CDD:197706	20/72 (28%)
		Ig	447..518	CDD:143165	20/79 (25%)
		fn3	534..611	CDD:278470	26/80 (33%)
		FN3	640..735	CDD:238020	19/90 (21%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606
		IG_like	100..169	CDD:214653
		IG_like	183..263	CDD:214653	24/100 (24%)
		Ig	197..247	CDD:299845	15/70 (21%)
		IG_like	281..357	CDD:214653	23/83 (28%)
		IGc2	294..347	CDD:197706	17/57 (30%)
		I-set	368..457	CDD:254352	30/90 (33%)
		Ig	388..454	CDD:143165	23/66 (35%)
		I-set	462..552	CDD:254352	24/101 (24%)
		Ig	476..552	CDD:299845	22/87 (25%)
		I-set	557..646	CDD:254352	26/106 (25%)
		Ig	562..646	CDD:299845	24/97 (25%)
		FN3	650..741	CDD:238020	28/102 (27%)
		fn3	753..839	CDD:278470	22/100 (22%)
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900