DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and dpr18

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	77/387 - (19%)
Similarity:	123/387 - (31%)	Gaps:	139/387 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGK-------YYCTASYANTEILEKG 129
            |..::.:|....|.:.||.|   || |:.....||.::..|.       ...|.::|:.::...
  Fly   119 NAPHSPIPTKMSRGKIPMET---PG-SMEFSSNSLPIKNVGTTDQLTTVTMPTTAFASLKVDRS- 178

  Fly   130 VTIKTYVAIT-----W--------TNAPENQY----------------PTLGQ----------DY 155
             |:|..:..|     |        |..|.:::                .|.|.          :.
  Fly   179 -TMKQPIDSTRTRNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINSATSGDNLVSAVHLFTEA 242

  Fly   156 VVMCEVKADPNPTIDWLR----------------NGDP-IRTTNDKYVVQTN-GLLIRNVQESDE 202
            |:.|.|....:.|:.|:|                :||| ||.   |:....| .|||...|..|.
  Fly   243 VLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRV---KFQYPNNWRLLINPTQTEDA 304

  Fly   203 GIYTCRAA-----VIETG-ELLERTIRV--------------------------EVFIQPE---- 231
            |:|.|:.:     |..|. .:||..:|:                          ..|.|.|
  Fly   305 GVYMCQVSTHPPRVFTTNLTVLEPPLRIIDEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQTI 369

  Fly   232 IISLPTNLEAVE-------------GKPFAANCTARGKPVPE-----ISWIRDATQLNVATADRF 278
            :.|..:..:||:             |..........|:.:.:     |:|.:|...|...|..|.
  Fly   370 LKSTDSANDAVQKLINETTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAKDEEPLQGMTNRRL 434

  Fly   279 QVNP--QTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKL----------NVLVRPQIYEL 328
            .|:.  .|..::|......|.|.|:|.......|:.|...|          |:..|.:||.|
  Fly   435 SVSDVWLTSRISIGDAKLSDSGNYSCSLGRLFTVIVQVQVLTGELPAAVQHNIGSRTEIYSL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	15/67 (22%)
		IG_like	144..226	CDD:214653	29/157 (18%)
		IGc2	152..209	CDD:197706	22/84 (26%)
		I-set	230..319	CDD:254352	22/122 (18%)
		IGc2	243..309	CDD:197706	15/85 (18%)
		IG_like	330..424	CDD:214653
		IGc2	339..412	CDD:197706
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	23/85 (27%)
		Ig	<258..326	CDD:299845	19/70 (27%)
		IGc2	<417..461	CDD:197706	12/43 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900