DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	1012	Identity:	221/1012 - (21%)
Similarity:	337/1012 - (33%)	Gaps:	313/1012 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGKPLILTCRPT-VPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTE-TLPGESLA-------- 100
            :|..:||:|..| .||    ..::|..|                  || .||||:::
  Rat   386 IGSTVILSCALTGSPE----FTIRWYRN------------------TELVLPGEAISIRGLSNET 428

  Fly   101 LMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTL-----------GQD 154
            |:|:|......|.|.|.|:       .|..|.:.:..|..    |:..|.:           |:.
  Rat   429 LLISSAQKSHSGAYQCFAT-------RKAQTAQDFAIIVL----EDGTPRIVSSFSEKVVNPGEQ 482

  Fly   155 YVVMCEVKADPNPTIDWLRNGDPI------RTTNDKYVVQTNGLLIRNV-----QESDEGIYTCR 208
            :.:||..|..|.||:.|..:.:|:      ||  ::|.: ::|..|.::     |..|.|:|.|.
  Rat   483 FSLMCAAKGAPPPTVTWALDDEPVVRDGSHRT--NQYTM-SDGTTISHMNVTGPQIRDGGVYRCT 544

  Fly   209 AAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDA------ 267
            |.  .:....|...|:.|...|.|.:: .|:.||.|:....||...|.|...|.|.:||
  Rat   545 AR--NSVGSAEYQARINVRGPPSIRAM-RNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDN 606

  Fly   268 --------------------------------TQLNVATA-----------DRFQVNPQT----- 284
                                            .||:::.:           ..|:..|.:
  Rat   607 HRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLL 671

  Fly   285 --------------------------------------GLVTISSVSQDDYGTYTCLAKNRAGVV 311
                                                  ..:.|||||....|.|||:|.|.|..|
  Rat   672 YIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATV 736

  Fly   312 DQKTKLNVLVRPQ-IYELYNVTGARTKEIAITCRAKGRPAPAITFRR---WGTQEEYTNGQQDDD 372
            .::.:|.|.|.|: :.:..|..|...|...:.|...|.|.|.:.::.   .|..::|       .
  Rat   737 SRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQY-------H 794

  Fly   373 P-----RIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARN-KGADAYKTGHITVEFA---- 427
            |     ||.:.||         .:|.|.:....|.|.|.|.|.| .|.|..|...:||:..
  Rat   795 PVPLTGRIQILPN---------SSLLIRHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMIT 850

  Fly   428 --PDFS-----HMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKD-----LYDTNLKI 480
              |:.:     |.||             |:|.|.|.....|.|. .|..:.|     .|....|.
  Rat   851 SHPNTTIAIKGHAKE-------------LNCTARGERPIIIRWE-KGDTVIDPDRVMRYAIATKD 901

  Fly   481 VGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FVSEAKPSQLTAT-T 540
            .|....|.|.:.|..|.....:.|.|.|.:|.....:||.....||    .:.|.|...:... |
  Rat   902 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWT 966

  Fly   541 MTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYI----VEGLRPQTEYSFRFA 601
            ..||  |.|.     |..:.::||   |...|..:.:|....||.|    :..|.|.:.||.|..
  Rat   967 QRFD--GNSI-----ITGFDIEYK---NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 1021

  Fly   602 ARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVP---ADNG 663
            :.|::|..........|| ..:||:.| |:...:|     ||.    |...::.|..|   ..||
  Rat  1022 SFNKIGRSEPSKELTIST-EEAAPDGP-PMDVTLQ-----PVT----SQSIQVTWKAPKKELQNG 1075

  Fly   664 EPIDRYQIKY---CPGVKISGTWTELENSCNTVEVMETTS----FEMTQLVGNTYYRIELKAHNA 721
             .|..|||.|   .||          .|...::..|:.|.    :.:..|.....|.:.::|.|.
  Rat  1076 -IIRGYQIGYRENSPG----------SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1129

  Fly   722 IGYSSPASIIMKTTRGIDV-----IQVAERQVFSSAAIVG------IAIGGVLLLLFVVDLLCCI 775
            .| :.|:|..:..|...||     ..|....:.|..|::.      ..:.|||....|:.....:
  Rat  1130 AG-TGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYV 1193

  Fly   776 TVHMGVMATMCRKAKR-----------------SPSEIDDEAKLGSLYGWRFPLPYCSGQLVKEP 823
            ....|.|..:....:|                 :.::..|..:...||           ...||.
  Rat  1194 DGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLY-----------IQTKED 1247

  Fly   824 PPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQ 860
            .|.|   |..:|...|..|:.:....|...|.|.|::
  Rat  1248 VPGP---PAGIKAVPSSASSVVVSWLPPTKPNGVIRK 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/96 (25%)
		IG_like	144..226	CDD:214653	24/103 (23%)
		IGc2	152..209	CDD:197706	19/67 (28%)
		I-set	230..319	CDD:254352	32/180 (18%)
		IGc2	243..309	CDD:197706	24/157 (15%)
		IG_like	330..424	CDD:214653	25/102 (25%)
		IGc2	339..412	CDD:197706	19/81 (23%)
		Ig	447..518	CDD:143165	19/75 (25%)
		fn3	534..611	CDD:278470	21/81 (26%)
		FN3	640..735	CDD:238020	24/104 (23%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845
		IG_like	195..276	CDD:214653
		I-set	291..369	CDD:254352
		IGc2	298..359	CDD:197706
		IGc2	386..447	CDD:197706	21/82 (26%)
		I-set	466..560	CDD:254352	23/98 (23%)
		Ig	466..556	CDD:299845	22/94 (23%)
		IGc2	577..635	CDD:197706	9/57 (16%)
		IG_like	665..744	CDD:214653	14/78 (18%)
		Ig	673..739	CDD:143165	13/65 (20%)
		I-set	748..843	CDD:254352	26/110 (24%)
		Ig7_DSCAM	765..843	CDD:143211	22/93 (24%)
		I-set	849..942	CDD:254352	25/106 (24%)
		Ig	861..949	CDD:299845	26/101 (26%)
		FN3	945..1039	CDD:238020	25/103 (24%)
		FN3	1046..1143	CDD:238020	27/118 (23%)
		fn3	1151..1237	CDD:278470	11/85 (13%)
		FN3	1249..1340	CDD:238020	10/36 (28%)
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810