DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	203/952 - (21%)
Similarity:	320/952 - (33%)	Gaps:	342/952 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PENQYPTLGQDYVVMCE----VKADPNP-TIDWLRNGDPI--------------------RTTND 183
            ||......|:..|:.|:    |...|.| .::|.:.|.||                    .:.:|
  Rat    30 PEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHD 94

  Fly   184 KYVVQTNGLLIRNVQESDEGIYTCRAAVIE-------TGELLERTIRVEVFIQPEIISLPTN-LE 240
            |     ..|.:..|:..|:|.|.|:..:::       .|..:..||..    .|.....|.. :|
  Rat    95 K-----ASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINA----PPTFTETPPQYIE 150

  Fly   241 AVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAK 305
            |.||......|||.|.|.|.::|:::.|.|  :.:.::||:  .|.:|::|||::|.|.|||.|.
  Rat   151 AKEGGSITMTCTAFGNPKPIVTWLKEGTLL--SASGKYQVS--DGSLTVTSVSREDRGAYTCRAY 211

  Fly   306 NRAGVVDQKTKLNV-----LVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYT 365
            :..|.....|.|.|     :|.|.    .|:|...:::..:||||:..|. .:|: .|..|:|..
  Rat   212 SIQGEAVHTTHLLVQGPPFIVSPP----ENITVNISQDALLTCRAEAYPG-NLTY-TWYWQDENV 270

  Fly   366 NGQQDDD--PRIILEPNFDEERGESTGTLRISNAERSDDGLYQCI-----ARNKGADAYKT---- 419
            ..|.|..  .||:::           |||.|...:..|.|.|.|:     .|:..|.||.|
  Rat   271 YFQNDLKLRVRILID-----------GTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYP 324

  Fly   420 -------------------------------------------------------GHITVE---- 425
                                                                   |.|.:|
  Rat   325 ARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATE 389

  Fly   426 -------------------FAPDFSHMKELPPVFS----WEQRKAN-----LSCLAMGIPNATIE 462
                               .||....:|: ||.|:    ||.|:..     :.|.|.|.|...|.
  Rat   390 EALGTYTCVPYNTLGTMGQSAPARLVLKD-PPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVIT 453

  Fly   463 WHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNI--------H----GTAEH 515
            |...|:..:..::..       |...|....::::.:..::|:|||:        |    ||:.|
  Rat   454 WRKVGKPSRSKHNAL-------PSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPH 511

  Fly   516 DMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQY-----KEALNP-DW--- 571
            ........|          .:|...::::   |..:.|.. ..:||.|     :....| ||
  Rat   512 APGSVRVHV----------SMTTANVSWE---PGYDGGYE-QTFSVWYGPLMKRAQFGPHDWLSL 562

  Fly   572 STAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWG----VNQ---QQSTPRRSAPEEPK 629
            |.....||     .:|:.|.|:|.|.|...|:|::|...:.    ||.   ..:||      ||.
  Rat   563 SVPLGPSW-----LLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTP------EPL 616

  Fly   630 PLHNP----VQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSC 690
            .|..|    ..:..::.|::|         |..||::..|||||.:::    ::...|..|:::.
  Rat   617 VLVTPPRCLTANRTQQGVLLS---------WLPPANHSFPIDRYIMEF----RVGERWEMLDDAI 668

  Fly   691 NTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIV 755
            ...:    ..|....|..:|:|...:.|......|.|::|          ..|:...:|....:.
  Rat   669 PGTD----GEFFAKDLSQDTWYEFRVLAVMQDLISEPSNI----------AGVSSTDIFPQPDLT 719

  Fly   756 GIAIGGVLLLLFVVDLLCCITVHMGVMATMC---------------------RKAKRS---PSEI 796
            ...:...:|              .|::||:|                     ||.||.   |..|
  Rat   720 DDGLARPVL--------------AGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSI 770

  Fly   797 DDEAKLGSLYGWRFPLPYCSGQLVKEPPPSPLPLPPPVKLG---GSP----MSTPLDEKE----- 849
            ....|  ||..     |..||   |..|.|...|..|.:..   |.|    |.:|..|||
  Rat   771 THCRK--SLES-----PLSSG---KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYK 825

  Fly   850 --------------------PLRTPTGSIKQNSTIEFDGRFV 871
                                ...||...|.:..    |||||
  Rat   826 KTKRAISSRKYSVAKAEAEAEATTPIELISRGP----DGRFV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	23/113 (20%)
		IGc2	152..209	CDD:197706	18/81 (22%)
		I-set	230..319	CDD:254352	31/89 (35%)
		IGc2	243..309	CDD:197706	24/65 (37%)
		IG_like	330..424	CDD:214653	30/159 (19%)
		IGc2	339..412	CDD:197706	22/79 (28%)
		Ig	447..518	CDD:143165	17/87 (20%)
		fn3	534..611	CDD:278470	21/85 (25%)
		FN3	640..735	CDD:238020	20/94 (21%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	17/78 (22%)
		I-set	139..225	CDD:369462	31/89 (35%)
		Ig	229..321	CDD:386229	29/108 (27%)
		Ig	<353..414	CDD:386229	5/60 (8%)
		Ig	438..502	CDD:319273	13/70 (19%)
		FN3	510..605	CDD:238020	24/113 (21%)
		FN3	621..703	CDD:238020	20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821		20/68 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900