DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and rst

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	168/817 - (20%)
Similarity:	267/817 - (32%)	Gaps:	279/817 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKA 163
            |.|:.|.:.:.....|   .||.|..               :...|::|...:|....:.|.| .
  Fly     7 LLLLATIVGMVRSSPY---TSYQNQR---------------FAMEPQDQTAVVGARVTLPCRV-I 52

  Fly   164 DPNPTIDWLRNGDPIRTTND-----KYVVQTN------GLLIRNVQESDEGIYTCRAAVIETGEL 217
            :...|:.|.::...:.|:.|     :|.:..:      .|.|..|...|:..|.|:.:....|:.
  Fly    53 NKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQP 117

  Fly   218 LERT--IRVEVFIQPEI--ISLPTNLEAVEGKPFAANC-TARGKPVPEISWIRDATQLNVATADR 277
            ..|:  ..:.|.:.||.  |:....:.|.|.:.....| :..|||..||:||....  ||.| |.
  Fly   118 AIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLG--NVLT-DN 179

  Fly   278 FQVN----PQTGLVTISSV-----SQDDYGT-YTCLAKNRAGVVDQKTKLNVLVR--PQIY---- 326
            .:..    |.....|..||     .::.:.| ::|.|:|.|....:..|:.|.|:  |::.
  Fly   180 IEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVM 244

  Fly   327 -----------------ELYNVTGARTKE---IAITCRAKGRPAPAITFRRWGTQEEYTNGQQ-- 369
                             .::..||:|..|   :.:.|||...|:. :.:|.:...|....||:
  Fly   245 GSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSD-VRYRWFINDEPIIGGQKTE 308

  Fly   370 -------------------------------------------------------------DDDP 373
                                                                         |.:|
  Fly   309 MVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNP 373

  Fly   374 R---IILEPNFDEERGESTG-TLRISNAERSDDGLYQCIARNKG-----ADAYKTGHITVEFAPD 429
            :   :.::...|...|.||. |..:||   ...|.|.|.|...|     ||||
  Fly   374 QPEIVWIQHPSDRVVGTSTNLTFSVSN---ETAGRYYCKANVPGYAEISADAY------------ 423

  Fly   430 FSHMKELPPVFSWEQR--------KANLSCLAMGIPNAT-IEWHWNGRKIKDL----YDTNLKIV 481
             .::|..|.:.|  ||        .|.:.|.|..:|.|. :.|.:||::|...    |...:..|
  Fly   424 -VYLKGSPAIGS--QRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAV 485

  Fly   482 GTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIR 546
            ..|.:|.||:......:|..|.|...|.:|....::||          :||.|.....|:...|.
  Fly   486 PGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQL----------QAKKSVSLLMTIVGGIS 540

  Fly   547 GPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNW 611
            ..:..|.|.||.  |.|.:        ...|:..|.:..|.|               :|: ..|.
  Fly   541 VVAFLLVLTILV--VVYIK--------CKKRTKLPPADVISE---------------HQI-TKNG 579

  Fly   612 GVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNG-EPIDRYQIKYCP 675
            ||         |...||        .|:     .|.|||   |:  |....| .|...|...|.|
  Fly   580 GV---------SCKLEP--------GDR-----TSNYSD---LK--VDISGGYVPYGDYSTHYSP 617

  Fly   676 --------GVKISGTWTELENS-CNTVEVM------------ETTSFEMTQLVGNTYYRIELKAH 719
                    ..|.:|:.|.::|: .|.:::.            :||:..||.|.
  Fly   618 PPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLT------------ 670

  Fly   720 NAIGYSSPASII----MKTTRGIDVIQVAERQVFSSA 752
            |:.|.|...|||    ::...|:..:|.....|.||:
  Fly   671 NSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSS 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	7/33 (21%)
		IG_like	144..226	CDD:214653	18/94 (19%)
		IGc2	152..209	CDD:197706	14/67 (21%)
		I-set	230..319	CDD:254352	27/101 (27%)
		IGc2	243..309	CDD:197706	21/76 (28%)
		IG_like	330..424	CDD:214653	30/168 (18%)
		IGc2	339..412	CDD:197706	21/139 (15%)
		Ig	447..518	CDD:143165	20/75 (27%)
		fn3	534..611	CDD:278470	14/76 (18%)
		FN3	640..735	CDD:238020	27/120 (23%)
rst	NP_001284835.1	IG_like	34..130	CDD:214653	19/96 (20%)
		Ig	42..114	CDD:299845	14/72 (19%)
		C2-set_2	135..225	CDD:285423	24/92 (26%)
		Ig_3	265..329	CDD:290638	12/64 (19%)
		I-set	346..420	CDD:254352	14/76 (18%)
		Ig	360..425	CDD:299845	18/80 (23%)
		Ig5_KIRREL3-like	428..524	CDD:143235	26/107 (24%)
		IG_like	435..524	CDD:214653	24/98 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810